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Application limits of sublingual drug administration. 2
Krupauerová, Lucie ; Doležal, Pavel (advisor) ; Berka, Pavel (referee)
Thesis briefly summarizes knowledge on the sublingual route of drug administration and brings newer facts about the pharmaceutical sublingual preparations, as well as basic information on dextran and its pharmaceutical use. The experiment is focused on in vitro evaluation of in vitro permeation of the dextran 40,000 (FD40S) through sublingual membrane. The acceptor phase was always a phosphate buffer, pH 7.4. To evaluate the integrity of the membranes the introducing section of caffeine permeation was used. Determination of caffeine was performed by HPLC with UV detection, the determination of dextran using spectrofluorimetry. The average values of caffeine fluxes applied at 4-hour permeation to assess of the integrity and permeation potential of the sublingual membranes were at 3 subgroups (n = 6): J = 1538.6 ± 73.4 µg/cm2 .h-1 ; J = 1540.3 ± 82.8 µg/cm2 .h-1 ; J = 1500.8 ± 272.0 µg/cm2 .h-1 No effect of six weeks storage at -ř20 C on the permeation membrane properties for the dextran molecule passage was noticed. The dextran FD40S molecule is able to pass through the sublingual membranes in vitro, however, permeation is much more variable compared with low molecular weight permeation of caffeine. The addition of 20 % polyethylene glycol 300, or 1.0 % addition of lecithin to the donor aqueous...
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The problems of the organic food in the Czech Republic
Bořkovcová, Eva ; Kořánová, Helena (advisor) ; Hůlová, Marie (referee)
The theoretical part of this diploma thesis deals with the history of organic agriculture, organic agriculture in the world, in Europe and in the Czech Republic. In terms of the Czech Republic, it focuses on the development and the current state of organic agriculture, legislative background, supervision and certification, state subsidy and the labelling of organic food. The last chapter of the theoretical part answers questions: Why should people buy organic food, and why should they prefer local organic food to the imported one? It is also concerned with the distribution of organic food. In the practical part the main problems in terms of securing the sale of organic food in the Czech Republic are detected by the means of questionnaire examination. Two types of questionnaires were created for the purpose of the research. The first type is for organic producers and the second one for the sellers of organic food and healthy food products. At the end of this diploma thesis there is a summary of the recognized problems and the forshadowing of the future of organic agriculture in the Czech Republic.
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Quality in Practice of Czech Music Therapists
Fajfrová, Jitka ; Vrzáček, Petr (advisor) ; Šimanovský, Zdeněk (referee)
Master thesis Quality in Practice of Czech Music Therapists deals with the theoretical and empirical research of the quality-in-practice-of-Czech-music-therapists phenomenon. This is realized both in the national and the European context. It develops the previous thesis Recent directions in Czech Music Therapy and focuses on monitoring the process of professionalization. Theoretical part of the thesis is divided into four sections. First section discusses the quality in general. It introduces systems of quality management and methods of detection. It gives an overview of the quality in the sectors of the economy where music therapy is implemented. Second section deals with the music therapy and especially the Czech music therapy. It replies the following questions: Who is music therapist? What are the recent directions of the music therapy? And the key personalities? It introduces current development stage in field: the stage of institutialization. Third section deals with the European music therapy and its relationship to quality. Fourth section monitors quality in the field of Czech music therapy and related expressive therapies. At the end there is a summary of some important questions and challenges for the future development of the profession. Empirical part is dedicated to qualitative...
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Evaluation meat quality in depading on condition of transfer
ČONDLOVÁ, Šárka
Work deals with transport of animals for slaughter and its influence on the quality of meat. Summarizes the right ways of loading, unloading and manipulating with animals. Determinates the precise requirements for the means of transport and transport equipment. Includes the most used transportation by road and marginally used transport by rail and water. Mentions the most common causes of injuries, deaths and losses during transport. Points to the influence of manipulations with animals on the quality of the meat. The result of improper treatment of animals are meat defects DFD and PSE, witch are commonly caused by stress and exhaustion of energy reserves. Describes the basic defects of meat of slaughtered animals-bovine animals and pigs. Mentions the basic laboratory techniques for the detection of these abnormalities.
