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Business plan: Event agency targeting at international customer base
Bukáček, Ondřej ; Hartman, Ladislav (advisor) ; Desenský, Lukáš (referee)
The goal of this master´s thesis is to create a complex business plan for event agency situated in Prague but targeting not only locals. The business plan was written for internal use of its author to assess the profitability and feasibility of the business idea. The author used several reference literature resources. The actual business plan is to be found in the practical part. The whole structure follows the frame and information researched in the theoretical chapter of the thesis. The main chapters of the plan include the description of market opportunity, marketing strategy, financial plan and analyses of the market, competition and risks.
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Mortgage loans in the Czech republic
Königová, Jaroslava ; Kislingerová, Eva (advisor) ; Smrčka, Luboš (referee)
The thesis summarizes the situation on mortgage market in the Czech republic from the 90th of the 20th century till present time, reasons for the mortgage boom. It informs about the state support of housing (incentives, state programmes), state residential conception.It defines kinds of morgage and gives its characteristics, informes about the phases of mortgage arrangement, scoring method for client evaluation and regulative standards for bank risk management. It shows housing and mortgage in statistics.There are mentioned the actual results of financial competition and influence of American mortgage crisis on the Czech mortgage market.In conclusion,it states the trends in the Czech mortgage market.
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The motor and cognitive consequences of inborn cerebellar degeneration and some possibilities how to influence it
Křížková, Alena ; Vožeh, František (advisor) ; Pokorný, Jaroslav (referee) ; Mareš, Jan (referee)
The motor and cognitive consequences of inborn cerebellar degeneration and some possibilities how to influence it The cerebellum is traditionally considered to be a coordinator of movements and equilibrium and a regulator of muscular tone. Participation of the cerebellum on the motor learning has been discovered later. Besides that, there is increasing experimental and clinical evidence supporting the idea of an important role of the cerebellum in common cognitive functions. Increasing number of experimental works - especially those on animals - demonstrate an effect of the the cerebellum on the memory and different types of learning. A suitable model to study the cerebellar degeneration are Lurcher mutant mice. During their lives, there is a progressive loss of Purkinje cells followed by a loss of granular cells and inferior oliva neurons. We concentrated on the following problems in this work: - development of motor learning and topical motor skills during the first month of life - positive and negative changes in NO synthesis and subsequent effect on discriminative learning - effect of administration of MK-801(non-competitive antagonist of NMDA receptors) on discriminative learning of Lurcher mutants and wild mice derived from two strains (C3H and C57B1/7). Lurcher mutants and wild mice were put in motor...
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The testing of celiac disease in connection with osteoporosis
SLADKÁ, Romana
My Bachelor´s thesis deals with the examination of celiac disease in connection to osteoporosis. The aim of the thesis was to specify the level of antidotes against tissue transglutaminase in the class IgA and IgG in the serum with osteoporosis diagnosed patients, to interpret, based on the results of the study, possible link between osteoporosis and celiac disease as well as to compare the outcome with scientific data. I focused on the present knowledge of osteoporosis and celiac disease in the first part. As for celiac disease, I described its history and characteristics. I also paid attention to diagnostics of celiac disease with the assistance of laboratory serological tests ELISA. I mentioned the free-gluten diet treatment after that. As regards osteoporosis, I described its history, symptoms, forms, perils and complications which the disease causes. I conducted the methodical part of my work in the biochemical haematological laboratory Stafila where I work, with its seat in České Budějovice. As for measurements, I took them in the department of microbiology, where immunologic tests are also taken. I carried out the screening of celiac disease from serum, namely the determination of antidotes against tissue transglutaminase in the class IgA and IgG, with the aid of ELISA - a sandwich method. I took measurements with 58 osteoporosis diagnosed patients. I obtained the sera thanks to the supervisor of my thesis Mrs. Marie Ládová, who is at the head of an osteological outpatient department in České Budějovice. I stated the serological markers of celiac disease with the assistance of enzymatic immunoanalysis conducted on automatic analyzer Nexgen Four, which was provided by the firm Test-Line. I describe the analyzer, its specification, checking and calibration of the gadget together with determination checks in this part of the thesis. Additionally, there is described the principle of the method ELISA- sandwich, which is non-competitive enzymatic immunoanalysis. At the end of the section there is depicted the methodical procedure of my work, the preparation of working solutions and checks, the preparation and dilution of samples for analysis and working procedure for semiquantitative interpretation with positivity index and for quantitative interpretation U/ml. I continued with my own measurements. while respecting standard operations procedures of the laboratory Stafila, a limited liability company. The results of my measurements are processed in the third part of the thesis. The acquired results are given in a table: quantitative interpretation of the antidote against tTg IgA and IgG (U/ml) level in the sera of the osteoporosis diagnosed patients. Then I presented a graph interpreting the proportional relation of the antidote against tTg IgA and IgG levels in the sera of the osteoporosis diagnosed patients. There are included calibration graphs for tissue transglutaminase IgA and IgG and tables of the obtained data of checks for the methods in the results. 3 out of the 58 examined samples of osteoporotic patients were positive, they had the level of antibodies higher than 22 U/ml. One of the samples had marginal figures, which means it had the antidotes against tTg IgA an IgG between 18 and 22 U/ml. Positive results were found with patients born in 1976 and 1978. A patient born in 1962 appeared to have a marginal result. The acquired antidote figures against tissue transglutaminase in the class IgA and IgG are presented proportionally in the graph 1. 3 out of the 58 measured samples were positive, which represents 5%, and 1 sample was marginal, which is 2%. My analysis is based on the availability of the examined material and the potential of our laboratory. Celiac disease is an illness which was not paid much attention to in the past. Hypothesis about the link between osteoporosis and celiac disease has been proved.
