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A comparison of central and peripheral effect of galantamine.
Galusová, Petra ; Vopršalová, Marie (referee) ; Herink, Josef (advisor)
Galantamine is a reversible inhibitor of acety1cholinesterase (AchE). It is recommended for the treatment of rnild to moderate Alzheimer's dementia, vascular dementia and dementia with Lewy bodies. Galantamine is characterized as cognitive enhancer with dual mechanism ofaction (it has also shown activity in modulating the nicotinic cholinergic receptor). The aim of this work is to determine the effective inhibitory dose of galantamine on the selected route of administration and comparing its central and peripheral effects of galantamine. Determination to proceed on the basis of the fmdings of AchE activity in the central nervous system (in the frontal cortex, hippocampus, septum, basal ganglia and pituitary gland) and on the contrary peripheral nervous system activity of butyry1cholinesterase has been detected (specifically in the liver and plasma). The results obtained by the Ellman's method showed that galantamine is generally a weak inhibitor and statistically significant effect is found only at the highest dose used. At the highest dose used can be expected adverse effects of peripheral type.
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Study of the relations between the structure and function of C - terminal vanilloid receptor TRPV1
Gryčová, Lenka ; Obšil, Tomáš (advisor) ; Heřman, Petr (referee) ; Urbánková, Eva (referee) ; Krůšek, Jan (referee)
Transient receptor potential channel vanilloid receptor subunit 1 (TRPV1) is a thermosensitive cation channel activated by noxious heat as well as a wide range of chemical stimuli. Although ATP by itself does not directly activate TRPV1, it was shown that intracellular ATP increases its activity by directly interacting with the Walker A motif residing on the C-terminus of TRPV1. In order to identify the amino acid residues that are essential for the binding of ATP to the TRPV1 channel, we performed the following point mutations of the Walker A motif: P732A, D733A, G734A, K735A, D736A, and D737A. Employing bulk fluorescence measurements, namely a TNP-ATP competition assay and FITC labeling and quenching experiments, we identified the key role of the K735 residue in the binding of the nucleotide. Experimental data was interpreted according to our molecular modelling simulations. Calmodulin (CaM) is known to play an important role in the regulation of TRP channels activity. Although it has been reported that CaM binds to the Cterminus of TRPV1 (TRPV1-CT), no classic CaM-binding motif was found in this region. In this work, we explored this unusual TRPV1 CaM-binding motif in detail and found that five residues from a putative CaM-binding motif are important for TRPV1-CT's binding to CaM, with arginine R785...
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Horse in the frame of human culture
Reinbergerová, Anna ; Opletalová, Lenka (referee) ; Czumalo, Vladimír (advisor)
The dissertation "Horse in the history of human culture" presents a summary of a history of horse in the human culture. Horses have played a significant role in homo sapiensis evolution ever since it came to Eurasia. From beeing hunted for food, horses soon turned in the process of domestication into working, riding and driving animals of significant importance. In different cultures and epochs, different types of horses of different purposes have been emerging. But since its domestication, horses have allways been tellig a story of culture in its time and space. This is why this topic is a part of the wide array of interest of the therory of culture. In this dissertation, I chose to catch a relation of horses and culture in the historic circumstancies. I hoped to connect my experience with horses with scientific literature on this topic, historical facts and presently existing historical artefacts related to horses. In most of scientific and historical literature, many notes on horses may be find, but mostly they are interpreting the facts wrogly, and sometimes they are even wery far from the truth. the historicians usualy lack the needed knowledge of hipology, etology and zoology. It is common that mainly the horse illustrations are incorrectly described and understood. In the hipological literature, on...
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The causes of poor learning results in the subject 6MI211 - Data Analysis
Ryšavá, Iveta ; Komárková, Lenka (advisor) ; Voráček, Jan (referee)
The aim of this bachelor thesis is to statistically process data related to the failure of full time students in the subject Data Analysis and to appropriately interpret the acquired results. Resources to our work are the academic results based on Data Analysis and Math for economists from the winter semester of the academic year 2006/2007 and 2007/2008 and, in particular, a questionnaire formulated by ourselves. The nature of the data collected leads to the analysis of qualitative variables. First single data are described using a table of relative and absolute frequencies for each variable. In addition, we have worked with selected pairs of variables, namely the two-data which are processed in the form of contingency tables and these tables are then further analyzed. There are, inter alia, used tests of independence and homogeneity. For better understanding we have used the tables and the related tests are completed by graphs. From our bachelor thesis, we expect that we find the views of students on this subject and find out, why this subject causes so many problems for most of them.
