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The Analysis of the Portrayal of the Region in the Works of the Teschen Silesian Writers via Kubisz's Writings
Kurová, Jana ; Poslední, Petr (advisor) ; Pátková, Jana (referee)
The goal of this thesis entitled The Analysis of the Portrayal of the Region in the Works of the Teschen Silesian Writers via Kubisz's Writings is to bring the life's work of Jan Kubisz-known writer, educator, and community organizer-into public discourse, and to demonstrate the aspects which have influenced both his creations and a Teschenian mentality. We begin with presenting a historical research of the region whose basis rests in Kubisz's works, primarily in Pamiętnik starego nauczyciela. We also discuss the literary characteristics of Teschenian Silesia in order to pinpoint distinctive local tendencies and issues. We proceed to examine Kubisz's approach to Germanization of the region and his handling of nationalism. The analysis of the Teschenian anthem illustrates Kubisz's legacy for the future generations. In order to facilitate the understanding of the terms used in this thesis, the additional chapter outlines their meanings and connotations. Finally, we show the impact of Kubisz's works on local population and its understanding of identity by introducing separate study and interpreting its outcomes. Keywords Teschenian Silesia, Region, Kubisz, the Issue of Nationality, Nationalism, Memorial, Identity
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The nursing process in a patient with cerebral stroke
Klimová, Andrea ; Tomová, Šárka (advisor) ; Tomek, Aleš (referee)
The topic of my graduate thesis is the nursing process and its role in the care of the ischaemic stroke patient. I was especially interested in the insufficient common knowledge of warning signs and risk factors of stroke that significantly reduces possibilities of its effective therapy. This fact is known to be one of the greatest risk factors of stroke. Thesis is divided to two parts. The first is clinical and describes consise description of cerebrovascular anatomy and physiology, etiopatogenesis, clinical signs, diagnostic procedures, complications and therapy of stroke. It is followed by detailed course and history of chosen patient example. The second part of thesis is dedicated to the nursing process. In the introduction is summarization of nursing history by Marjory Gordon, that confounds nursing diagnoses. The diagnoses including nursin plan and effectivity evaluation are described in the detail in special chapter. Separate chapter is writen about patient education. In the conclusion of the thesis is summarization of nursing process. Powered by TCPDF (www.tcpdf.org)
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Distribution of acetylcholinesteraseś reactivators after intravenous administration.
Hnídková, Daniela ; Vopršalová, Marie (advisor) ; Herink, Josef (referee)
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Candidate: Daniela Hnídková Supervisor: PharmDr. Marie Vopršalová, CSc. Title of diploma thesis: The monitoring of acetylcholinesterase reactivators distribution after intramuscular administration. Nerve agents belong to the group of OFI that irreversibly binds to acetylcholinesterase (AChE). Neurotransmitter acetylcholine (ACh) cannot be degraded and its increased concentration causes excessive overstimulation of cholinergic receptors, known as acute cholinergic crisis (Patočka et al., 2004). Reactivators of acetylcholinesterase, also called oximes, are causal antidotes for the treatment of OFI poisonings and therefore nerve agents. Their mechanism of action is to break bond between inhibitor and AChE active site and prevent its subsequent covalent binding (Šepsová, 2010). In this study pharmacokinetics of five selected reactivators of AChE (oxime HI-6, obidoxime, trimedoxime, oxime K203 and oxime K027) were monitored. Rats were used as a convenient model organism (male, tribe Wistar) for presented in vivo study. High Performance Liquid Chromatography (HPLC) was selected as the most suitable separation method to studied pharmacokinetics of oximes. In this study it was necessary to determine...
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HDO Raman spectrum
Šubr, Martin ; Štěpánek, Josef (advisor) ; Procházka, Marek (referee)
Title: HDO Raman spectrum Author: Martin Šubr Department: Institute of Physics of Charles University Supervisor: Prof. RNDr. Josef Štěpánek, CSc., Institute of Physics of Charles University Abstract: The main aim of this thesis is to determine the HDO Raman spectrum. This spectrum cannot be measured separately in its liquid form, but it is possible to obtain it by a specific mathematical processing of sets of measured spectra with different H/D ratios. In this work we measured Raman spectra of liquid water with different mole fractions of water and heavy water, which were evaluated by factor analysis. Except for well-known spectra of water and heavy water, spectrum of HDO was determined. For fitting of this spectrum and its analysis, model with equilibrium constant and linear correction of the spectral shape with respect to the relative ratio of D was used. Keywords: Raman scattering, water and heavy water, HDO, factor analysis
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TOWNHOUSE ON THE WATERFRONT IN PŘEROV
Dostálová, Lea ; Lazarov, Pavel (referee) ; Kratochvíl, Jan (advisor)
CONCEPTION - Different attitude than expected - Attempt to implement a model of so called city house which is already known for centuries in present Přerov. -Attempt to minimalize need number of parking places and their placement only on the groung. SOLUTION A result of the design is polyfunctional complex of five separate houses with following functions: housing (mayority) services, shopping, offices and religious areas.The goal of the solution is to fill up the corner between Brabansko and Malá Dlážka streets properly and avail excellent light conditions (orientation of main street facades is southeastern). With the rhytm and facade division particular objects try to distort strong horizontality of the street line. The corner is accented and thus represents the opposite of close Sokol building.
