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Slit flow rheometer for magnetic and non-magnetic fluids
Železník, Tomáš ; Vimmr, Jan (referee) ; Roupec, Jakub (advisor)
In this thesis was designed, manufactured and tested the fourth evolution of a slit-flow rheometer with another necessary parts, eg. rheometer`s holder, drive frame and important jig tools. The rheometer is able to measure rheological properties of magnetic and non-magnetic fluids at very high shear rates, which commercial rheometers can not reach. It is designed for 200 bar pressure and maximum load 15 kN. The construction of the slit-flow rheometer with it`s holder and drive frame improves user friendliness, accelerates change of the fluid sample and expands research opportunities thanks to a big space for additional adjustments. It is possible to use different length of the slit and thanks to a changeable inserts it is possible to change parameters of the slit (roughness of the walls, wall material, thickness of the slit). A part of this thesis was focused on illation of necessary equations for planning calibration measurements. Aim of these measurements is to obtain minor pressure losses dependence on Reynolds number for specific slit.
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Preparation of chitin film
Debnáriková, Michaela ; Abdelrahman, Rasha (referee) ; Abdellatif, Abdelmohsan (advisor)
Predložená bakalárska práca sa zaoberá extrakciou, čistením, rozpúšťaním a prípravou filmu na báze chitín/ polyvinylalkoholu (PVA). Čistý chitín bol úplne charakterizovaný rôznymi metódami, ako je potenciometrická titrácia, FT-IR, TGA, XRD, SEM a pevná NMR. Rozpustnosť a čistota extrahovaného chitínu sa skúmala a hodnotila meraním obsahu proteínov, pomocou reológie a skúmaním času potrebného na rozpustenie. Filmy chitín / PVA boli pripravené použitím rôzneho pomeru roztoku chitínu a PVA. Merané a vyhodnotené boli morfológia povrchu, reologické a mechanické vlastnosti filmu.
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Influence of formulation factors on the characteristics of terbinafine loaded nanoparticles.
Barák, Vlastimil ; Šnejdrová, Eva (advisor) ; Dittrich, Milan (referee)
CHARLES UNIVERSITY FACULTY OF PHARMACY IN HRADEC KRÁLOVÉ DEPARTMENT OF PHARMACEUTICAL TECHNOLOGY Author: Vlastimil Barák Title of Diploma thesis The influence of formulation factors on the characteristics of terbinafine loaded nanoparticles Supervisor: PharmDr. Eva Šnejdrová, Ph.D. Consultant: Mgr. Juraj Martiška The diploma thesis is focused on biodegradable polymer nanoparticles loaded by terbinafine based on the copolymer of glycolic and lactic acid branched on polyacrylic acid. The nanoprecipitation method was employed, and the influence of formulation factors on nanoparticle characteristics was studied. The following formulation factors were the concentration of the polymer, the amount of terbinafine, and the concentration of surfactant. Nanoparticles of 120 nm to 300 nm were obtained depending on the preparation conditions. The nanoparticle polydispersity was in all cases from 0.080 to 0.230. The prepared nanoparticles were stable, as evidenced by zeta potential values above 38 mV. A positive zeta potential is desirable for dermal and mucosal adhesion in the topical and ocular application of nanoparticles with terbinafine. The amount of polymer used to form nanoparticles has the greatest effect on particle size. With increasing polyester concentration in the internal phase, the size of the...
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Differences in rheological properties of different wheat species
JORDÁKOVÁ, Lenka
In this bachelor thesis (Differences in rheological characters of different kinds of wheat) I compared four kinds of the most grown wheat all over the world which is food wheat. I compared as well as common wheat (Triticum aestivum L.) and hulled wheats which are primarily planted in ecological farming. Hulled wheats are einkorn (Triticum monococcum L.), emmer (Triticum dicoccum (Schrank) Schuebl) and spelt (Triticum spelta L.). In the end I compared 8 kinds of wheat. I was helped by the divice Mixolab II to record reological characters and bakery quality parameters of these wheat kinds. Researching was done twice with the same variety of samples, but it was planted in different years (2014 and 2015). During the measurement some differences of rated parameters appeared. System Profiler recorded results into graph and was able to compare important context and differences. According to these data a few quatations of known authors were confirmed. The best kind of wheat for bakery is common wheat, Spelt wheat haven´t got as good bakery quality as the first one, but it could be used in certain proportion in the mix of common wheat for bakery. At the same time there could be higher nutrition of products like biscuits, wafers and crackers. It would be good to decrease the intensity of planting when using einkorn or emmer wheat to get better quality in that way.
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Terbinafine-loaded biodegradable polymeric systems for topical administration
Pokorná, Tereza ; Šnejdrová, Eva (advisor) ; Dittrich, Milan (referee)
CHARLES UNIVERSITY FACULTY OF PHARMACY IN HRADEC KRÁLOVÉ DEPARTMENT OF PHARMACEUTICAL TECHNOLOGY Author: Tereza Pokorná Title of Diploma thesis Terbinafine-loaded biodegradable polymeric systems for topical administration Supervisor: PharmDr. Eva Šnejdrová, Ph.D. In the diploma thesis the released properties of solid dispersions with terbinafine, based on polyesters of D,L-lactic acid and glycol acid, branched with pentaerythritol and tripentaerythritol are studied. The theoretical part deals with solid dispersions, their classification and methods of preparation, methods of drug dissolution testing, properties, effect, use of terbinafine and preparations containing terbinafine. In the experimental part, solid dispersions were prepared by the melting method. The drug was incorporated into the polyester in the form of a hydrochloride or a base in a concentration of 10 % or 20 %. Some systems were plasticized with 30% triethyl citrate. Thin layers were formulated from solid dispersions, and drug dissolution tests were performed on phosphate buffer pH 7.4 at 37 řC. Assay of terbinafine released was performed spectrophotometrically at 223 nm and ultra-high performance liquid chromatography. Based on the results of this diploma thesis, it can be clearly stated that the suitable carrier of terbinafine...
