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Cleaning processes validation 1.
Hynková, Aneta ; Berka, Pavel (advisor) ; Doležal, Pavel (referee)
The theoretical part deals with the problems of cleaning validation as one of the basic principles of quality assurance, which should secure the production of safe, effective and quality medicines. Validation of cleaning processes is required by good manufacturing practice, particularly to prevent contamination of raw materials, intermediate products, products and other materials. This work deals with the legislative control of validation, its organization and formalities. It also deals with the issue cleanliness in manufacturing facilities and its evaluation. The experimental part was carried out in a pharmaceutical company Teva Czech Industries s.r.o in Opava. Analytical method for flutamide was developed and validated. The analytical method will be used to cleaning validation of the device in which it will be produced in the future. Validation of the analytical method included verification of validation characteristics such as accuracy, precision, specificity, linearity, detection and the limit of quantification and stability. Keywords: pharmaceutical manufacturing, validation, cleaning
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Insulating Properties of Flip Chip Structures
Dóczy, Robert ; Šandera, Josef (referee) ; Pulec, Jiří (advisor)
This work deals with the insulation properties of microelectronic structures. Specifically, insulation resistance of the gap that separates the conductive parts of the system. There are also described the influences, which have the effect on insulation resistance and the methods by which the insulation resistance is measured. There are also slightly described the issues of designing microelectronic packages and ways in which the microelectronic chip can be connected to the circuit. In the experimental part, the thesis deals with specific design of microelectronic structure such as flip-chip. Conductive pattern of this structure was made to allow the measurement of insulation resistance which depends on the application materials which were used in structure assembly. For this purpose, the structures also undergo a series of cleaning, whose influence is also discussed.
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Nanoelectrodes for biophysical measurements
Márik, Marian ; Hrdý, Radim (referee) ; Hubálek, Jaromír (advisor)
The aim of the project is formation of nanoelectrodes on the silicon wafer surface by thin-film techniques combined with lithography and nanotechniques developed in LabSensNano. Project is engaged in lithography and in preparation of silicon wafers. Furthermore is proposed a brief proposal of electrodes, proposal of realization and current state of the experiment.
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Monitoring of efficiency cleaning medium for printed circuit board
Jelínek, Tomáš ; Řezníček, Michal (referee) ; Buršík, Martin (advisor)
In this bachelor thesis various methods of cleaning and various types of cleaning agents commonly used in electrical engineering are described. In the experimental part cyclic voltammetry is used to measure the current–voltage characteristic of cleaning agent VIGON A 200. The new and the used cleaning agents are compared. Influence of measuring sensors is monitored. At the end of the bachelor thesis obtained data are evaluated and further processing steps for analysis are proposed.
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Cleaning of ventilation systems and potential energy savings
Lapáček, Milan ; Rubina, Aleš (referee) ; Máša, Vítězslav (advisor)
The main aim of this thesis is to explore fouling of air ducts and its influence on energy consumption of HVAC systems. The first part focuses on typical parts that create the IAQ in buildings and on evaluating energy consumption of air transportation. The following section deals with the theories of fluid flow, flow regimes and pressure losses that are created as a side effect. The thesis outlines possible methods of assessing the impact of pollution with an emphasis on pressure losses and their influence on the fan power consumption. The actual experimental measurement, conducted in a selected industrial plant, is focused on an influence of cleanness of textile diffuser on HVAC device power consumption. For the further research of this process, measuring equipment with suitable measurement method is designed and constructed.
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Optimizing the Manufacturing Process in a Company
Vrána, Jakub ; Novák, Viktor (referee) ; Videcká, Zdeňka (advisor)
This thesis deals with the management of the production process, focusing on unproductive activities. It comprises analysis of the current situation in the company Teva Czech Industries s.r.o. (the TCI) and suggestions for improvement measures. The first chapter presents theoretical basis for processing work. PMT methods, namely MTM and MOST, lean production with a focus on 5S, TPM and Kaizen are described. The second chapter is focused on the company TCI, core business, organization structure and analyzes the current status. It’s focused primarily on the process of critical non-manufacturing operations and the changeover cleaning process. The third chapter, following the analytical part consists of the proposed recommendations. The fourth chapter deals with the final evaluation.
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Analyze of Packaging Impact on Insulating properties
Pulec, Jiří ; Hejátková, Edita (referee) ; Szendiuch, Ivan (advisor)
Modern analog systems processing signals with very small amplitude are prone to distortion, which is caused by leakage between signal traces. Causation of this is contamination of insulating gap, which insulates these traces. Goal of this thesis is to design and manufacturing of test structure, which allows classification of influence of contamination on substrate on leakage, and another goal is classification of technologiacal processes in light of contamination of substrate with electroactive inpurities. Based on results of this experiments are defined rules leading to optimizing of properties of manufactured structures. Attention is applied to ceramic substrates with conductive traces which are created with thick film technology.
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Lifetime measurement of current carriers in silicon solar cells structures
Macháček, Martin ; Hégr, Ondřej (referee) ; Boušek, Jaroslav (advisor)
This thesis deals with a lifetime measurement of current carriers in silicon solar cell structures. In the first chapter there is a description of several recombination models and their participation at a final effective lifetime value. By using these recombination models in a computer simulation it is possible to receive approximate evaluation of some important silicon solar cell structure parameters. The PC1D simulation program was used for this thesis. For the lifetime measurement of real test-wafers two methods were used: QSSPC (quasi-steady-state photoconductance) and MW-PCD (microwave photoconductance decay). There is a detail description of these methods, used measurements machines and differences between both of them in the chapter four. The main objective of the thesis is mentioned in the last chapter, which is mainly focused on a chemical passivation of silicon wafers and deals with a problem of post-passivation wafer cleaning. There are three passivation techniques mentioned: the iodine in ethanol solution, the iodine and polymer in ethanol solution and the quinhydron in methanol solution. In two cases a results, that are adequate to return the tested wafers in the manufacture process, were achieved.
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