Original title:
Synthesis of N4-substituted derivatives of (S)-1-[3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, Cidofovir, Vistide)
Translated title:
Syntéza N4-substituovaných derivátů 1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosinu (HPMPC, Cidofovir, Vistide)
Authors:
Chalupová, Šárka ; Holý, Antonín Document type: Papers Conference/Event: Chemistry of Nucleic Acid Components /13./, Špindlerův Mlýn (CZ), 2005-09-03 / 2005-09-09
Year:
2005
Language:
eng Abstract:
[eng][cze] 1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, Cidofovir) has a broad activity spectrum against DNA viruses. As the systemic drug VireadTM is used for treatment of cytomegalovirus retinitis in AIDS patients. Based on this unique profile of HPMPC we have investigated the effect of the substitution of the amino function at the position 4 upon the antiviral activity.1-[(S)-3-hydroxy-2-(phosphonomethoxy)propyl]cytosine (HPMPC, Cidofovir) je účinný vůči širokému spektru DNA virů. Jako VireadTM se používá pro léčbu cytomegalovirové retinitidy u pacientů s AIDS. Na základě účinků HPMPC byl zkoumán efekt substituce aminofunkce v poloze 4 cytosinové baze na protivirovou aktivitu.
Keywords:
ANP; antivirals; HPMPC Project no.: 1M0508 (CEP), 1UC1AIO62540-01, CEZ:AV0Z40550506 (CEP) Funding provider: GA MŠk, NIH Host item entry: Chemistry of Nucleic Acid Components, ISBN 80-86241-25-4
Institution: Institute of Organic Chemistry and Biochemistry AS ČR
(web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences. Original record: http://hdl.handle.net/11104/0111602