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Study of biological activity of isolated alkaloids from Corydalis cava (Fumariaceae)
Chlebek, Jakub ; Opletal, Lubomír (advisor) ; Drašar, Pavel (referee) ; Kuča, Kamil (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Botany and Ecology Candidate: Mgr. Jakub Chlebek Supervisor: Doc. RNDr. Lubomír Opletal, CSc. Title of Doctoral Thesis: Study of biological activity of isolated alkaloids from Corydalis cava (Fumariaceae). Key words: Corydalis cava, isoquinoline alkaloids, DPPH, AChE, BuChE, BACE1, IMER. Tubers of Corydalis cava were selected on the basis of bio-guided spectrophotometric Ellman's method as a source of isoquinoline alkaloids for study of their selected biological activities. The tubers of Corydalis cava were extracted with ethanol and the mixture of summary tertiary alkaloids (fraction A) was fractionated in silica gel chromatography column using step gradient elution with hexane, chloroform and ethanol. Repeated column chromatography, preparative TLC and crystallization led to the isolation of fifteen isoquinoline alkaloids. The chemical structures of isolated compounds were determined on the basis of spectroscopic techniques and by comparison with literature data. Isolated alkaloids were tested on ability to inhibit AChE, serum BuChE (IC50), BACE1 and for its free-radical scavenging activity (EC50). The cholinesterase inhibitory activity was determined in vitro by modified spectrophotometric Ellman's...
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Detached house with an establishment
Palla, Roman ; Rybaková, Anna (referee) ; Utíkalová, Ivana (advisor)
Abstract This bachelor‘s thesis focuses on design of detached house with a wine shop situated in town of Žadovice near Hodonín. The documentation of this project is elaborated with regard to contemporary Czech legislative and standards. The house is situated on a plot number 1245/75 in Žadovice. Near the house is located roadway and common infrastructure. In front of the building is a paved driveway and parking spots for customers of the wine shop. It is a double floored building with one flat suitable for 4 inhabitants, a wine shop and a garage for one 1a class vehicle on the ground floor. Buildings groud floor is an irregular shape with dimensions 17,35 by 15,85 meters. Foundations are made from plain concrete. Vertical supporting structures are made from Porotherm blocks. Ceiling is made from reinforced concrete girders with Porotherm ceiling blocks. The object has a gable roof which consists of wooden trusses and over the wine shop and the garage is an aisle roof. The ceiling is made from gypsum plaster panels with thermal insulation fixed into the roof trusses. This thesis contains study works, project documentation plans and reports, heat engineering calculations, fire safety report and semester project which consists of 5 detailed drownings.
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The Analysis of Communication Activities of Junák Organisation in 2011 on the Example of National Charity Events
Höschlová, Aneta ; Halada, Jan (advisor) ; Ježek, Jiří (referee)
Bachelor thesis entitled The Analysis of Communication Activities of Junák Organisation in 2011 on the Example of National Charity Events deals with the largest educational organization in the Czech Republic. The aim is to introduce the organisation Junák - svaz skautů a skautek ČR in terms of its mission, history and current status. It contains an analysis of communication activities of the non-profit organization, which is focused on the analysis of media coverage and communication tools that this non- profit entity used the most. In the second part, this bachelor thesis deals with charity events of non-profit organizations and describes in details four national charity events of the scout movement - Betlémské světlo, gatherings Postavme školu v Africe, KAPKA and Velikonoční skautské kuřátko, then compares their sense to the mission of Junák and its communication strategy. The last part focuses on primary research carried out by the author of this work on the target group of respondents aged 15 to 26 years. The research examined whether the organizing charity events affect the image of non-profit organizations, whether charities are perceived differently by people who went through scout education and those who were never scouts, whether these current scout charity projects are meaningful and...
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Comparative analysis of loans to finance housing
Halász, Stanislav ; Radová, Jarmila (advisor) ; Rajl, Jiří (referee)
My thesis focuses on the analysis of financial instruments suitable to finance own housing available in the Czech Republic, especially on mortgages, building savings loans and consumer loans, from the client's perspective. The first chapter presents these three selected options, describes them along with their most important parameters. The second chapter presents three main financial groups in the Czech Republic alongside with their selected products. Individual products are compared and evaluated using preselected examples: buying a property and a reconstruction. Last chapter describes the most common influences on the demand for loan products to finance own housing and analyses them, focusing on the interest rates and the inflation rate.
