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In vitro saturation study of 99mTc-HYNIC-ramucirumab on SKOV3 cell line
Klimová, Juliána ; Bárta, Pavel (advisor) ; Maixnerová, Jana (referee)
v anglickom jazyku Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biophysics and Physical Chemistry Student: Juliána Klimová Supervisor: Mgr. Pavel Bárta, Ph.D. Name of the work: In vitro saturation study of 99m Tc-HYNIC-ramucirumab on SKOV3 cell line. The passive immunotherapy is based on the use of already active immune system components (monoclonal antibodies), which play an important role in cancer cells elimination in the organism. The active immunotherapy tries to stimulate an active anticancer response via an appropriate form of an immunization. When monoclonal antibodies bind to cancer cells, those cells become a selected target for the following removal. The enhancement of the anti- cancer affect of monoclonal antibodies is possible due to the attachment of therapeutic agents like cytostatics, toxins and radionuclides. This presented master thesis is focused on the radiolabeling of the monoclonal antibody ramucirumab, which is directed against the vascular endothelial growth factor type 2 (VEGFR 2), which is often present in cells of some types of cancerous diseases. Within the experimental work, at first, there was a conjugation of chelating agent succinimidyl-6-hydrazino-nicotinamide (HYNIC) on the monoclonal antibody. After this step, radionuclide 99m...
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Nymburk sugar factory under the management of Hanuš Karlík
Fexová, Lucie ; Beneš, Zdeněk (advisor) ; Čechura, Jaroslav (referee)
The aim of this diploma thesis is to restore awareness of the Czech sugar industry tradition. For this intention I chose Nymburk sugar factory in an era, when one of the most important personas of Czech sugar industry Hanuš Karlík was its director. The thesis consists of a brief introduction to the history of Czech sugar industry, where the establishment of Nymburk sugar factory is set, followed by a description of the period when Hanuš Karlík was the director and how his administration influenced both Nymburk sugar factory and sugar industry in general. In the conclusion, there is a view on the sugar factory after Karlík left and the fate of the sugar factory that led to an infamous end. The work is primarly based on local archival sources, memoirs and newspappers. Several books about the history of Nymburk and about common history of sugar industry are used to set the topic in a wider historical context.
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Daniel Gile's effort model in simultaneous interpreting
Tauchmanová, Jana ; Rejšková, Jana (advisor) ; Čeňková, Ivana (referee)
6 Summary Simultaneous interpreting is a very complex cognitive process. Daniel Gile's Effort Model is an attempt to describe in a schematic way the various competing processes that simultaneous interpreting is composed of. The model is based on findings from cognitive psychology, especially those relating to working memory and the limited processing capacity of the human mind. It defines the process of simultaneous interpreting as a combination of three individual, yet coinciding efforts (the Listening and Analysis Effort, the Production Effort, the Memory Effort), which require a certain amount of processing capacity to assure quality interpreting performance. Problem triggers can cause saturation of the interpreter's processing capacity to occur. Saturation manifests itself either by failure sequences or by the deterioration of the interpreter's performance, immediately or at a distance. The focus of our thesis is on processing capacity saturation due to numbers in simultaneous interpreting, from the point of view of the Effort Model. The first part of our paper is theoretical and deals with the various aspects of the simultaneous interpreting process, especially those relating to processing capacity, saturation and working memory; as well as with questions of well-known problem triggers, interpreting...
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Recognition of Weather in an Outdoor Stationary Camera View
Jenčo, Michal ; Juránková, Markéta (referee) ; Herout, Adam (advisor)
This thesis deals with classification of weather from stationary outdoor camera images with a landscape view. It classifies fog, clear, partly cloudy and overcast weather in particular. The problem was solved by computing five image flags and using machine learning. Hit rate of 95% was achieved with only small variances between weather types. The main finding of this work is that it is possible to successfully differentiate between the selected weather types with the chosen set of simple image flags. The implementation of this system enables plotting a graph of weather progression during a chosen day.
