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Antioxidative effects of the analogues of nucleic acid components.
Procházková, Eliška ; Mertlíková Kaiserová, Helena (advisor) ; Zusková, Iva (referee)
Reactive oxygen species (ROS) naturally occur in the organisms where they play e.g. signaling and antimicrobial roles. The imbalance between ROS production and removal results in the oxidative stress. This condition is largely considered as unfavourable leading to the oxidative damage of the biomolecules (lipids, proteins, nucleic acids). The oxidative stress accompanies a number of civilization diseases and may also arise as a consequence of pharmacotherapy (side effects of some drugs). Modulation of the oxidative stress with the use of antioxidants remains a subject of intense research. The analogs of nucleic acid components represent a structurally diverse class of compounds with important pharmacological potential. While their antiviral and cytostatic activities have been described in detail, information on their potential antioxidant activity is missing. The aim of this study was to identify the antioxidant activity in a series of 126 analogs of nucleotides, nucleosides and nucleobases and to describe structural motives responsible for this activity. Several methodological approaches have been used to reach the goal: 1) determination of the ability of the compounds to scavenge ABTS radical in vitro (TEAC), 2) the influence of the compounds on lipid peroxidation and 3) their ability to...
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The effect of extreme physical exertion on the percentage of dendritic cell subpopulations in professional athletes
Bočínská, Helena ; Radvanský, Jiří (referee) ; Kolář, Pavel (advisor)
The main goal of this tesis is to describe changes in representation of various subpopulations dendritic cells (myelogenic and plasmocytoigenic) in peripheral blood after intense physical stress and to review their activation status. Early count changes and changes of function of basic elements of cellular immunity after a sport load was described, whereas a behaviour of circulating dendritic cells hasn't been studied yet. The amount and the stage of differentation of dendritic cells was specified by analysis of blood samples taken before and after the load. According to the result of the tesis the reaction to extreme physical load had two effects. The amount of dendritic cells was increased, whilst the expression of kostimulative molecules (their activation) was decreased. Described changes support an opinion, that physical load initates reaction to a danger of body damage. Powered by TCPDF (www.tcpdf.org)
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The problems of the technical and tactical skills in a training of young football players
Fanta, Miroslav ; Buchtel, Jaroslav (referee) ; Buzek, Mario (advisor)
Name of the task: The problems of the technic and tactics skills in a training of young football player Object of this task: My aim in this work is to describe problems in a training football players at the age of 10 - 12 regarding technic and tactics skills in foreign football school and to compare its approaches with the football school in Czech Republic. I decide to use qualitative method for this research. In the conclusive part I deduce the results of the trainig process based on the developed facts and I propose the alternation to contemporary approach in the conception of the training young football players. Method: It is qualitative research which used datas collecting information from a special and professional literature, specialized and experts Czech and foreign books, scientific magazines which are avalaible in the UK FTVS Library and the databases like Medline, ERIC a Sport Diskus and public accessible internet documents. Findings: The description of the training technic and tactics skills (mainlypractices and improvement). The results of this work are useful as a base for a training the football players at this age category. Key words: technic and tactics skills, foreign academy, age category, trainig, coaching,
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European Commission programmes for the support of small and medium enterprises
Vorčáková, Eva ; Černohlávková, Eva (advisor) ; Vondrák, David (referee)
Small and medium enterprises are very important for the european economy from the view of their quantity, creation of jobs and the added value.In the first part of my thesis I'm introducing the definition of the small and medium enterprises according to European Commission, their importance, strenghts and weaknesses. Another important issue is also the business environment in the Czech republic, which is the main attribute of the development of SME. The second part is about the main types of SME support of European Commission, like the finance and non-finance help, direct help and structural funds. In the third part I will present the impact of the current economic crisis on SME and the steps of European Commission and Czech government which are being taken to help SME. At last, I am introducing succesfull medium company named VARI, a.s. and external and internal factors which help the company to be successful on the Czech market.
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Results of transformation in the Russian Federation until present.
Aschmannová, Ivana ; Adámková, Vlasta (advisor) ; Popovová, Marie (referee)
The main aim of my bachelor thesis is to describe process of transformation in Russian Federation from centrally planned economy to market economy. Paper is focused on system reforms like price liberalization, liberalization of foreign trade, privatization and macroeconomic stabilization, in which I mainly focused on financial crises in Russia. I aslo focused on the area of direct foreign investments which is important part of transformation process. I worked with information from Centrally bank of Russia and also from russian Bureau of Statistics named Goskomstat. In some cases they considerably differ that is why I also used statistics from international organizations.
