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Pyridine sulphides as antituberculotic active compounds
Sýkora, Lukáš ; Kuneš, Jiří (referee) ; Klimešová, Věra (advisor)
This diploma thesis is devoted to antituberculosis drugs research. A very briefly depicts of genus Mycobacterium, structure and composition of mycobacterial cell wall allowed here better process and determination of mechanisms of antituberculosis drugs targets. The synthesis selected derivates of pyridine sulfides: 4- (phenethylsulfanyl)pyridine-2-carbonitriles are the main aim of the diploma thesis. As well as a possible mechanism of action these substances is discussed. Thus a series of 4-(phenethylsulfanyl)pyridine-2-carbonitriles were synthesized. The structures were confirmed by IR spectra, NMR spectra and elementary analyses. Antimycobacterial activities these compounds were tested against Mycobacterium tuberculosis, Mycobacterium avium and Mycobacterium kansasii. None of prepared substances exhibited activity (against M. tuberculosis) comparable to clinical used antituberculosis drugs. Significant activity was observed (in compare with isoniazide) against M. kansasii and M. avium.
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Determination of vitamins A, D and E using sequential injection chromatography method.
Trefilová, Kateřina ; Chocholouš, Petr (referee) ; Sklenářová, Hana (advisor)
The working isntruction was created for separation vitamins A, D and E by means of monolithic column engaged in system sequentional injectional analysis. Following conditions of separation were chosen after performance of optimalization: Analysis at monolithic column 25 mm long Chromolith Flash RP-18e column, 4,6 mm I.D. (Merck, Germany), with speed (10 µl/s) with applied mobile phase acetonitril metanol (1:1, v/v). Monolithic column was in SIA system and was engaged between moreway valve and flow Z cell. Spectrophotometric detection was performed at wave length for absorbing maximum for vitamins A - 324 nm, D - 265 nm, E - 285. Total SIA analysis time was 400 s (from that 230 s lasted separation process). From basic chromatographic validation parameters were evaluated the following symetric factor As, resolution Rs, amount theoretical trays and repeatability. Symetric factor for vitamin A - 1.309; vitamin D2 - 1.302; vitamin D3 - 1.286; vitamin E - 1.158. Peak resolution for vitamins A-D2 je 3.607; D2-D3 4.232; D-E 1.532. Amount theoretical stages for vitamin A 998, vitamin D2 1621, vitamin D3 2091 and vitamin E 2376. Repeatability was worked out from 6 sprays, and relative standard deviation of particular substances was calculated from the highest point of the graph peak. Repeatability was for...
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Viscoelastic properties of microcrystalline cellulose of Avicel PH 200
Skálová, Marie ; Řehula, Milan (advisor) ; Špaček, Vladimír (referee)
In this dissertation the viscoelasticity of the most common excipient microcrystaline celulose was valuated and viscoelasticite parametres were compared to three substances. Viscoelasticity was valuated by two methods..The first method is Creep test. In this analyze the compression force is constant and hold for 180s. During this time height of the tablet was lowered. The diffrences of tablet height was noted and used for calculation in Crčel test. Parameters of elasticity got by this method are FCT1,FCT2 and parameters of plasticity are PCT1,FP. When the parameters of elasticity increase the elasticity decrease. When the parameter FP increases the plasticity increases too. The higher the value of PCT1 is the lower is the plasticity. Stress relaxation is the second method. In this analyze hight of tablet is constant and decline compression force is recorded. In this analyze we noted the decline for 180 sec. In this way we get parameters of elasticity ESR1, ESR2, ESR3 and parameters of plasticity PSR1, PSR2, PSR3. The plasticity increases when parameter P increases. Comparing three substances the elasticity increases in-line Emcompress, Avicel, Flowlac and the elasticity decreases in-line Emcompress, Avicel, Flowlac.
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Analysis of the perception of incomplete prices of travel packages in the Czech Republic
Valová, Lucie ; Petrů, Zdenka (advisor) ; Herget, Jan (referee)
The thesis deals with problems of price quoting of travel packages in the Czech Republic. It refers to the process of packaging in the theoretical part, as well to various ways of pricing together with calculation illustration and catalogues price strategy. Furthermore, it shows the difference between a company's and a customer's price perception and informs about the psychological price effect on the final consumer. The important part of this thesis represents the analysis of the current situation of the price quoting of travel packages in the Czech Republic in comparison with the situation abroad. Chapters are oriented to the analysis of the legislation in the field of packaging and price quoting of travel packages, of the praxis of Czech and foreign travel agencies and of taking action of interested institutions to solve this problem. The whole thesis is supplemented with a detailed analysis of the data extracted from the questionnaire.
