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National Repository of Grey Literature 223 records found  beginprevious214 - 223  jump to record: Search took 0.03 seconds. 
Acyklické nukleosid fosfonáty a inhibice lidské telomerázy
 Hájek, Miroslav ; Matulová, Naděžda ; Votruba, Ivan ; Holý, Antonín ; Tloušťová, Eva
Diphosphates of acyclic nucleoside phosphonates were evaluated for their ability to inhibit human telomerase.
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Design a syntéza 5,6-disubstituovaných uracilových derivátů jako účinných inhibitorů thymidinfosforylasy
 Nencka, Radim ; Votruba, Ivan ; Hřebabecký, Hubert ; Tloušťová, Eva ; Horská, Květoslava ; Masojídková, Milena ; Holý, Antonín
We report on a series of novel 5,6-disubstituted uracils with significant inhibitory activity against human and Escherichia coli thymidine phosphorylases.
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Syntéza nových racemických konformačně omezených karbocyklických nukleosidů
 Šála, Michal ; Hřebabecký, Hubert ; Masojídková, Milena ; Holý, Antonín
Novel racemic conformationally locked nucleosides, derived from bicyclo[2.2.1]heptene or heptane, were prepared and tested for their biological activity.
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N6-methyl-AMP-hydrolasa aktivuje N6-substituované purinové ANPs
 Schinkmanová, Markéta ; Votruba, Ivan ; Holý, Antonín
Identification and characterization of a new enzyme, N6-methyl-AMP aminohydrolase, that is responsible for the conversion of N6-cyclopropyl-PMEDAP to biologically active PMEG.
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Acyklické bis-fosfonátové nukleosidy - nová analoga ANP
 Vrbovská, Silvie ; Holý, Antonín
As a part of the systematic SAR study in ANP series (many of ANP derivatives posses significant antiviral and cytostatic activity), we intended to study the behavior of ANP analogues bearing in the molecule two phosphonate residues.
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Tricyklické etheno analogy purinů odvozené od 2-amino-6-chlorpurinu
 Hořejší, Kateřina ; Pohl, Radek ; Holý, Antonín
A series of new linear and angular tricyclic etheno-bridged derivatives was synthesized from 2-amino-6-chloropurine and regioselectivity of the cyclization reaction was studied.
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Syntéza a vlastnosti chirálních acyklických nukleosid bisfosfonátů s otevřeným kruhem
 Doláková, Petra ; Masojídková, Milena ; Holý, Antonín
A new type of acyclic nucleoside phosphonates (ANP) is derived from 2,4-diamino-6-hydroxypyrimidine. These 6-[2-(phosphonomethoxy)ethoxy]pyrimidine derivatives significantly inhibit replication of retroviruses and herpesviruses in cell cultures. This novel subclass of pyrimidine ANPs can be considered as analogues of 2,6-diaminopurine with an open imidazole ring in the purine moiety.
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Syntéza N4-substituovaných derivátů 1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosinu (HPMPC, Cidofovir, Vistide)
 Chalupová, Šárka ; Holý, Antonín
1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, Cidofovir) has a broad activity spectrum against DNA viruses. As the systemic drug VireadTM is used for treatment of cytomegalovirus retinitis in AIDS patients. Based on this unique profile of HPMPC we have investigated the effect of the substitution of the amino function at the position 4 upon the antiviral activity.
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Aktuální pokroky v kapilární elektroforéze peptidů a bílkovin
 Kašička, Václav ; Koval, Dušan ; Šolínová, Veronika ; Sázelová, Petra
Recent developments in particular modes of high performance capillary electromigration methods will be presented with respect to their application to analysis, preparation and physicochemical characterization of peptides and proteins.
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Analýza, separace a studium vztahu mezi strukturou a pohyblivostí biopeptidů kapilární zónovou elektroforézou
 Šolínová, Veronika ; Kašička, Václav ; Koval, Dušan ; Hlaváček, Jan ; Barth, Tomislav
Capillary zone electrophoresis has been applied to the analysis, separation and physicochemical characterization of synthetic biopeptides such as insect oostatic peptides, enkephalins and dalargin.
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National Repository of Grey Literature : 223 records found   beginprevious214 - 223  jump to record:
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