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Isolation and proteome analysis of fractions enriched in periplasmic proteins of bacterium Francisella tularensis
Kolářová, Jana ; Vacková, Jana (referee) ; Konečná, Klára (advisor)
Candidate: Bc. Jana Kolářová Supervisor: Mgr. Klára Konečná Supervisor - specialist: PharmDr. Ivona Pávková, Ph.D Title: Isolation and proteome analysis of fractions enriched in periplasmic proteins of bacterium Francisella tularensis Diploma thesis Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Biological and Medical Sciences Study field: Special worker in laboratory methods The aim of the presented diploma thesis was to test several previously published methods for preparation of fractions enriched in periplasmic proteins of bacterium Francisella tularensis. The selected method will be further used in studies aimed at finding potential substrates of hypothetical protein with homology to DsbA as several of them are expected to play a crucial role in Francisella tularensis virulence. DsbA proteins found in periplasm of gramnegative bacteria are in general responsible for disulfide bond introduction and thus for right folding and function of number of extracytosolic proteins, known virulence factors included. Tested methods included the method of cold osmotic shock, the method using chlorofom, polymyxin B sulphate, EDTA in combination with lysozyme and magnesium chloride in combination with lysozyme. The obtained protein samples were separated using...
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Images from history in creation of Alena Ježková
Němečková, Monika ; Hník, Ondřej (referee) ; Pechová, Drahoslava (advisor)
This dissertation has got a monographic character. It is targeted on the works of Alena Ježková, contemporary writer of historical books for children. This thesis goes out from selected books and provides analysis and interpretation of these works. Simultaneously this thesis deals with quality and sense of illustrations as integrated parts of works of Alena Ježková. First chapter describes the life of Alena Ježková and hers working activities related to her creation. In this chapter there is also evaluation and awards of single books of Alena Ježkova and survey of theirs translations into foreign languages. Second chapter brings basic characteristic, importance, division and development of myths. It explains differences of this genre from e.g. legends, fair stories etc. This chapter also evokes the best known representatives this genre from 19th century till now. The third chapter deals with it, how Alena Ježková picks out hers themes, why she writes just about history and what anticipates that moment when she begins to transfer her theme into book. In the fourth chapter there are single works analysed and interpreted ( myths historical and local). At the end of this chapter there are placed other three publications, which are specifically worked up, and therefore are analysed and interpreted separately....
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Extensible Collaborative Development Platform
Halaša, Michal ; Hnětynka, Petr (advisor) ; Bureš, Tomáš (referee)
Title: Extensible Collaborative Development Platform Author: Michal Halaša Department / Institute: Katedra distribuovaných a spolehlivých systémů Supervisor of the bachelor thesis: RNDr. Petr Hnětynka Ph.D., S 212, Malostranské nám. 25, Praha Abstract: Currently, there exist a number of collaborative development platforms (also known as "forges"). These platforms offer to developers a set of tools for collaborative development (e.g. VCS tools, bug-tracking tools, mailing-list managers, etc). On the other hand, there exist many standalone tools for bug-tracking, etc. Usually, these standalone tools offer more features to the developers, however they have to be set up and managed separately. The goal of this thesis is to develop a collaborative development platform (forge) that is fully extensible, i.e. it will allow developers to easily add existing tools to it and manage them in a unified way. Keywords: java, forge, extensible, development platform
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Capital adequacy of banks
Müller, Tomáš ; Dupáková, Lenka (advisor) ; Hraba, Zdeněk (referee)
This work concentrates on the issue of capital adequacy of banks. Inadequate capital base of the banking sector is often referred to as one of the causes of the latest financial crisis. Such topic is currently very actual. Even banking regulators pay high attention to this topic. In my thesis I focus on legal and economic aspects of this topic. It is typical for the banking sector that banks operate with much more leverage effect than enterprises belonging to other sectors. Therefore, I focus on the root cause of this phenomenon in the third chapter. I assess the bank indebtedness using the theory of optimal capital structure and I also address the relations between economic and regulatory capital. In the fourth chapter I focus on the concept of capital adequacy and its comparison with leverage indicator. The next chapter concentrates on the development of regulatory minimum capital adequacy standards developed by the Basel Committee on Banking Supervision, known as Basel I and Basel II. The last but one chapter focuses on the latest regulatory rules Basel III governing the capital adequacy of banks and their legal implementation. Final chapter analyzes the impact of Basel III rules on the capital structure of banks in the European Union and the Czech Republic. A separate part of the chapter is...
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Machine learning-based identification of separating features in molecular fragments
Ravi, Aakash ; Hoksza, David (advisor) ; Škoda, Petr (referee)
Chosen molecular representation is one of the key parameters of virtual screening campaigns where one is searching in-silico for active molecules with respect to given macromolecular target. Most campaigns employ a molecular representation in which a molecule is represented by the presence or absence of a predefined set of topological fragments. Often, this information is enriched by physiochemical features of these fragments: i.e. the representation distinguishes fragments with identical topology, but different features. Given molecular representation, however, most approaches always use the same static set of features irrespective of the specific target. The goal of this thesis is, given a set of known active and inactive molecules with respect to a target, to study the possibilities of parameterization of a fragment-based molecular representation with feature weights dependent on the given target. In this setting, we are given a very general molecular representation, with targets represented by sets of known active and inactive molecules. We subsequently propose a machine-learning approach that would identify which of the features are relevant for the given target. This will be done using a multi-stage pipeline that includes data preprocessing using statistical imputation and dimensionality...
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