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Spirulina Platensis effects on atherogenesis in mouse model of atherosclerosis
Žáková, Marie ; Nachtigal, Petr (advisor) ; Doleželová, Eva (referee)
Marie Žáková Spirulina platensis effects on atherogenesis in mouse model of atherosclerosis Diploma thesis Charles University in Prague, Faculty of Pharmacy in Hradec Králové Pharmacy Background: The aim of this diploma thesis was to evaluate possible antiatherogenic and antiinflammatory effects of Spirulina platensis in apoE-deficient mice. Methods: We used C57BL/6J male mice with deficiency of apolipoprotein E (apoE-/-) at the age of 3 months. The animals were divided into 2 groups (control and examined mice). Both groups were fed with cholesterol diet for 8 weeks. In Spirulina group, Spirulina platensis was added at dose of 20 mg/kg/day. The biochemical analysis was performed in order to discover the lipid spectrum of blood. There was also performed the histological staining with oil red in order to visualise the size of atherosklerotic leisons and to detect the lipids. The aim of the immunohistochemical analysis was to approve the amount of VCAM-1 expression. Results: Biochemical analysis did not demonstrate any significant decrease of total cholesterol expect from decreasing of LDL cholesterol. The presence of atherosclerotic lesions with lipids cumulation was illustrated by histological staining with oil red in both mice groups, the results of each group did not differ. In comparison with...
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Spread spectrum modulator
Lejsková, Alena ; Kováč, Michal (referee) ; Maršálek, Roman (advisor)
This thesis deals with a method of spectrum-spreading of the data signals transmitted in the radio channel. There exist three different ways of spreading application, they uses pseudorandom sequences and also orthogonal sequences. In these systems we can find various kinds of modulations, one of them (Quadrature Phase Shift Keying) is shown at the end of the thesis. Spectrum spreading orthogonal multiplex OFDM is based on this method. The thesis wants to present the principle of the spectrum spreading method and the description of systems, transmitters and receivers that are using this method.
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Bipyridine complexes of Ru(II) as SERS spectral probes of the mechanisms of surface -enhanced optical processes
Kokošková, Markéta ; Vlčková, Blanka (advisor) ; Šmejkal, Petr (referee)
SERS and SERRS (surface enhanced /resonance/ Raman scattering) spectra of a dicationic Ru (II) bis(2,2'-bipyridine)(4,4'-dicarboxy-2,2'-bipyridine) /Ru(bpy)2(dcbpy)/ complex in systems with aggregates of unmodified and/or chloride-modified Ag nanoparticles (NPs) were obtained and compared to those of dicationic Ru (II) tris(2,2'-bipyridine) /Ru(bpy)3 /. The splitting of several bands and the appearance of a new band at 1367 cm-1 observed solely in SERS and SERRS of Ru(bpy)2(dcbpy) in the system with unmodified Ag NP aggregates was attributed to chemisorption of the complex onto Ag NP surface via two carboxylate groups. SERS/SERRS excitation profiles obtained for the spectral bands and attributed to the Ru- dcbpy unit of the chemisorbed Ru(bpy)2(dcbpy)/ complex were found to maximize at 488 nm excitation, while those of the two Ru-bpy units peaked at 458 nm. Comparison of the profiles with the electronic absorption spectrum of free Ru(bpy)2(dcbpy) has revealed that chemisorption of the complex causes a red-shift of the Ru→dcbpy charge transfer transition band. The observed decrease of the energy of the Ru→dcbpy charge transfer is explained by an increase of the electron-withdrawing ability of the two COO- groups upon their chemisorption on AgNP surface. Concentration value of SERRS spectral...
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Asthetics and attitudes of the "new objectivity" in the "Zeitroman" of the late Weimar Republic
Jobová, Karolina ; Zbytovský, Štěpán (advisor) ; Weinberg, Manfred (referee)
- english The focal points of this thesis are the aesthetic principles and categories of the "new objectivity" and their development in the literary scientific discourse (1913-1932), as well as their establishment in the literary production as a reaction to the preceding period of expressionism. Using the four "new objective" novels, the goal is to demonstrate the artistic procedures, issues and typical characters of the "new objectivity" as a dominant literary movement of the '20's and the beginning of '30's. At the same time, a special attention is dedicated to the social climate, the impact of the Great Depression on the professional life and on unemployment as well as to the emancipation of women and picture of "new woman", the polarization of the political spectrum, the political and ideological positions of the typical characters, as well as the role of the media such as film and press and other aspects of the contemporary reality, all of which is reflected in the selected literary works. As a starting point of the stylistic and content analysis were selected "new objective" novels of the late period of the Weimar Republic, published after 1929. Since they all reflect the current events of the time, they can be classified as period novels ("Zeitromane"). The following novels were analysed:...
