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Terbinafine-loaded biodegradable polymeric systems for topical administration
Pokorná, Tereza ; Šnejdrová, Eva (advisor) ; Dittrich, Milan (referee)
CHARLES UNIVERSITY FACULTY OF PHARMACY IN HRADEC KRÁLOVÉ DEPARTMENT OF PHARMACEUTICAL TECHNOLOGY Author: Tereza Pokorná Title of Diploma thesis Terbinafine-loaded biodegradable polymeric systems for topical administration Supervisor: PharmDr. Eva Šnejdrová, Ph.D. In the diploma thesis the released properties of solid dispersions with terbinafine, based on polyesters of D,L-lactic acid and glycol acid, branched with pentaerythritol and tripentaerythritol are studied. The theoretical part deals with solid dispersions, their classification and methods of preparation, methods of drug dissolution testing, properties, effect, use of terbinafine and preparations containing terbinafine. In the experimental part, solid dispersions were prepared by the melting method. The drug was incorporated into the polyester in the form of a hydrochloride or a base in a concentration of 10 % or 20 %. Some systems were plasticized with 30% triethyl citrate. Thin layers were formulated from solid dispersions, and drug dissolution tests were performed on phosphate buffer pH 7.4 at 37 řC. Assay of terbinafine released was performed spectrophotometrically at 223 nm and ultra-high performance liquid chromatography. Based on the results of this diploma thesis, it can be clearly stated that the suitable carrier of terbinafine...
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Usage of of common reclaimed asphalt in asphalt mixtures
Přívara, Jakub ; Coufalíková, Iva (referee) ; Dašek, Ondřej (advisor)
The bachelor thesis is focused on adding of RAP (reclaimed asphalt pavement) to the wearing asphalt courses flexible pavements. Specifically it is SMA 11S asphalt mixture. The theoretical part describes issues of ecology and recycling. The practical part deals with bitumen recovery from SMA mixtures with different added ratios of RAP and assessment of basic empirical and functional tests on the bituminous binder. The verification of properities of modified bituminous binder used in this quality SMA mixtures is also introduced.
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Optimized manufacturing of aluminium castings by using lost wax technology
Talanda, Ivan ; Horenský, Jiří (referee) ; Horáček, Milan (advisor)
Aim of this diploma thesis is to choose new pattern wax for Fimes a.s. foundry. New wax should substitute old not fully satisfactory pattern wax which caused problems in technological process resulting in increased number of rejects. New pattern wax should eliminate current problems and help foundry with producing large, thin-walled, high-quality castings. Numbers of pattern waxes supplied by world’s leading wax manufacturers were subjected to laboratory tests and pilot study. This diploma thesis is part of project Alfa TA01010766: „Research and development of production technology large, thin and high quality castings of aluminium alloys “
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Study of properties of concrete with "green cement"
Matyk, Tomáš ; Dorazilová, Irena (referee) ; Bodnárová, Lenka (advisor)
The thesis focuses on collecting available information about possible ways of using and usage restriction of portland blended cements and portland cements with limestone for production of concrete. The experimental part of the thesis describes the behavior of portland blended cements and portland cements with limestone in aggressive environments. Furthermore, the thesis concerns the dependence of rheological properties of cement pastes of portland cements and portland cements with limestone on type of plasticizing additives.
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Reactions of HDPE in the melt initiated by peroxides
Hampapa, Břetislav ; Kučera, František (referee) ; Petrůj, Jaroslav (advisor)
The thesis deals with HDPE modification by crosslinking. In the theoretical part, data available in the literature were reviewed. Modifications of the selected HDPE copolymer grade were carried out in a kneading device Brabender using 25 ml chamber size. After having optimized process conditions, there were performed a series of experiments in dependence on concentration of the initiator. Reological properties of polymer samples were investigated by melt flow indexes measured under different conditions. Changes in crystallinity and melting temperatures were evaluated from DSC heat flow measurements. The samples meeting characteristics supposed were selected for measuring complex viscosity on the Rheometer AR-G2 TA and for testing some mechanical properties on the device Zwick.
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Properties of cementitious composites with plasma treated polymer fibers
Počekajlo, Václav ; Hela, Rudolf (referee) ; Bodnárová, Lenka (advisor)
Modification of polymer fiber low temperature plasma is one of the ways to enhance the properties of modified fibers as follows. This work aims to evaluate the effect of plasma treated polypropylene fibers on the rheological properties of cement composites. The theoretical part describes the treatment and the effect of plasma treatment on polymer fibers. The influence of polypropylene fibers treated by low-temperature plasma on the workability of concrete. The practical part is described and evaluated experimental verification of the influence of the addition of commercially available fibers and fibers treated plasma on the rheological properties of fresh cement composite.
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Spinnability of PEO solutions with respect to their aging
Zelenková, Jana ; Peer, Petra ; Filip, Petr
Non - negligible portion of pol ymer commodity suffers from ageing that participates in sometimes significant changes of products attributes. Rheology represents a useful tool for a description of this process. The aim of this contribution is to evaluate possible ageing of PEO solution ( polyethylen e oxide ( M w =300,000 g/mol) dissolved in water at 10 wt.% concentration) based both on rheological characterization and on quality of electrospun fibres. Rheological measurements in steady shear and oscillatory modes were carried out using a rota tional rheometer MCR 501 (Anton Paar, Austria) equipped with the concentric cylinders geometry. The electrospinning measurements were executed with the help of a proposed laboratory device. The tip - to - collector distance attained 20 cm, applied voltage rang ed from 20 to 30 kV. The obtained electrospun fibres were analysed using a scanning electron microscope (VEGA 3, Tescan, Czech Republic). Both types of measurements were carried out in the period of several months during which the solution studied was plac ed in a dark and tempered box (25°C). The measurements indicate no ageing impact on rheological characteristics or quality of electrospun fibres. This guarantees more or less the identical quality of non - woven textiles prepared from PEO solutions regardles s of time period during which the solutions are deposited.
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