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Kinematics analysis of basketball player's movement and shooting
Pantůček, Stanislav ; Zahálka, František (advisor) ; Kaprálek, Tomáš (referee)
Name: Kinematics analysis o basketball player's movement and jump shot Main task: Analysis technical method facture movement in jump shot after the one and more dnoble. Comparison and subsequently resulting evaluation kinetic cycle intraindividualni steadiness single shooting attempt laid player and appreciation inter-particular steadiness fulfilment kinetic cycle tracked insider. Method: Space kinematic analysis fulfilment kinetic cycle in jump shot and areal kinematic analysis ball flight trajectory. Results: Adventitious record reflect spatio-temporal solving (in the technical fulfilment) single shooting attempt investigation player, below suggestive of kritical points and singles phases at classification laid shooting attempt in analyze group. Endeavour be formed didactic interpretation in traning. Keyswords: basketbal!, jump shot, space and areal kinematics analysis
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Bilingual English-Czech Dictionary of Swimming Technigue Terminology and Qualitive Analysis of its Terms
Pomališová, Lenka ; Hrobařová, Barbora (referee) ; Pípalová, Renata (advisor)
The aim of the present work was compiling a bilingual English-Czech glossary of swimming technique terminology by means of excerpting literature. From the excerpted terminology the author created a bilingual glossary alphabetically ordered and a glossary ordered according to the terms' semantic fields. The theoretical part of the work presents qualitative analysis of the swimming terms. The dictionary is designed for practical use at the Department of Swimming at the Faculty of Physical Education and Sport (FTVS) in Prague, for the lecturers, coaches, students as well as translators and interpreters dealing with the swimming terminology. Powered by TCPDF (www.tcpdf.org)
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Cyber security from the perspective of business entities
Kameníček, Lukáš ; Buchalcevová, Alena (advisor) ; Čermák, Igor (referee)
This thesis deals with the issue of cyber security in enterprises. The main objective of this thesis is to compile a comprehensive overview of the issue of cyber security related to the Czech business entities. It is written in the context in Czech language and in less technical form. This thesis first identifies the current cyber threats, supported by examples of actual incidents. On the basis of the threats thesis defines the categories of business entities that are vulnerable to the threats, and with regard to the Czech legal system analyzes cybersecurity responsibilities. Above the legal obligations there are recommended measures and types of security tests that can check the level of cybersecurity. The output is also a methodological tool for better understanding of cyber security in companies which summarize acquired information and context in comprehensive tables. The expected contribution of this thesis is that summarized findings will serve to increase the level of IT security for Czech businesses.
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Analysing options to increase the attractiveness of graduates of the University of Economic, Prague in the labour market
Pospěchová, Michaela ; Jarošová, Eva (advisor) ; Motlová, Veronika (referee)
The thesis focuses on analysing the possibility of increasing the attractiveness of graduates of the University of Economics Prague (VŠE) in the labour market. It maps the opportunities for enhancing the knowledge and skills beyond the scope of the regular instruction. The theoretical part among others includes an overview of the historical development of the number of university graduates and their employability in different fields. Furthermore, it focuses on the interpretation of selected theories of career management, the topic of career development and the career management skills, the so called new careers and new psychological contracts (all in relation to university graduates). The empirical part includes the analysis of students potential activities that may play a role in their entry in the labour market. The empirical investigation was carried out focused on the expectations of employers in relation to graduates and to what extent do employers take into account graduates previous activities for acquiring knowledge and skills beyond the scope of their studies. The results of the work are the practical recommendations for students / alumni of VŠE justified on the basis of the analysis.
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Statistical analysis of unemployment in selected region
Blažková, Adriana ; Hošková, Pavla (advisor) ; Petr, Petr (referee)
This thesis deals with the analysis of unemployment in the region Usti. Review of literature contains theoretical issues relating to the labor market and unemployment. Practical part of work is focused on the analysis and interpretation of the evolution of unemployment by using the indicator of unemployed people and the number of unemployed in the years 2005 - 2015 and prediction of future development of these indicators. Statistical methods are used for the analysis and prediction. Practical part of work also describe selected structural characteristics of the unemployed to find an problematic group of registered job seekers. In conclusion, summarizing the results and show proposals for dealing with unemployment in the Usti region.
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Integration of individuals into social groups in different life situations in the selected region
Šámalová, Zuzana ; Varvažovská, Pavla (advisor) ; Tomáš, Tomáš (referee)
This thesis deals with the issue of integration of individuals into a social group in different life situations in the Pilsen region. Primarily it focuses to forms of assistance which are provided by the region to the children leaving the Halfway house or the children home established by the Pilsen region. The thesis analyzes public opinions on the issue of integration of the children from the children home into society and finds out their own positions of adolescents, executives and employees of social facilities. It also analyzes the issue within the development of the Pilsen region. The objective is to propose ways to integrate individuals without a family into the social groups in different life situations in the Pilsen region. The theoretical part deals with the period of socialization of a child and the absence of a family as the main factor of socialization. It describes a system of constitutional education in the Czech Republic, the lives of children in the Halfway house and programs on the issues of leaving the children home. The field research is performed with a purpose of achieving objectives, sub-objectives work and then interpret their results. The results obtained and subsequent recommendation are summarized for the establishing institution children home (thus Pilsen Region) in the conclusion of this work. To achieve the main objective is proposed the way to integrate individuals into the social groups in the form of new work position social guide.
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