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The mechanism of cell death induction in human malignant melanoma in vitro
Rudolf, Kamil ; Červinka, Miroslav (advisor) ; Mlejnek, Petr (referee) ; Janisch, Roman (referee)
Melanoma is a complex malignant disease characterized by increasing incidence and mortality. Melanoma biology is complicated and comprises many aberrant genes and signaling pathways. Treatment of melanoma relies on surgery, the role of radiation therapy and chemotherapy are limited. In advanced disseminating and metastasizing melanoma chemotherapy largely fails and that is why new approaches are being sought including identification of deregulated molecules or processes which could be used as targets. Some of these targets center on frequently aberrant cell death regulating mechanisms. Some traditional cytostatic drugs such as inhibitors of topoisomerases although useful in other types tumors so far proved useless in treatment of melanoma. Nevertheless, expression of topoisomerases in melanoma is often high, thereby enabling at least theoretically their use as targets for chemotherapeutical intervention. Aim of this study was to assess the cytoxicity and proapoptotic effect of campthotecin (topoisomerase I inhibitor), etoposide (topoisomerase IIα inhibitor) and their combination in selected human melanoma cell lines. We found that campthotecin may induce apoptosis by a combination of mechanisms including p53 as well as p73 and kaspase-2. Etoposide-induced cell death in Bowes melanoma cells included...
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History and present of the cross-country race Krkonošská 70
Kirschová, Jana ; Matošková, Petra (advisor) ; Gnad, Tomáš (referee)
Name: History and present of the cross-country race Krkonošská 70 Aim: Deeper insight into the problems Giant ski run seventy, with its detailed mapping of historical development, including a description of the organization and the organization of this endurance race. Method: The method is based on the search, study and processing search of available literature, data collection and materials; then the analysis of these documents. The actual description of the organization are based on structured interview with the organizers. results: Served comprehensive statement about the historical development Krkonošské 70 illuminate the organizing plant and provide guidance on organizing ski runs. Keywords: Krkonošská 70, remote ski run, a mass race in cross-country skiing race patrols, Worldloppet, Euroloppet Powered by TCPDF (www.tcpdf.org)
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C-reactive protein in microbial environment of burned persons
Šetelíková, Lenka ; Bartůňková, Staša (advisor) ; Vránová, Jana (referee)
Subject C - reactive protein in microbial wor/d ofburnt Thesis Aim: Familiarization with burn injury - highlighting of importance of complex care of burnt patients, familiarization with specific characters of infection of the burn trauma Monitoring of most frequent bacteria of the burnt patients, monitoring of CRP values Detection of the CRP IeveI differences of sportsmen and of humans who do not do sport for selected bacteria Method: Thesis is divided in three parts. Burn trauma, possible infection complications and most frequent types of bacteria are described in the clinical part. Thesis aims and goals, problematic issues, characteristics of patient group, methodology and data processing are determined in the research part. Final examination outputs are projected in the result part. Results: We have processed huge amount of available information on burn trauma incl. psychological care and physical therapy. Thus we have highlighted the burn injury and importance of complex and continual care of burnt people. We have pointed out the specific characters of infection. We have determined the most frequent bacteria by monitoring of bacteriological examinations and we have detected values of CRP level in serum by monitoring of biochemical examinations. We have acquired survey of the relation of...
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Effects of The Comprehensive Care on Communication Abilities of A Child Cerebral Palsy
Jonášová, Eva ; Soudná, Kateřina (advisor) ; Šarounová, Jana (referee)
Název práce: Vliv ucelené péče na rozvoj komunikace u dítěte s DMO Název práce v anglickém jazyce: Effects of The Comprehensive Care on Communication Abilities ofA Child after Cerebral Palsy Cíle práce: Shrnut dostupné informace o ucelené rehabilitaci dětí s dětskou mozkovou obrnou. Popsat průběh rozvoje komunikace u dívky s dětskou mozkovou obrnou v kontextu s komplexní rehabilitací, konkrétní využití náhradních forem dorozumívání a pomůcek k tomu potřebných, jejich pomoc k dosažení a rozvinutí náhradní komunikace. Metody: rozhovor s rodiči (kombinace částečně strukturovaného rozhovoru s otevřenými otázkami a rozhovor pomocí návodu), pozorování (nepřímé pozorování), analýza dokumentů (lékařská dokumentace, pedagogická dokumentace, internetové stránky, tisk) kazuistika Klíčová slova: ucelená rehabilitace, dětská mozková obrna, vývoj řeči, verbální komunikace, neverbální komunikace, alternativní komunikace I
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Comparison of driving comfort between Cars of Professional Racing Drivers and Normal Drivers
Palová, Miroslava ; Jelen, Karel (advisor) ; Lopot, František (referee)
Work title: The discomfort experienced by racing drivers when driving in comparison to the discomfort experienced by ordinary drivers ofpassenger cars. Work objectives: The objective of this theses is actual detection of discomfort and comparison of the reaction time of professional racing drivers with drivers of passenger vehicles when driving and mutual comparison of their results. By using subjective and objective methods we will monitor and record how discomfort is manifested by individuals, how it influences their complexly dealing with movement manoeuvres and how it changes in time during the course of driving.. Method: Three professional racing drivers and a sample of randomly chosen subjects ranging in age from 20-28 years were tested in a reaction and decision making test, requiring reactions to visual impulses from the upper and lower limbs. Additional tests evaluated the discomfort ofthe test subjects and the current mental state ofthe individua!. Results: With regard to the current mental state of the individua! the mood profile of the professional drivers was 5 points more stable, which shows that the racing drivers have a greater mental endurance in comparison to ordinary passenger vehicle drivers. The discomfort intensity was 5.34 points lower for professional drivers compared to...