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Current trade policy directions of Colombia
Drbohlavová, Eva ; Hnát, Pavel (advisor) ; Cihelková, Eva (referee)
Master's Thesis Current trade policy directions of Colombia is engaged in development of integration policies and its impact on the national economy and foreign trade. Emphasis is put on Free Trade Agreement Colombia -- USA, mutual trade and its evolution. United States is Colombia's most important trading partner, but their role is declining. First chapter summarizes the economic development and competitive advantages in key sectors of the economy. The largest part of the chapter is devoted to the mining industry as it forms the most substantial item of Colombian exports. The method of second chapter is analysis and comparison of integration activities undertaken by Colombia to the U.S. and other world regions (EU and Latin America). Practical part detects opinion of the Colombian business community on the Free Trade Agreement with the USA and possible deeper integration.
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Comprehensive Landscaping in Landscape Management
Humešová, Tereza ; Syrovátka, Oldřich (advisor) ; Květoň, Pavel (referee)
The aim of this work is to create cadastral municipality Lukavec proposals for measures to be focused on stabilizing the drainage conditions in this area. The means for implementation of the proposed measures are landscaping to help develop natural and cultural values of rural, environmental health, and environmental management. The theoretical part deals with the importance of drainage conditions in the country and summarizes the major and most severe impacts that disrupt water regime. The practical part is thoroughly analyzed the selected area and proposed several solutions for improving the basic functions of the landscape. These suggestions may serve as a basis for the development of comprehensive land to land the municipality. Furthermore, the detected status of the implementation plans of common facilities in the village, which has completed a comprehensive landscaping. The aim is also to find out what are the biggest obstacles in the implementation of comprehensive land. The work suggests that the importance of land consolidation as a tool to improve the environment, realizes the little people and the state is only marginal. Inadequate funding source makes the whole process of editing complex is very slow and basically lose the effect, which should yield especially in terms of landscape management. The lack of tools that would make the village-designed common facilities realize is fundamentally wrong. A major problem is too complex and confusing bureaucracy that overly complicates everything, the failure to state a limited local government. Another obstacle is ignorance, indifference and unwillingness of people to undergo this process. It is very important therefore awareness and informing people.
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Využití NIR spektroskopie při kontrole falšování kozího mléka
Ptáčková, Eva
The aim of the thesis was to find out whether NIR spectroscopy is a suitable method for adulteration control of cow and goat milk. Also to which concentration level the method is still effective was sought. Theoretical part summarizes information about the requirements for goat milk, its composition and processing possibilities. It also contains information about food adulteration and the relevant legislation. Infrared spectroscopy is theoretically described, particularly NIR spectroscopy. The experimental part describes the procedure of qualitative analysis using NIR spectroscopy, the method of evaluation and its results. Different samples of goat milk adulterated with various proportions of cow milk were compared. Results were evaluated using discriminant analysis. NIR spectroscopy has been demonstrated as a method suitable for detecting goat milk adulteration.
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Analysis of Defects on PCB Using X-RAY
Mlýnek, Martin ; Vala, Radek (referee) ; Řihák, Pavel (advisor)
This thesis is focused on BGA packages and fault detection after rework using X – Ray. There is a description of BGA packages by carrier substrate, techniques of connecting on chip, from mounting packages to repair printed circuit boards (hereafter PCB). Thesis summarizes description of defects, which are created after rework process. There is also description of X – Ray as method for analyzing defects. X – PLANE method used to detect internal structure of BGA packages and it was confirmed by microsection and by software for reconstruction. Description of automatic and manual measurement is follow.
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Development of IT Technologies in Large Corporations
Tělecká, Tereza ; Potančok, Martin (advisor) ; Vosecký, Ondřej (referee)
This Bachelors Thesis focuses on the development of IT departments in big corporations, mainly in telecommunication and pharmaceutical industries. The work aims at analyzing the week points of the IT departments in a model global pharmaceutical corporation. It suggests some measures to improve the situation and evaluates them. In the introductory part the historical development of IT technologies is summed up and, subsequently the IT development in telecommunications is described. Next part deals with specific features of the IT departments in a global pharmaceutical corporation. The last but one chapter interprets the term management, corporate organizational structures and IT management. The chapter focusing on a model pharmaceutical Pharma company is the most significant part of the work. It defines the corporation and its IT department and detects the questionable spheres. The solution for these week points is suggested and analyzed.
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