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Comics Rychlé šípy in Mladý hlasatel and active audience
Mamulová, Martina ; Švelch, Jaroslav (advisor) ; Suk, Pavel (referee)
Diploma thesis "Readers of Rychlé šípy comics and Mladý hlasatel reader's clubs as an active audience" deals with a confrontation of modern theories of the active audience and reconstruction of active fans of comics Rychlé šípy which was published in th Mladý hlasatel magazine. Theoretical part of this paper characterize this magazine for children and its time context. I focused on a development of passive and active audience concepts. There are also introduced modern approaches to active audiences like produsage, collective intelligence and transmedia storytelling which are compared in the practical part of this work with the reconstructed activity of Mladý hlasatel readers. The target is to find the common features of this moderrn approaches in their activity. I also described the audience of the Mladý hlasatel in details and its types of activity. The very last part of this thesis is dedicated to Henry Jenkins' "fandom" as it was described in his piece Textual Poachers. I was able to find there many of the similar features of Jenkins' fan and fan of Rychlé šípy, although the Jenkins' book was published in 1992 and Mladý hlasatel in the thirties of twentieth century. My conclusion is that modern theories such as produsage, collective intelligence and transmedia stotelling do fit in many ways to...
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Motivating and mobilizing elements in music activities of children
Kautská, Klára ; Váňová, Hana (advisor) ; Kodejška, Miloš (referee)
The topic of my bachelor essay is an inventory of motivational and activating elements/components in music activities for chlidren at preschool age. The theoretical part deals with motivation and activity in general.lt defines basicconcepts such as motivation,motive,motivation on music akactivities, activity, activation, and activating level relating to preschool education. These elements are shown in practice in the second part where the efíectivenessoťthe chosen motivational and activating elements is verified. Powered by TCPDF (www.tcpdf.org)
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Proceedings of multidisciplinary conference LASER56
Růžička, Bohdan
Conference LASER56 is a multidisciplinary and intersectoral event where different kind of specialist can meet each other. They come from various environments (private company, university, public research organization etc.). Their common denominators are laser, optics and its applications.\n\n
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The Institution Of Leisure Activities Youth Up To 18 Years Old
Kovářová, Kristýna ; Polišenský, Miroslav (advisor) ; Lörinczová, Enikö (referee)
This bachelor thesis is focused on an institution of spending leisure time of youth up to 18 years. The theoretical part, firstly, sets out terms, like teenagers and factors. The first describes every phase of a child's age, and the second an influence on child's upbringing. Next, the thesis defines the function of upbringing and it's method, which also includes negative factors influencing leisure time. A certain scope is dedicated to the function and participants of teenager's leisure time, who are integral constituents. The description of nonprofit organizations of spending leisure time of youth, which one can also encounter, is also included in this part. The theoretical part is concluded by funding these institutions, and by possibility to get grants and funds. At beginning, the practical part deals with characteristics of Municipal part Prague 3, the it concentrates on "Dům dětí a mládeže Praha 3- Ulita". The institution is examined by Bronislaw Malinowski's analysis, which was published in his book "A Scientific Theory of Culture and Others Essays". The analysis survey if the institution has enough space for organizing its activities, if the offer of activities is sufficient, if the staff is qualified, and if they have sufficient resources for their activities. The aim of this thesis is to find out whether the institution performs its mission according to its purpose and in accordance with law.
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Institutions for Leisure Time Spending of the Youth up to the age 18
Hyršlová, Iveta ; Polišenský, Miroslav (advisor) ; Gabriela, Gabriela (referee)
The diploma thesis deals with the institutions for leisure time in the capital city of the Czech republic. This is a House of children and youth, whose founded by the capital city of Prague.The thesis is divided into two parts, theoretical and part of the research. In the first part of the thesis is defined by the concept, development and function of leisure time and different views on leisure time. Is indicated here, what does the pedagogy of leisure time mean. A large section is devoted to institutions and institutions for leisure time. Defined forms of institutions for leisure time activities and their functioning. In the theoretical part is explained what is meant by universal institutional structure, which is an important basis for institutional analysis in the research section. The research part of the thesis deals with the characteristics all the information about the House Children and Youth in Prague 7. The most important part of the research is the analysis of the institutional follow-up to the House of children and youth. The aim is to assess whether and the extent to which the institution carries out its percent of the mission. In the final discussion summarizes the recommendations that could lead to improve the operation of the institution.
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Detached House Tichých
Tichá, Kateřina ; Lampa, Martin (referee) ; Smolka, Radim (advisor)
The subject of the bachelor thesis is a design documentation for detached house with a workshop. The object is situated in the South- Moravian region, in the city of Prštice. Detached house is designed as 6+kk and planned as a three-story building, with two above-ground floors and a basement. The workshop, which serves as a design office, is in the basement, with its own entrance from the west side of the plot. Besides of the design office, there is also toilet, and a bathroom in the workshop. Design office and family house are connected by a staircase. Main entrance of the family house is on the north side of the house. There is entrance for pedestrians and drive way to the garage as well. Entrance for pedestrians leads to wind lobby, from where is an entrance to the main hall and to the garage. There is staircase nearby main hall, which connects all floors. On the first floor there is a common part of the house with living room, kitchen and dining room. On the second floor there is a resting part of the house, with bedrooms for all family members and with a study. Vertical load-bearing structures are made from clay blocks. Horizontal load-bearing structures are composed from clay inserts and there is a mono pitched roof split into two parts. Above the garage, there is a walkable flat roof.
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