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Satisfying of Spiritual Needs of Mentally Handicapped Persons
Brusová, Kamila ; Sivek, Vojtěch (advisor) ; Jandejsek, Petr (referee)
Man ́s behaviour is made from his needs. We all know very well saying that beeing a man means unity of body and spirit. If we speak about such unity, we must admit we are not made only from biologic items, but we have the psychic and spiritual proportion in the same time. My work discuses this splitting more exhaustively. Every man needs not only to live biologically, but also psychologically and spiritually. I devote my work especially to spiritual needs of people. I focused my attention even on mentally handicapped persons. I did not want only to trash spiritual needs of these people out, but my theses are devoted especially to satisfying such wants. In the practical part of my work I speak about a concrete organization in which I was working. I have to submit that spiritual needs of mentally handicapped people are smallDscale, limited, narrow. Therefore I spoke in my theses just about this problem and about the ways how the organisations of mentally handicapped persons can work. Powered by TCPDF (www.tcpdf.org)
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Influence of temperature and stimulus intensity on FAD transience in rat hippocampal slices in vitro
Rous, Matouš ; Otáhal, Jakub (advisor) ; Konopková, Renata (referee)
Aims: The purpose of this study was to characterize the influence of temperature and stimulus intensity on flavoprotein autofluorescence in rat hippocampal slices. Methods: Experiments were performed in hippocampal slices of adult male Wistar rats. Slices of 400 µm of thickness were maintained in submerged recording chamber, through which oxygenated ACSF was perfused (2 ml/min). Synaptic activation was being made by bipolar stimulating electrode (10s stimulus train 20Hz) placed in hillus of the dentate gyrus (Mossy fibers). FAD signals were detected by cooled 12-bit CCD-camera (RETIGA2000R). Results: Our findings demonstrate that FAD autofluorescence signals were significantly decreased at higher temperature. The data confirmed that FAD autofluorescence signals showed smaller light intensity in different layers of CA3 under the same conditions at 36řC compared to 26řC. Our data approved that under defined conditions FAD fluorescence signals have risen during stimulation. Keywords: Mitochondria, FAD autofluorescence, temperature, stimulus intensity, hippocampus, rat.
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Expression of different forms of actine in some non-muscular and muscular tissues and tumors
Dundr, Pavel ; Povýšil, Ctibor (advisor) ; Marek, Josef (referee) ; Mačák, Jiří (referee)
Actins are ubiquitous eucaryotic proteins. Actin filaments are involved in diverse functions which include cell contraction, motility, adhesion, division, cell shape maintenance and muscle contraction. Four actin isoforms are tissue specific (α-smooth muscle actin, α-cardiac actin, α-skeletal actin and γ-smooth muscle actin). Two other actin isoforms (cytoplasmic β- and γ-actins) are ubiquitous. Alpha-smooth muscle actin (α-SMA) expression is typically found in vascular and enteric muscle tissue, in myoepithelial cells, myofibroblasts and pericytes. However, expression of this actin isoform could be detected in a variety of other cells and tumors with a preexisting different phenotype. Our study focused on the expression of actin isoforms in some muscular and non-muscular tissues and tumors. The goals of our study were: 1 Analysis of actin isoforms expression in normal, osteoarthrotic, posttraumatic and transplanted cartilage. 2 Analysis of actin isoform expression in some non-muscle tumors. 3 Analysis of actin isoform expression in uterine leiomyomas after therapy and in leiomyomas with inclusion bodies of the gastrointestinal tract and uterus and the detailed analysis of inclusion bodies. A total of 82 samples of cartilage, 591 samples of neuroectodermal tumors, 87 cases of breast carcinoma, and 29 cases...
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Effect of sound on health
Dorková, Lenka ; Hrnčíř, Evžen (advisor)
Sound , whether in a positive or negative effect on man every day of his life . Since coming to the world around us different sounds , pleasant voice from the mother to the noise from automobile traffic outside the window . The sound then accompanied us for the rest of our life , allows our communication is a means of pleasant sensations . Unfortunately, the majority of the population moving into large agglomerations , the development of technology and transport in our daily life we encounter at every step too noise and unpleasant consequences. In my thesis , I would like to address the deeper issues of sound and its effect to humans. In the first chapter, I outline the physical nature of sound, to address the basic physical concepts related to sound and acoustics and briefly bring even the structure of the human auditory system, which allows us to register the sound around us and analyze . In the second chapter, I will own sound effects to humans , the definition of noise, to think of its source and paid to the effects on the human body . I would also like to further analyzed Czech legislation dealing with noise and its health limits . In the second part I will discuss the positive effects of sound , especially on behalf of music and its therapeutic effects , ie music therapy. The aim of my work is to...