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Testing of Blood Oxygenation for Pilots
Kvasnička, Pavel ; Smolík, Luděk (referee) ; Drahanský, Martin (advisor)
This work investigates the measurement of blood oxygenation for pilots, which is based on noninvasively method of pulse oxymetry. This method is based on the selective light absorption in the spectrum of infrared and red light by oxyhemoglobin and reduced hemoglobin. For measurement is crucial a pulse component of arterial blood, in which is measured concentration of hemoglobin to total amount of hemoglobin.
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Measurement of blood oxygen saturation
Schořová, Martina ; Janoušek, Oto (referee) ; Chmelař, Milan (advisor)
In the first part, this bachelor thesis deal about problems, which are connected together with measurement of blood saturation by oxigen. In this thesis is introduced description of various methods, but as the main problem is a pulse oximetry. In the second part is examination of different conditions which can create error in oxigen blood saturation measurement. These conditions has been tested to volunteers.
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Analysis of Ferroresonance Overvoltage in Electrical Net
Bátora, Branislav ; Eleschová,, Žaneta (referee) ; Krejčí, Petr (referee) ; Toman, Petr (advisor)
This thesis deals with the ferroresonance phenomenon and ferroresonance overvoltage in electric networks. That’s why the introduction part explains the theoretical basis of ferroresonance and its consequences in the power system. The work then focuses on the power system as a non-linear dynamic system and describes various analytical methods for solving these systems. These methods are further applied to diagnose specific systems. There are a number of various power system configurations susceptible to ferroresonance. The most frequent one is theoretically analyzed in this thesis and a number of recommendations are offered for reducing the ferroresonance phenomenon. The thesis further deals with the selection of suitable software for this computationally chal-lenging task. A number of different tools are considered and efficiently reduced to Matlab Sim-ulink and PSCAD software. Matlab Simulink and its SimPowerSystem Toolbox are used to ana-lyze the effect of hysteresis of the magnetic core of the transformer on the emergence and course of the ferroresonance phenomenon. Using PSCAD, various configurations of the power systems are compared in terms of possible emergence and course of ferroresonance and also to find the limiting conditions that increase the probability of this phenomenon. The possibility of using arti-ficial neural networks for ferroresonance diagnosis is also mentioned in this thesis. The final part provides a number of recommendations for design and operation of both new and existing power systems.
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The Introduction and Application of General Regression Model
Hrabec, Pavel ; Štarha, Pavel (referee) ; Bednář, Josef (advisor)
This thesis sumarizes in detail general linear regression model, including testing statistics for coefficients, submodels, predictions and mostly tests of outliers and large leverage points. It describes how to include categorial variables into regression model. This model was applied to describe saturation of photographs of bread, where input variables were, type of flour, type of addition and concntration of flour. After identification of outliers it was possible to create mathematical model with high coefficient of determination, which will be usefull for experts in food industry for preliminar identification of possible composition of bread.
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Pulse Oxymeter in LabVIEW
Synek, Josef ; Chmelař, Milan (referee) ; Čmiel, Vratislav (advisor)
One of the most important vital functions of the human body is providing sufficient oxygen to all its parts. Oxygen in the blood binds to hemoglobin and it is transported to tissues. Oxymetry is non-invasive method for measuring the amount of oxygen bound to hemoglobin. Oxygenated hemoglobin and deoxygenated have different absorption characteristics for light of different wavelengths. Therefore, pulse oxymetry transmits tissue with red and infrared light. Signal passing through the tissue is affected by the absorption properties of hemoglobin and heart pulse. These signals are measured and the ratio of their size allows us to calculate blood oxygen saturation.
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An application for color coordinate transforms and color mixing
Jurzykowski, Michal ; Štukavec, Radim (referee) ; Slanina, Martin (advisor)
The most important human sense is sight. We can see thanks to eyes, which are very sensitive on small part of electromagnetic wave. White sunlight contents all the spectrum visible. By decomposition of white sunlight we get colour spectrum. We recognize colours by cones, which are sensitive on red, green and blue spectrum of white light. Informer times it was denited many colour models, which have been using additive and subtractive method od mixing colours. One of the first models which were matemacily defined was CIE 1931, also known as XYZ. Together with this model was created xy chromatic diagram for displaying of colour space. Best known colour models are RGB and CMY. In TV technics is used model YUV. Models HSV and HSL are more intuitiv. This models have three basic parameters: hue, saturation and brightness.
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