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Molecular physiology of low-voltage-activated T-type channels in neuropathic pain
Pelant, Tomáš ; Weiss, Norbert (advisor) ; Fišer, Radovan (referee)
Low-voltage activated T-type channels contribute significantly to signal transmission in ascending pain pathway. Their electrophysiological and biochemical properties allow them to modulate neuronal excitability and neurotransmitter release. Alterations of electric currents associated with a number of neuronal disorders, including neuropathic pain and epilepsy, have been linked to this subtype of calcium channel, suggesting its prominent role in modulation of neuronal response to various noxious stimuli. Multiple diseases, such as diabetes, cancer or chronic nerve injury, are accompanied by painful neuropathic conditions. Specific inhibitors of T-type channels have been demonstrated to alleviate symptoms of neuropathic pain in mouse models, showing their potential for development of novel type of drugs possibly more effective than traditional analgesics, which exhibit minor effect in neuropathic pain treatment.
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The genetics of type II diabetes
Svobodová, Kristýna ; Ehler, Edvard (advisor) ; Pavlasová, Lenka (referee)
The bachelor thesis The genetics of type II diabetes is compound of several chapter. The major part is general characteristic of diabetes, diagnostics and pathogenesis. The thesis includes history of diabetes too. The last two chapters are focus on genetics. There are many knowledges which have been gained so far and objects future studies. Very interesting is chapter about genetics studies in variol continents, studies of ethnic groups. Key words Diabetes mellitus I., Diabetes mellitus II., disease, genetics, gen, locus, genome-wide association studies, heritability
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Healthy lifestyle of young population
Šturmová, Adéla ; Polišenský, Miroslav (advisor) ; Pilař, Tomáš (referee)
My thesis deals with healthy lifestyle of young population more specifically of children in the ate of 3 - 6 years. It is divided into two parts - theoretical and practical. The theoretical part clarifies the basic terms and concepts of a healthy lifestyle. This part mainly deals with balanced diet and nutrition, sleeping habits, stress, exercise and sports, drinking régime and last but not least the disease of civilization. There is also explanation of the term non-profit making organization which I have chosen for the further research. Second part of my thesis analyses the healthy lifestyle of children in kindergarten at Lipí in South Bohemia Region starting with information about the organization. I have also written the characteristic of kindergarten - sports facilities, funding, eating habits and meal plan. Additionally, Body Mass Index of the children has been measured. The outcomes of the analysis are evaluated at hte end of the thesis, which are completed with appropriate improvement recommendations.
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The influence of enzymes applied on processed sugar beet bulbs on the quality of saturated juice
Langrová, Petra ; Pulkrábek, Josef (advisor) ; Ilona, Ilona (referee)
The thesis focuses on the determination of dextran presence and its potential amount in sugar made semi-products. Dextran is a polysaccharide which is created on a sugar beet tuber due to inappropriate storing, because of low temperatures or wound of beet tissue, which is subsequently prone to infections caused by Leuconostoc mesenteroides microorganism. The infection results in creation of polysaccharides and other secondary products which have a negative influence on technological processing of beet. Levan and dextran create the highest amount of these polysaccharides in sugar beet. They significantly increase the viscosity of sugar juice. It is subsequently seen on crystallization of calcium carbonate during the second saturation and this causes the deterioration of filterability. In case of dextran or other polysaccharides presence other problems arise in the technological process of sugar production. For its elimination enzymatic hydrolysis is used with the aid of dextranase or alfa amylase. This element splits dextran polysaccharide into smaller oligosaccharids which are not caught in filtration device and therefore do not cause reduction in production capacity. Commercially accessible dextranase; however, is financially demanding so that there are researches trying to find more economical ways. This diploma thesis evaluates the presence of dextran in extracted juice by means of ICUMSA GS8-19 (year 2009). The method evaluates the presence of dextran in diffused, heavy and II. saturated juice. The research was focused on determination of alkalinity, pH, sedimentation and filtration coefficient, polarization, sugar content and purity. The aim of this thesis is to evaluate the correlation between recorded numbers and the application of the two enzymes which are used for removal of these problems. After completion of the experiment and evaluation of measured results in operating laboratory of sugar factory Tereos TTD Dobrovice, connection among laboratory measured data was not proved. Our recorded data did not prove reciprocal relation. The only proved connection was about number of rinsed filters (per day) after II. saturation and amount of used enzymes. The amount of enzymes influences how many times per day filters must be rinsed in order to get rid of deposit. In case of high amount of dextran, filters started to be clogged by impervious layer of molecules and in case that enzymatic way was not used for elimination of this saccharide, the only solution was frequent filters rinsing or reduction in working capacity connected to subsequent prolongation of processing campaign.