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Depressive symptomatology of the children
Karlovská, Soňa ; Vaníčková, Eva (advisor)
Conventional wisdom adults is: 'Children are happy, play, do not our worries, workload, and the pains they just pofoukat. "This naive idea of a happy and joyous childhood is long refuted Prejudice as well as the notion that although the child is often sick,but only physically and mentally very rarely. Depression in childhood occursrelatively often, however, is more often associated with behavioral disorders, aggression and various somatic complaints than the symptoms of depressivedisorders adults. Still have depressed children and adolescents similar symptoms as adults: they can not be happy, have low self-esteem, feelings ofsuffering guilt, have at times sad, hopeless mood (with thoughts of death)are irritation, lonely, socially isolated, sometimes aggressive, restlessand hyperactive, sometimes tired, silent, slow with many somatic or vegetative symptoms. a The aim of this thesis was to determine the frequency ofcertain symptoms of depressive syndrome in children, focusing onadolescents with to highlight the significance and importance of active research, early detection, diagnosis and initiation of preventive measures, or.treatment developing mental disorders. Without proper intervention is a risk serious consequences of depressive illness, such as suicide or continuity of depression in adulthood, very high.
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Occupational Diseases in the Czech Republic
Baciak, David ; Hrnčíř, Evžen (advisor)
Occupational Diseases (NzP) are diseases whose definitions is defined by current legislation. The definition is based on Law No. 65/1965 Coll. Labour Code, as amended, Act No. 155/1995 Coll. pension Insurance, and Government Regulation No. 290/1995 Coll.establishing list of occupational diseases, divided into 6 chapters (see Annex No. 1). I Occupational diseases caused by chemicals II Occupational diseases caused by physical factors III Occupational diseases of the respiratory tract, lungs, pleura and peritoneum IV of occupational skin disease In Infectious and parasitic illnesses VI Occupational diseases caused by other factors and actors Each chapter represents a group of professional disease, which is either a common etiological factor (chemical, physical or biological, that is infectious noxa) or disability such a body, which is particularly exposed to influences work environment (skin, respiratory system, musculoskeletal system). Each chapter is then further divided into different number of items that represent nosologickou unit or group of related or diseases include diseases caused by the same etiological noxou professional.
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Prevention of mastitis and factors affecting somatic cell counts in milk of cows
Lebedová, Šárka ; Toušová, Renata (advisor) ; Stádník, Luděk (referee)
This thesis focuses on a mastitis, or inflammation of the mammary glands in herds of dairy cattle and the somatic cells in milk.
At the beginning is described mammary gland and milk composition. After characterization of mastitis and their differentiation by typical symptoms, ie subclinical and clinical forms. Mastitis are among the highly costly disease of cows, because of the economic consequences, which include negative changes in quality of milk, decreased milk synthesis, the financial cost of veterinary treatment and drugs, higher intensity decommissioning cows from the productive group. Following is an overview of pathogens and characteristics of the most common causes of mastitis. Described are also immune function of the mammary gland and mechanisms that occur in the mammary gland during penetration of pathogens whose mission is to destroy microorganisms. They describe the three main risk factors: pathogen external environment, cows, whose interaction is a precondition for the onset of inflammation. The following is an overview of preventive measures, which include milking teat disinfection, housing, nutrition, drying off cows and the possibility of selection for resistance to mastitis. Then there are methods for the diagnosis of mastitis, which detects the number of the somatic cells, the concentration of enzyme and lactose. Further described is the treatment of sub-clinical, clinical mastitis and prevent the occurrence of resistance to antibiotics.
The conclusion is devoted to somatic cells, which are mostly made up of white blood cells and epithelial cells. Among the factors influencing the quantity of somatic cells include: pathogens and the level of infection, milk production, age of cows and stage of lactation influence the seasons etc. Most of the somatic cells reflected the presence of pathogens in the milk, it causes inflammation, which is accompanied by migration of white blood cells from blood in milk.