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Intensive Care of the Paediatric Invasive Meningococal Infection
Šutoriková, Veronika ; Vobruba, Václav (advisor) ; Bartůněk, Petr (referee)
The thesis deals with the issue of the pediatrie invasive meningococcal infection. Theoretical part is focused on the deseription of meningococcal infection, its incidence, epidemiology, clinical picture, complication and consequences. diagnosis, therapeutic and preventions procedures. Also there is an emphasis on early detection and prompt treatment of sepsis shock. The nursing section of the thesis includes comprehensive care of a seven-month-oldinfant. This is a deseriptive report which deseribes the dynamic course of the disease, aggressive treatment including antibiotics, steroids, respiratory support, circulation support, renal replacement therapy and overall therapy of disseminative intravascular coagulation syndrome. Through that care the child survived without any mutilation. The case report focused on the needs of the child and its mother in nursing care. It elaborates the main nursing diagnoses, their targets, plans and realizations.
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The use of altitude training in Olympic cycle 2004-2008 (in the example of rowing)
Knapková, Miroslava ; Panuška, Přemysl (referee) ; Suchý, Jiří (advisor)
Title: The use of altitude training in Olympic cycle 2004-2008 (in the example of rowing) Aim: The operational objective of this work is to provide a summary of selected published information on the issue of altitude training, and its use in rowing. The main aim of this work will be the practical verification of the theory of recovery training at higher altitude, focusing on the example of rowing through the evaluation of biochemical analysis. Another aim will be to determine whether training at higher altitude might have positively affected the performance of rowers in the Olympic cycle 2004-2008. Methodology of work: Based on the knowledge gained from a literature review on the matter we are planning to organize training camps at altitude in the four-year Olympic cycle. According to those tasks and objectives each year in the annual cycle, we chose the suitability of training camp at altitude. During the training camp at altitude as we are use biochemical analysis to test the use of training at altitude in practice. The results: The results of monitoring the internal environment and the hematology using biochemici analysis showed that altitude is limiting for training. Nevertheless, altitude training can be used as a means of improving athletic performance at sea level, because adaptive changes...
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Maroslav Tyrš for the School of the Third Millenium
Nosek, Tomáš ; Parry Martínková, Irena (advisor) ; Bednář, Miloš (referee)
Název: Miroslav Tyrš pro školu třetího tisíciletí Miroslav Tyrš for the School of the Third Millenium Cíle práce: Cílem této práce je napsat životopis a přehled díla Miroslava Tyrše, který by měl sloužit širší pedagogické veřejnosti jako výchozí text k poznání Tyrše a Tyršovy doby, kdy došlo k dovršení národního obrození. Text by měl podat komplexní informaci o Tyršově mnohostranném působení tak, aby pedagog věděl, jaké zdroje má vyhledat při zaujetí konkrétním tématem. Metody: Literárně - historická analýza, interpretace pramenů. Klíčová slova: Miroslav Tyrš, Sokol, národní obrození, tělocvik, výchova, národ, kalokagathia
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Specific Features of Secondary Care for Persons after Stroke
Nesvadba, Aleš ; Kohlíková, Eva (advisor) ; Cabalová, Alena (referee)
Subject Specific of secondary care with people after stroke Objective: attention to the occurrence of stroke and its aftermath emphasize the importance of a comprehensive follow-up care for patients after stroke current state of development of aftercare develop existing information and submit information about aftercare for people after stroke Method: The work is divided into several parts. In the clinical part is described in detail the etiology, course and therapy of stroke. The next section analyzes the current state of the subsequent care of affected patients, the origin and content of some civil associations dealing with this issue. Then there is a program developed provided reconditioning stays clients after a stroke. Results: Work objectives have been met. Authors have an adequate amount of information available on follow-up care for people after stroke as well as disease itself. We pointed to the disease and importance of a comprehensive after-care of persons affected by this disease. In the subsequent care, we introduce some civil associations dealing with these issues, the focusing on the association with which actively for many years worked. We also experience prepared held reconditioning stays and created a master plan reconditioning stays held in 2006. Over the years, our primary...
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