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Analysis of stochastic processes in electronic components
Vlčková, Irena ; Šebesta, Vladimír (referee) ; Zajaček, Jiří (advisor)
The Bachelor Thesis deals with the interference of electronic parts, using of non-destructive analysis for electronic interference in semi-conductive parts and measured samples. The thesis is divided into thematic areas: Interference types; Spectrum of random continuous signals, Spectrum calculation due to the method of periodogram and the method sub-banding coding and following FFT, Apparatus for interference measuring, Results of interference measuring. In the practical part 5 and 6, there are measuring results of chosen electronic parts, transport and interference characteristics and they are compared with theoretical presumptions.
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Measurement of cardiovascular parameters
Németh, Štefan ; Ronzhina, Marina (referee) ; Kolářová, Jana (advisor)
This thesis is about evaluating ECG signal with help of MATLAB. Grafic user iterface aplication was programmed to provide evaluation of source signal, its power spectrum, detects R-R intervals and determines ration between spectral components. Furthemore this thesis is considering practical use of HRV power evaluation in general medical practise.
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Current possibilities of data communication via the power network
Jedlička, Tomáš ; Mišurec, Jiří (referee) ; Mlýnek, Petr (advisor)
This thesis is focused on processing, summary information about PLC commnunication and analyzing present issue of data transfer via powerline grids. Teoretic and technical information about PLC communication, advantages, disadvantages, kinds of PLC communication depending on used frequency ranges and also about used modulation techniques are processed in the first part of the thesis. The second part of thesis is focused on analysis information about choice types of modems and companies, which are oriented on PLC technology. Measurements results of broadband PLC communication are evaluated in the third part of thesis with opportunity to extend and modification it. Laboratory measurement of narrowband PLC communication is processed and focused in this part on transmission speed and spectrum of signal. Results of measurement in company ModemTec are summarized in the end of thesis.
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A use of epidemiology data for a cancer risk assessment and the recautionary principle
Bencko, Vladimír
The traditional approaches and study designs in cancer epidemiology have not been very successful in identifying and evaluating adequately the potential risk and/or protective factors associated with the disease. The main reasons for the failure are often due to small study sample size, and inadequate exposure information. In this paper, issues and approaches relevant to these two challenges are discussed. Multicentre study is proposed as a way to increase study size and to mitigate criticism about meta-analysis of independent studies. A multicentre study of large cohort or case–control studies also offers an exciting opportunity to study the contribution of epigenetic events that may be associated with life-style and environmental risk factors for human health. Optimizing methods for exposure assessment and how to reduce exposure misclassification represent a difficult component in epidemiology studies. A potentially useful approach for improving exposure estimate is to rely on biomarkers of exposures. An example is provided to demonstrate how biomarkers of exposures could provide valuable information in addition to exposure measurements in traditional epidemiological studies. Finally, it is argued that risk assessment and the precautionary principle should not be viewed as conflicting paradigms but, rather, as a complementary approach for developing appropriate policies to address risks posed by exposure to carcinogens and a wide spectrum of other health hazards.
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Examination of vegetative system in hereditary neuropathy
Jílková, Daniela ; Horáček, Ondřej (advisor) ; Kobesová, Alena (referee)
Aim: The aim of this thesis "Examination of vegetative system in hereditary neuropathy" is to consider the level of physical fitness, physical actvity level and quality of autonomic function in patients with hereditary neuropathy Charcot Marie Tooth and an assessment of interactions of these parameters, especially with regard to possible influence by the presence of autonomic neuropathy and with regard to neurological symptoms. Background: Although vegetative neuropathy was mentioned in the first publication about CMT, it is not widely discussed topic as part of it. Methods: Seventeen probands underwent spiroergometry, heart rate variability test, six minute walk test, rating by the CMT Neuropathy Score and Overall neuropathy disability scale and completing the IPAQ questionnaire. Results: We found symptoms of autonomic neuropathy in group of patients with CMT, especially high-frequency part of heart rate variability spectrum has a particularly significant decrease. Patients with autonomic neuropathy have shown a low fitness and functional capacity, tendency to obesity and hypertension. The observed correlation of autonomic neuropathy and neurological impairment was very weak. Conclusions: We find a neuropathy of the autonomic nervous system in patiens with hereditary motor and sensitive neuropathy...
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Design of elongated right angle milling head for horizontal boring machine
Svoboda, Ondřej ; Tůma, Jiří (referee) ; Holub, Michal (advisor)
This thesis deals with design of right-angled elongated milling head for horizontal boring machine of FERMAT production. The thesis includes a detailed research of milling heads, a description of the head´s basic components and certain commercially available head´s comparison. Design part is describe components description and the design. Calculations are focused on determinating of forces generated during machining, setting of loading spectrum and the power load calculating individual gears during machining. In the next part is calculation of the reactions in the spindle bearings included, the equivalent load and durability of spindle bearings, spindle deformation and spindle bearings optimum distance. The thesis also includes spindle strength calculation, horizontal and vertical shafts analysis, gears design with helical teeth and gear strength. The thesis describes the design of extended milling head and particular design nodes which is supplemented by the 3D model. In this thesis is also included a drawing of assembly and components.
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