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Postnatal Ontogenesis of the Skull of the Pond Slider Turtle (Trachemys scripta)
Čtrnáctová, Lenka ; Brejcha, Jindřich (advisor) ; Soukup, Vladimír (referee)
This thesis focuses on the descriptive analysis of skull morphology of the pond slider turtle (Trachemys scripta elegans). The general approach was an osteological preparation of the skulls and photographic documentation (following standardised procedures) of a larger sample of specimens. The collected data was used as a background for subsequent GMM analyses. Main hypotheses of this project were: 1) the skull of T. s. elegans is sexually dimorphic; 2) the skull of T. s. elegans constitutes of several independent modules. The objective of this thesis was therefore to describe the postnatal ontogenesis of the model taxon and to determine the developmental trends of its cranial structures. It was shown that the skull of T. s. elegans is sexually dimorphic in shape mainly due to differences in allometric growth. These differences probably reflect different nutritional requirements. The skull of T. s. elegans is formed out of four modules. These are: facial, central, basicranial, and possibly also zygomatic-pterygoideal modules.
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Mechanisms of maternal entrainment of the fetal circadian clock
Černá, Barbora ; Sumová, Alena (advisor) ; Balaštík, Martin (referee)
Our body is influenced by many cyclical changes in the environment, such as day and night or seasons. To predict these changes and react to them in time, the organism is equipped with inner clock, which rhythmically influences many physiological processes, such as sleep or metabolic rhythms. Disrupting our inner rhythms at molecular and behavioral levels contributes to many serious disorders. It is necessary that all mechanisms of the inner circadian clock are developed and set up properly. Circadian clocks are set up by the mother, who passes rhythmical information about day and night cycle on to her embryo. Though a great attention is devoted to revealing the nature of this synchronization between the mother and her pup, the mechanisms of this process have not been fully understood yet. The aim of this thesis is to contribute to actual understanding of this synchronization. Experiments, performed in this thesis, relate to studying the ability of maternal signals to synchronize embryos with the environment. Feeding and light regime of pregnant rats was manipulated and the effect of these changes on the neuronal activity within the suprachiasmatic nuclei of 19-day embryos was analyzed.
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Molecular basis of human congenital anomalies
Kovačičová, Denisa ; Šípek, Antonín (advisor) ; Rothová, Olga (referee)
This bachelor thesis deals with the topic of congenital anomalies. The sorting of the congenital anomalies is discussed in the first two chapters. The third chapter concerns the mutations of the short arm of chromosome 17. I have chosen to describe the Smith - Magenis syndrome, which is caused by the deletion of 17p11.2, and the Potocki - Lupski syndrome, which is its reciprocal duplication. The gene RAI1 is specified in this part. The other topic mentioned in this thesis are RASopathies. The research of this section deals with the Noonan syndrome and focuses on mutations in genes PTPN11, SOS1, RAF1, KRAS and NRAS. In the fifth chapter the issue of thalidomide, its history and the mechanisms of action discovered up to now are described. The critical period and the mechanisms of limb reduction defects related to the timing of exposure are also defined here. New methods and findings related to these topics are discussed in the end of this work. Key words: congenital anomalies, teratology, ontogenesis, Potocki - Lupski syndrome, Smith - Magenis syndrome, RASopathies, Noonan syndrome, thalidomide
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Development of callosal interhemispheric connection in laboratory rat
Matternová, Lucie ; Mareš, Pavel (advisor) ; Žiak, Jakub (referee)
Corpus callosum is the main commissure linking cortex of the right and left brain hemisphere. For the first time, the callosal axons are observed during E18, when they cross the midline. In PND 5, most axons reach the contralateral cortex, and at the end of the second postnatal week, the callosal projection neurons and axon terminals are located similarly to the adult animal. The interhemispheric response was first observed in the rat in PND 4 but myelination in PND 12, suggesting that the transcallosal response is not dependent on myelinization of callosal fibers. As the rat age increases, the wave duration of the TCR, latency peak and threshold decreases. As opposed to that, amplitude of the positive and negative wave increases with age. TCR may be affected by acute drug application or chronic exposure to various effects, such as hormones.