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The importance and utilization of LPG in transport
Binderová, Vanda ; Dvořák, Antonín (advisor) ; Hadrabová, Alena (referee)
The importance and utilization of LPG in transport - just the title signifies what is this bachelor thesis focused on. The first part gives a chance to learn more about liquified petroleum gasses, i.e. LPG. It comprehends information about its history, compound, processing, features and also advantages and disadvantages related with this gas. The second part is concerned with the relationship "LPG and environment". You can find there answers to questions like: Why does transport have a negative influence to environment? Which substances are emitted by fuel combustion to atmosphere? Is LPG regardful of environment? The third part is an economic one. It contains the calculations of LPG purchase costs and their economic return and also the price comparison to another fuels. The main aim of this thesis is to compare LPG with petrol and diesel oil and analyze its environmental and economic efficiency.
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Detection and Laboratory Assessment of Releases of Hazardous Chemical Substances into the Environment Requiring Fire Brigade Chemical Lab Call-out
Holánová, Iveta ; Hradil, Jaroslav (referee) ; Mika, Otakar Jiří (advisor)
The diploma thesis is focused on a detection and a laboratory control of hazardous substances’ leak into the environment. These hazardous substances are classified. Further, it aims to chemical laboratories of the fire-brigade of the Czech Republic, as well as which place they hold in the fire-brigade system, and it indicates their main duties. This diploma thesis contains a review of some essential types of devices and mediums, which are in terms of the fire-brigade of the Czech Republic usable to practice the detection, determination and assessment of the hazardous substances in various figures of the environment in terrain, i.e. filling of duties of the chemical survey. The output of this diploma thesis is simulation of leaks of the toluene diisocyanate using ALOHA software, TerEx software and Rozex Alarm software. Further on, the proposal of another methodical sheet focused on leak actions of the concrete hazardous industrial substance – toluene diisocyanate. This methodical sheet could therefore broaden pro tempore elaborated sheets for chlorine and ammonia.
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Hydraulic calculation of sewage system in Lipůvka
Balas, Jan ; Raček, Jakub (referee) ; Hluštík, Petr (advisor)
Diploma thesis is focused on hydraulic assessment of Lipůvka´s sewer system, done by dynamic rainfall-runoff simulation model. Because of this fact, chapter about mathematical models is included. Commonly used programs to this actions are listed as well. Next part of the thesis describes monitoring campaign, which was done in Lipůvka and results are used to calibrate the simulation model. Hydraulic assessment of sewer system by this calibrated model was done.
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Uptake and Distribution of Chlorphenols in Barley
Jíšová, Tereza ; Forczek, Sándor ; Tesařová, E.
Chlorinated phenols represent one of the most common groups of toxic industrial compounds.\nThey are resistant to biodegradation in the environment and persist for a long time. Food crops\nsuch as spring barley, are susceptible to contamination by various pesticides and organic waste,\nand these substances can then get into the plants. Uptake and distribution of 2-chlorophenol were\ninvestigated in axenic spring barley. After absorption of 14C-labelled 2-chlorophenol, the plants\nwere harvested and extracts were analyzed for 2-CP derived radioactivity. The uptake of 2-CP to\nroots and transport to leaves were confirmed. Radioactive balance was calculated for individual\nplants.
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Model for a Fluid-Particle Breakup in a Turbulent Flow.
Zedníková, Mária ; Vejražka, Jiří ; Stanovský, Petr
A model is developed for predicting the outcome of breakup of a fluid particle (bubble or drop), which is initially deformed (e.g. due to turbulence) and breaks into two daughter particles. An initially dumbbell-shaped deformation of the particle is assumed. The evolution of sizes of particle sub-parts is calculated using Rayleigh-Plesset equations, which consider the inertia of surrounding fluid, capillary action and viscous effects. The redistribution of internal fluid in the particle is calculated using Bernoulli equation. The model computes the sizes of daughter particles after the breakup. By assuming various initial conditions (various initial shapes and initial velocities of deformation), the size distribution of daughter particles is obtained. These size distributions are qualitatively compared with available experimental data and reasonable agreement is observed. Because of strong assumptions, this model cannot be used directly for accurate prediction of size distribution after a breakup. However, it provides an insight in the physics of the breakup, especially on the effect of inner phase properties.
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