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Stability of vesicular complexes against changes in their concentration
Velichová, Veronika ; Marková, Kateřina (referee) ; Mravec, Filip (advisor)
This bachelor thesis is focused on the stability of vesicular systems that consist of ion pair amphiphile. These catanionic vesicles were prepared from single-chained surfactants CTAB cetyltrimethylammonium bromide) and SDS (sodium dodecyl sulphate), which were stabilized by adding double-chained surfactant DODAC (dimethyldioctadecylammonium chloride) with 43 mol.% cholesterol. The aim of the thesis was to verify the stability of vesicular systems against changes in their concentration. For the measurement, a concentration series was prepared by diluting vesicles with deionized water. The stability was evaluated by dynamic (DLS) and electrophoretic (ELS) light scattering measurements at weekly intervals for four weeks. By DLS method were determined the average values of the size of vesicles and their changes during the measurement, the method ELS provided the information about changes of charge with different concentration in time. Samples with a higher concentration, i.e. no dilution till tenfold dilution of the vesicle solution, were marked as stable, higher values of average sizes and lower values of zeta potential were measured at solution with lower concentrations, according to which such diluted vesicles can be described as unstable. There were also visual observations made, but no visible aggregation in the solutions was observed. Furthermore, the aggregation behavior of the vesicles was observed by fluorescence spectroscopy using pyrene as fluorescent probe.
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Static analysis of the sports hall roof
Meissnerová, Sabina ; Hokeš, Filip (referee) ; Vlk, Zbyněk (advisor)
The final thesis deals with structural analysis of the roofing of the sports hall. Computational model was created in the computational software Dlubal RFEM 6.04 according to the provided documents. The loads were performed in accordance with valid standards and the structure was assessed for the ultimate and serviceability limit state. Manual assessment calculations were compared with the software. The final thesis deals with the manual calculation of internal forces on a curved beam from the self-weight of the structure and the stability of the structure is demonstrated first on a single-sided fixed beam and then on the created spatial model.
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Evaluation of Company Performance
Měcháčková, Tereza ; Večeřa, Michal (referee) ; Režňáková, Mária (advisor)
This Master´s thesis is focus on the evaluation of performance and financial health of the REDA corporation from 2006 to 2010. In the practical part of thesis is perfomed analysis of the company and financial analysis and a comparison of its results with three competing companies. The target of this master´s thesis is suggestions to improve and to conserve company performace.
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The Qualitative and Numerical Analysis of Nonlinear Delay Differential Equations
Dvořáková, Stanislava ; Baštinec, Jaromír (referee) ; Šremr,, Jiří (referee) ; Čermák, Jan (advisor)
Disertační práce formuluje asymptotické odhady řešení tzv. sublineárních a superlineárních diferenciálních rovnic se zpožděním. V těchto odhadech vystupuje řešení pomocných funkcionálních rovnic a nerovností. Dále práce pojednává o kvalitativních vlastnostech diferenčních rovnic se zpožděním, které vznikly diskretizací studovaných diferenciálních rovnic. Pozornost je věnována souvislostem asympotického chování řešení rovnic ve spojitém a diskrétním tvaru, a to v obecném i v konkrétních případech. Studována je rovněž stabilita numerické diskretizace vycházející z $\theta$-metody. Práce obsahuje několik příkladů ilustrujících dosažené výsledky.
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Design of audio power amplifier with Bluetooth connectivity
Bartoň, Jan ; Šotner, Roman (referee) ; Brančík, Lubomír (advisor)
This bachelor‘s thesis deals with the task of designing an audio amplifier, operating in class D, with a nominal output power of 2 x 80 W with Bluetooth connectivity, supplemented by an equalizer and a state display. A power supply and a user interface are designed as well. At first, research regarding audio amplifiers is made, followed by a more thorough description of class D operating principles. Afterwards the actual synthesis of the desired amplifier is presented, followed by the power supply design procedure. The correctness of the synthesis is later verified by simulations in PSpice and LTSpice. Theoretical design is then practically built, and its parameters are confronted with expected values by measurements.
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Prediction of Protein Stability upon Mutations Using Evolution Strategy
Pavlík, David ; Martínek, Tomáš (referee) ; Bendl, Jaroslav (advisor)
This master's thesis deals with the matter of predicting the effects of aminoacid substitutions on protein stability. The main aim is to design meta-classifier that combines the results of the selected prediction tools. An evolution strategy was used to find the best weights for each of the selected tools with the aim of achieving better prediction performance compared to that achieved by using these tools separately. Five different and obtainable prediction tools were selected and their prediction outputs were weighted. Two different approaches of evolution strategy are investigated and compared: evolution strategy with the 1/5-rule and evolution strategy with the type 2 of control parameters self-adaptation. Two independent datasets of mutations were created for training and evaluating the performance of designed meta-classifier. The performed experiments and obtained results suggest that the evolution strategy could be considered as a~beneficial approach for prediction of protein stability changes. However, the special attention must be paid to careful selection of tools for integration and compilation of training and testing datasets.