Further, we proved the efficiency of alfa amylase which was used during beet processing (after New Year). This enzyme had the same impact on elimination of polysaccharides and clearance of filters. It is to say that in following campaigns it is possible to substitute financially demanding enzyme for cheaper alfa amylase.
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Vliv různého zpracování půdy na výnosy a ekonomiku pěstování cukrovky
Dehner, David
The effect of different soil tillage on yields and economy growing of sugar beet grown after three forecrops (spring barley, winter wheat and silage maize) was studied in a long-term stationary field experiment conducted in the years 1993-2014 on loamy chernozem soil in sugar beet producing area. Four variants of soil tillage (1. variant -- plowing at 0.28 m, 2. variant - plowing at 0.22 m + loosening at 0.40 to 0.45 m, 3. variant - plowing at 0.28 m + freezable crop sowing and 4. variant - plowing to 0.22 m + freezable crop sowing) were evaluated. Observed results of impact of alternative soil tillage methods on the sugar beet grown after three forecrops on yields, sugar content and economy generally indicate suitability (from the point of production and economy) of the tillage technology with sowing of sugar beet into freezable crop. At least appropriate, in the given drier and warmer site conditions, was reflected deeper soil loosening to 0.40 - 0.45 m. The best forecrop for sugar beet was winter wheat, the least suitable forecrop was silage corn.
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Produkční a ekonomické hodnocení pěstování cukrovky při různých způsobech zpracování půdy
Jašková, Sabina
Sugar beet belongs to group of very importat crops in the agrotechnical and an economic terms. This dissertation deals with the evaluation of different variants of land processing and their influence on the amount of yield, sugar content and economy of sugar beet cultivation. The main experiment was conducted at the experimental field station in Žabčice. The evaluation was based on field experiment AGRO 2. As part of the crop rotation sugar beet was grown after winter wheat. Three variants of land processing were evaluated I. -- Classical with plowing, II. - Minimization technology (loosening), III. - Minimization technology (direct sowing). Three different methods of land processing were compared. Results achieved in years 2012 - 2014 were evaluated. Evaluation of the results showed that influence of land processing on yield of tubers was not statistically evidential. The highest avarage yield was found in the traditional processing with plowing. Influence of land processing was not statistically evidential even at the yield of rosette of leaves, but it was statistically evidential at sugar content. A certain tendency of increasing the sugar content at a lower land processing treatment was proven. Influence of the year was statistically evidential. Above standard was yield at the end of year 2014. After evaluation of the economic indicators of sugar beet, we can say that higher yields and the highest sales per 1 hectar were achieved, thanks to the classic land processing. Results of the study show that there is certain possibility of reducing depth and intensity of land processing for sugar beets. Of course the priority is to achieve good returns at lower costs. Minimal land processing is relatively fast expanding, and both ecological and economic advantages are connected with it.
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Faktory ovlivňující kvalitu cukrovky
Eignerová, Aneta
In a pursuance of a small-scale field experiment was to monitor the impact of extrarooted nutrition as one of the factors which influence the yield and technological quality of sugar beet. In the course of the vegetation was monitored for the growth and development of diabetes and the dynamics of change of its quality. On the basis of the observed results were evaluated by the following parameters - yield bulev, the yield shaw, sugar content, soluble ash, alpha-amino-nitrogen and MB factor. The highest yield of root was recorded after the application of fertilizers Yara Vita Bortrac (127 t/ha). At the time of harvest was the highest yield shaw determined after the application of the product Carbonbor On (39,6 t/ha). The highest sugar content was determined in the two years after the fertilization of the product Carbonbor. In the average of the two years has moved the content of soluble ash in the range of 0,68 - 0,75 %. The lowest was at the variants with the application of Yara Vita Brassitrel and highest in the variant, after the application of fertilizers Carbonbor K. The content of alpha-amino-nitrogen in different years differed, in the year 2012 amounted to the average of the value of 36,7 mg.100 g-1, and in 2013 was 26.3 mg.100 g-1. The highest value of the MB factor was determined for the variants with the application of fertilizers 3 Carbonbor K. Also there has been achieved a favorable value of 27. Most mature sugar beet has been harvested after the application of fertilizers Carbonbor.
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