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Coordination abilities of students of second grade elementary school
Číhalová, Tereza ; Hájková, Jana (advisor) ; Jahodová, Gabriela (referee)
Name of thesis: Coordination abilities of students of second grade elementary school Author: Tereza Číhalová Tutor: PaedDr. Jana Hájková Department: department of physical education and sport Comparing the level of coordination abilities of children from sports classes and unsportsmanlike classes of second grade elementary school. Thesis in the theoretical part will deal with the motor abilities, the coordination abilities and ontogenesis. In the research part of the work will be focused on testing students' sports focused on athletics and unsportsmanlike classes of secondary school and post-processing and evaluation of results. Methodology: data collection, guided interview, comparison Conclusion: Finding a suitable test profile and preparing the necessary means for the measurement of target groups. Evaluation of results and processing them into charts and graphs. A group of athletes achieved better results than physically inactive students. Group of athletes achieved a slightly above-average overall results, the group of inactive students achieved a slightly below- average. Within a group, not a big difference between boys and girls. In tests, the best for both groups is Sprint according to a rhythm. In this test was the smallest difference in the results between the groups. The test, where was...
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Portfolio - a Tool of Assessment in Special Art Education
Formánková, Iveta ; Novotná, Magdalena (advisor) ; Čech, Viktor (referee)
This thesis deals with the collection, sorting and by reflecting artistic expressions of a particular child during the school year. The theoretical part contains information obtained from the study of literature concerning the concepts of art education, perception, sensitivity, imagination, creation, communication, portfolio assessment, children's drawing, ontogeny, psychiatric diagnosis, developmental disorders. The empirical part focused on the development of intellectual and social abilities in connection with the development of drawings, a boy with psychiatric diagnosis. The work is processed by the methods of qualitative research. It is a case study with subsequent analysis results of operations,ie his artistic expressions.
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Changes in opioid signalisation during the ontogenesis.
Hoľuková, Martina ; Hejnová, Lucie (advisor) ; Škrabalová, Jitka (referee)
Opioid receptors interact with opiate compounds, causing the inhibition of neuroexcitability. The activation of signaling pathway of opioid receptors plays crucial role in the treatment of chronic and cancer pain. Summary of the general knowledge about opioid receptors and about the development of tolerance is in the first part of this work. Next part of the thesis concerns on ontogenesis of opioid receptors and other components related to the opioid signaling pathways as age seems to have an immense influence on molecules within and related to the opioid signaling. Finally, last part of this work collects data about the influence of morphine during ontogenesis as morphine is one of the most used opiate compound used in clinical treatment. Key words Opioid receptor, signalization, ontogenesis, addiction, tolerance, morphine
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Circadian regulation of sleep during ontogenesis in humans
Grieblová, Adéla ; Sumová, Alena (advisor) ; Soták, Matúš (referee)
The circadian system has evolved as an adaptation to periodically changing conditions on Earth. In mammals, and therefore in humans, the circadian system consists of the central and perip- heral oscillators generating a circadian rhythm. One of the most significant process exhibiting circadian rhythm is the sleep-wake cycle. Sleep is regulated by cooperation of circadian and homeostatic process. There are changes in circadian regulation of sleep during ontogenesis in human. The changes mainly releate to chronotype, i.e., to the diurnal preferences of activity and sleep. In the first years of life, there is a typical morning chronotype. In the end of first decade of life, the circadian phase begins to delay and reaches its maximal eveningness during ado- lescence. In adulthood, the preference changes again toward morning chronotype and reaches extreme morningness in elderly. Changes in circadian regulation of sleep during ontogenesis depend not only on age, but also on sex. 1
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Modular and ontogenetic evolution of virtual organisms
Leibl, Marek ; Mráz, František (advisor) ; Šmíd, Jakub (referee)
Increase of computational power and development of new methods in artificial intelligence allow these days many real-world problems to be solved automatically by a~computer program without human interaction. This includes automatized design of walking robots in a~physical virtual environment that can eventually result in construction of real robots. This work compares two different approaches to evolve virtual robotic organisms: artificial ontogeny, where the organism first grows using an~artificial ontogenetic process, and more direct methods. Furthermore, it proposes a~novel approach to evolve virtual robotic organisms: Hypercube-based artificial ontogeny that is combination of artificial ontogeny and Hypercube-based neuroevolution of augmenting topologies (HyperNEAT). Powered by TCPDF (www.tcpdf.org)
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