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Impact of the application of the insecticides on the diversity of ground beetles (Carabidae) in a winter rape stand
KEPL, Lukáš
This thesis deals with the determination of the direct impact of spraying on soil invertebrates by comparing the treated and untreated surfaces by spraying with plant protection products. The experiment took place in crop of winter oilseed rape in the western part of South Bohemia in spring 2012. As bio-indicators were used ground beetles beetles (Carabidae). Trapping was conducted using pitfall traps. In this work we compared the difference in the occurrence of ground beetles in treated and untreated crop of winter oilseed rape and subsequent tree alley. Only 15% of beetles was recorded sprayed areas, 69% in untreated areas and and 16% in the alley. This suggests the direct impact of spraying on non-target organisms. That's followed by a second experiment, which aim was to determine the long-term effects of intensive farming on ground beetle populations in habitats related to reporting rape field. The selected habitats were meadow, pasture, alley, ruderals and riparian vegetation. The results indicated the inportance of the biotops consequent to field as tthe refugium and the center of spreading of groujd beetles to the field where they provide ecosystem service of biological control.
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The incidence of secondary tumors after irradiation for carcinoma of the uterine body.
TESAŘOVÁ, Lenka
ANNOTATION: Malignant tumours of the corpus uteri are among the most frequently occurring gynaecological conditions. Endometrial carcinoma represents 96{--}98% of all malignities in corpus uteri tumours. Occurrence of this condition in the Czech Republic: in 2007, 1726 new cases were diagnosed, which represents approximately 32.7 cases per 100 thousand women. Almost 75% of the patients are diagnosed in the first stage of the disease. The age median of the patients with a diagnosed tumour of the corpus uteri is 61 years. Secondary tumours occur from mutations several years after radiation exposure. They result from the previously administered chemotherapy or radiotherapy leading to the damage to the genetic information in the cells. The mutation affects the cells that relate to the formation of secondary malignities. The aim of my bachelor{\crq}s thesis is to find out about the occurrence of the secondary tumour with cancer of the corpus uteri among those who received radiotherapy at the Department of Oncology at Hospital České Budějovice between years 1978-98. In my thesis I evaluated the number of secondary tumours, time of their occurrence, relative risks, and whether they are located within or outside the irradiated field. The thesis is divided in two main parts: a theoretical part where I deal with the tumour itself, radiotherapy, and radiobiology; and a practical part that presents concrete statistics issuing from the aim of my work. I found out that secondary tumours occur more frequently outside the irradiated area. The results suggest that secondary tumours may occur from the effects of the ionising radiation on the organism. This probably relates to the fact that there are lethal changes within the area exposed to radiation whereas in areas receiving low doses of radiation the cells are damaged, which may, after many years, lead to the occurrence of secondary tumours. I chose this topic also to emphasise the fact that besides the curing of the primary tumour one also needs to pay attention to dispensing a routine that may aid the early detection of further tumours
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Versatile use of liquid chromatography and mass spectrometry in drug metabolism studies
Suchanová, Bohumila ; Wsól, Vladimír (advisor) ; Solich, Petr (referee) ; Lemr, Karel (referee)
Human organism has always been exposed to a vast array of chemicals encountered in the environment. Chemical revolution has significantly influenced biological evolution of humans leading to serious unpredictable toxicities. In response to continual chemical stress they have developed a variety of enzymes to transform these xenobiotics. Xenobiotics are mostly highly lipophilic and cannot readily be excreted from the body without metabolism to more hydrophilic, water-soluble metabolites. Not only environmental chemicals represent xenobiotics but also drugs, dietary components etc. Biotransformation studies play an important role in the drug discovery and development process. Usually data from drug metabolism is required before a new substance can advance towards the development stages of a new therapeutic agent. Data on metabolism is frequently used to optimize drug candidates, suggest more active compounds or support toxicology studies. The increased flux of new chemical entities into drug discovery has placed an increased need for fast and reliable information on the metabolism of these substances. Liquid chromatography coupled with mass spectrometry can meet demands for rapid drugs and metabolites analysis imposed by modern drug discovery strategies. This dissertation thesis presents an evidence...
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