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Terbinafine-loaded biodegradable polymeric systems for topical administration
Pokorná, Tereza ; Šnejdrová, Eva (advisor) ; Dittrich, Milan (referee)
CHARLES UNIVERSITY FACULTY OF PHARMACY IN HRADEC KRÁLOVÉ DEPARTMENT OF PHARMACEUTICAL TECHNOLOGY Author: Tereza Pokorná Title of Diploma thesis Terbinafine-loaded biodegradable polymeric systems for topical administration Supervisor: PharmDr. Eva Šnejdrová, Ph.D. In the diploma thesis the released properties of solid dispersions with terbinafine, based on polyesters of D,L-lactic acid and glycol acid, branched with pentaerythritol and tripentaerythritol are studied. The theoretical part deals with solid dispersions, their classification and methods of preparation, methods of drug dissolution testing, properties, effect, use of terbinafine and preparations containing terbinafine. In the experimental part, solid dispersions were prepared by the melting method. The drug was incorporated into the polyester in the form of a hydrochloride or a base in a concentration of 10 % or 20 %. Some systems were plasticized with 30% triethyl citrate. Thin layers were formulated from solid dispersions, and drug dissolution tests were performed on phosphate buffer pH 7.4 at 37 řC. Assay of terbinafine released was performed spectrophotometrically at 223 nm and ultra-high performance liquid chromatography. Based on the results of this diploma thesis, it can be clearly stated that the suitable carrier of terbinafine...
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Reologické vlastnosti kravského, kozího a ovčího mléka
Písaříková, Veronika
This thesis is focused on the rheological properties of cow, goat and sheep milk. These kinds of milk are described and compared in the first part. The thesis describes physical properties and technology of milk transport. Next part deals with legislation about milk in the European Union and in the Czech Republic. Special attention is given to the requirements of warehouse equipment and heat treatment of milk. Another part deals with analytical properties of milk (dry matter, protein, fat, lactose, acidity of the milk, electrical conductivity and density). In the last part are monitored rheological properties of these three types of milk. Selected samples are measured with shear stress depending on the strain rate. It is important because it helps us to determine what type of fluid is milk. Then, there is monitored dependence of the dynamic viscosity at the shear stress and effect of temperature on viscosity. These experiments demonstrated that milk belongs to liquids with Newtonian behavior. To evaluation the results was used Newton's law of viscosity and Ostwald de Waele model.
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Reologické vlastnosti žloutků slepičích vajec v průběhu skladování
Pavková, Lucie
The thesis deals with the influence of storage time on particular physical and rheolo-gical properties of a yolk of chicken eggs. Monitored eggs were stored at 6 °C for 8 weeks. The thesis describes the influence of storage time on physical characteristics of a whole egg, such as weight and shape index. As expected, the weight loss of chicken eggs was demonstrated during eight weeks storing. Egg yolk (colour, height, width, weight, index and density) was also described and evaluated in detail. According to our estimates, there are no significant changes in weight during yolk storing. But yolk index is distinctly decreased. During the final part of monitoring rheological properties were evaluated - apparent viscosity, time dependence of viscosity and dependence of shear stress on the shear rate (flow curves). The experiments have proved Newtonian behaviour of egg yolk throughout the storage. The storage time has also clear impact on flow properties of yolk. The results of each experiment were modelled using the power law (Ostwald-de Waele) model.
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Usage of of common reclaimed asphalt in asphalt mixtures
Přívara, Jakub ; Coufalíková, Iva (referee) ; Dašek, Ondřej (advisor)
The bachelor thesis is focused on adding of RAP (reclaimed asphalt pavement) to the wearing asphalt courses flexible pavements. Specifically it is SMA 11S asphalt mixture. The theoretical part describes issues of ecology and recycling. The practical part deals with bitumen recovery from SMA mixtures with different added ratios of RAP and assessment of basic empirical and functional tests on the bituminous binder. The verification of properities of modified bituminous binder used in this quality SMA mixtures is also introduced.
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Optimized manufacturing of aluminium castings by using lost wax technology
Talanda, Ivan ; Horenský, Jiří (referee) ; Horáček, Milan (advisor)
Aim of this diploma thesis is to choose new pattern wax for Fimes a.s. foundry. New wax should substitute old not fully satisfactory pattern wax which caused problems in technological process resulting in increased number of rejects. New pattern wax should eliminate current problems and help foundry with producing large, thin-walled, high-quality castings. Numbers of pattern waxes supplied by world’s leading wax manufacturers were subjected to laboratory tests and pilot study. This diploma thesis is part of project Alfa TA01010766: „Research and development of production technology large, thin and high quality castings of aluminium alloys “
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