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VD Vlachovice - concrete gravity dam
Juriga, Jan ; Šulc, Jan (referee) ; Zachoval, Zbyněk (advisor)
As a part of this bachelor thesis an alternative design of the concrete gravity dam VD Vlachovice was made, to the already design of the earth-fill dam. The design of the outlet works, intake and spillway were also carried out as a part of the study. The introduction of the thesis includes a description of the site and an evaluation of local conditions. The next part deals with the stability of the dam and the load-bearing capacity of the subsoil. Furthermore, the design of the outlet works, intake and spillway were made. A part of the thesis also deals with the transformation of flood by the water reservoir. Finally, drawings and simplified 3D model of the dam were created. The documents necessary for the creation of the work were provided by company AQUATIS a.s. with the permission of Povodí Morava, s.p.
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Stability of humic complexes
Vlašicová, Silvie ; Smilek, Jiří (referee) ; Klučáková, Martina (advisor)
This bachelor thesis is focused on humic acids as an active ingredient of organic soil substance and their interaction with the selected drug, Ibuprofen. The aim of this work was to optimize the methods of drug determination in solutions containing humic acids. Subsequently, adsorption experiments were performer to provide information about the adsorption efficiency depending on the concentration of Ibuprofen. Desorption experiments were then used to determine the stability of humic substance complexes with Ibuprofen, or, more precisely, the proportion of the mobile and bound Ibuprofen fraction in the prepared complexes.
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Mathematical modeling of population problems in biology
Čampulová, Martina ; Opluštil, Zdeněk (referee) ; Čermák, Jan (advisor)
This bachelor´s thesis deals with the modeling of population problems in biology. The aim of this thesis is to mention some basic models describing dynamics of the evolution of one or two populations. Models mentioned in this thesis are described by first-order ordinary differential equations. Exploring the evolution of the population brings the main question - searching for singular points (and verifying their stability) of differential equations describing the evolution of the population. Therefore the thesis also deals with these problems.
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System analysis of braking truck - trailer combination
Haring, Andrej ; Kubjatko,, Tibor (referee) ; Řehák,, Miloslav (referee) ; Semela, Marek (advisor)
The dissertation deals with the issue of braking of articulated vehicles, especially articulated vehicles consisting of a tractor and a semi-trailer. This configuration was chosen with regard to the number of accidents and their consequences, and often also does not suit the technical condition of the tractor and semi-trailer, which is closely related to the safety of operation of these combinations. In the case of road accidents, the consequences are often very serious, whether it is personal injury or material damage. Investigating these accidents is a relatively demanding process, requiring a high degree of expertise as well as the necessary technical equipment. In contrast to these requirements, the availability of sources from which the necessary information can be drawn is relatively low. The available resources are mostly in a foreign language and are usually solutions to partial problems, not systemically comprehensive literature. Therefore, it is possible to say a "constant demand" for the available professional literature dealing with issues related to the solution of traffic accidents not only of combinations of vehicles, but of commercial vehicles as a whole. From the point of view of the importance, or topicality of needs arising from expert practice, the dissertation is thematically focused on braking of combinations of vehicles. There are several key reasons to focus on articulated vehicles. First of all, this is due to the specific character of the vehicle itself, which consists of two communication-linked brake systems. Other reasons are that the information contained in the dissertation, whether it is descriptive information, assessment of the technical condition of the systems, or the measurement results themselves, can be partially or even fully used for stand-alone towing vehicles or trailers. However, not all problems related to this issue can be solved within the dissertation. Therefore, in the dissertation, significant influences are selected, the solution of which, given the frequency and severity, the author considers essential. From the title of the dissertation it follows that this is a system analysis of the braking of combinations of vehicles. The system concept of solving a problem situation and selected problems are a guarantee that really essential parameters are selected within the content possibilities and scope of the dissertation and the system approach to their solution allows a "general" application in solving similar problems. The aim of the dissertation is a system analysis of the influence of selected parameters on the overall braking effect and stability of commercial vehicle combinations, analysis of input parameters on the decision logic of electronic brake system control unit, where procedures but also conclusions can be applied in similar cases with similar input parameters and decision criteria. Another partial goal is to develop a framework methodology for determining the technical condition of individual components of brake systems of commercial vehicles, which will be possible to apply especially in trucks, where electronically controlled systems are installed. Here, too, a systemic concept is applied, which will enable a wider use of this methodology.
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