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The role of international community in the post-conflict reconstruction and development of Afghanistan during the transition period
Jemelíková, Veronika ; Karásek, Tomáš (advisor) ; Střítecký, Vít (referee)
Security, economic and societal challenges of the 21 century place demands on international community and deepens the need to precisely define this term and its role in the global development as well as the legitimacy of international organization, which often place themselves as representatives of the entire global community. Conflict in Afghanistan and its reconstruction is a great case study of mechanisms, which allow the international community to assess security challenges, apply former experience to respond and prepare for future operations. There are many lessons that can be learned from the case of Afghanistan. This article addresses the successes and failures connected with Afghan reconstruction and stabilization efforts and its impacts on development of the country. The article stresses the negative consequences of the international involvement as well as the deepening dependence of Afghanistan on foreign assistance.
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Kinesiotherapy and Healthy Nutrition Under Treatment of Overweight and Obesity
Merunková, Ludmila ; Hátlová, Běla (advisor) ; Hošek, Václav (referee)
Name of the work: Kinesioth~rapy and healthy nutrition w1der treatment ofoverweight and obesity Objectives of the work: Familiarizativn with kinesiotherapy, obesity, healthy nutrition and possibility oftreatment in term ofpsyche and movement The main objektive ofthis work was to map the lifestyle (nutrition and motional habits, alcohol and stress) inhabitants ofChcb's borderland. Method: Read up specialized publicat10ns and other mtormation sources ( internet, lectures, journals) concerning subject matter. After obtaining sufficiency of informations the theoretical part were created. Ihe practical part is set in on the basis of questionnaire survey, where were taking part 103 respondens (57 Czechs and 46 Germans) suttering from overweight and obesity. After this followed the creating of recording forms and tables, where were the results from questionnaire incribed. Obtaii:J.ed data were analysed and transfert;d tu diágrams. Tne particular results hati lx;en j udgt!d by fonn of discussion from whom was appointeů the resuit. Results: Healthy nutrition and sufficient measure of movement is the basis of successful tabescence. Germans either Czechs between the ages of 40 and 60 have lowered movement activity and their nutrition ways would need to be changed so that their weigh reduce. The results of...
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Yoga - Antistress System
Lošťák, Jiří ; Potměšil, Jaroslav (advisor) ; Čichoň, Rostislav (referee)
Name of the thesis: Yoga-anti stress system Goals of the thesis: Today's hasty time brings lots of negative impact on humans. People are always busy having no time for themselves especially for their body and mind. The goal of this thesis is to prove a positive impact of yoga exercise on human body and mind. Other impact involves stress elimination. By the help of this thesis I would like to demonstrate that an everyday yoga implementation can lead to a total anti stress and relaxing way oflife without any stress response. Methods: The thesis is based on a specific yoga exercise targeted at body and mind stress elimination. This exercise was done by pre-determined groups of di:fferent-age yoga gymnasts (either beginners or intermediate ones). The beginners were examined with the help of interviews, observation or questionnaires in a given time span (6 months). At the beginning of the research a form was filled in with appropriate data and after six months the process was replayed. Afterwards, on grounds of given data proper changes in questionnaire points have been analysed. Other interviewees undergoing the research comprised yoga non-practising individuals, intermediate yoga gymnasts and advanced individuals. The research of these groups was based on a comparison method (condition before the...
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Process analysis
Pospíchalová, Lenka ; Veber, Jaromír (advisor) ; Řepa, Václav (referee)
The goal of this work is to analyze processes in the market of advertisement. Then I will make some advices for analyzed companies and for potential new firms in this market of advertisement. If I want to analyze all this market then I had to use two companies one which name I can't write and Centrum Reklamy s r.o.. In the first theoretical part of this work I will describe: what the process directing is, then and how that emerged, what is process and how can be divided. In the second practical part o this work I will analyze processes and objects in the first unnamed company and later in Centrum Reklamy. In next part I will make some advices for both firms and at the end I will make some general advices for potential new firms.
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Expression of Kunitz-type recombinant protein, potential toxin from the salivary glands of the tick \kur{Ixodes ricinus}
CERMANOVÁ, Tereza
Ticks feed on their vertebrate hosts for number of days, providing enough time for development of an effective immune response. To overcome this, tick saliva contains a complex mixture of active substances which mediate host defense mechanisms. Extremely important role at the tick-host interface is played by the protease inhibitors. In this work, we have focused on the protein named Ixocludin 2, a member of the Kunitz type/Bovine trypsin inhibitors of serine proteases, related also to the potassium channel blockers toxins. Three different expression systems (Escherichia coli, Chinese hamster ovary and Pichia pastoris) were tested to prepare an active recombinant Ixocludin 2, out of which, only bacterial system was in part successful.
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