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Business plan for waste recycation
Vavřina, Radek ; Kovář, František (advisor)
Item of the bachelor work is a business plan. It includes external analysys, competition, market and marketng analysys. History of the company and management. There are budget, financial and logistic plans, costing of products, cash-flow plans and financial analysys with financial ratio indikators for next 5 years.
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Trh s elektřinou v České Republice (teorie a praxe)
Pavlátka, Pavel ; Schwarz, Jiří (advisor) ; Brychta, Pavel (referee)
Liberalization and privatization of the electricity industry is one of the most important processes in the few last years. Even when the electricity market is fully open, substantial barriers to competition often remain. These barriers are refusal of access to the market, the lack of capacity in interconnectors and long-term contracts. The process of liberalization has shown that a third-party access to the network is a critical and important factor in ensuring a real and effective liberalization of the market. The process of liberalization has also supported new ways and forms of energy trading including financial contracts instead of purely physical contracts for the delivery of electricity. It is a question if the benefits of liberalization of the electricity industry compared with a regulated private monopoly or public monopoly were profitable. Someone could argue that the liberalization of electricity tends to bring benefit to monopoly structures and increase prices of electricity in industry. This work tries to present the pros and cons of liberalization in the electricity industry while taking in consideration the best means of making the liberatization as much profitable and useful as possible.
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Imperfect competition on the market of television broadcasters SR and CR
Bodnár, Maroš ; Jemelka, Ivan (advisor) ; Sunega, Petr (referee)
Rise of imperfect competition, more precisely its oligopoly form, has became very wide spreed. In certain extent we can say that this is a result of government regulation in different areas of national economy. Aim of this work was to analyze and compare television stations market in SR and CR and evaluate those interactions among channels in their respective economies, which lead to rise in the concrete situation on the market. Also to show some oportunietis, that might be exploited by new TV companies entering this industry. Most importent in this sector will by liberalization, which will lead to better form of competetiv advantage and will bring more costumers to this market. It partly explains horizont of digital broadcasting, which implementing currently runs in all Europe contries.
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Significantion of sumoylation for infection by selected viruses replicated in the cell nucleus
Sejpková, Marie ; Forstová, Jitka (advisor) ; Frydrýšková, Klára (referee)
This work introduces association between viruses and host cell with respect to sumoylation process. The main aim is referring to influence of this modification both on virus replication strategy and cell cycle. Sumoylation is essential process for cell regulation interfering with general regulation pathways including those performed by e.g. p53 or PML bodies and also epigenetic changes of chromatin. For viruses, sumoylation means stabilization of viral proteins and better timing each phase of viral cycle through viral protein. One point of view is competition of cell and virus for SUMO machinery. Viruses take advantage of sumoylation for inhibition antiviral defense of cells, regulation cell cycle mainly in apoptosis induction and in general for more successful infection. There are cumulating evidence of new proteins and phenomena connected with sumoylation mechanisms as well as viruses exploiting sumoylation for their benefit. Utilization and abuse of sumoylation by viruses point to future possibilities of cell manipulation and virus ability to intervene to this still relatively poorly understood type of cell regulation.
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Coal-fired power plants: cheap electricity vs. clean environment
Krydl, Ondřej ; Loužek, Marek (advisor) ; Kozák, Jan (referee)
The aim of this thesis is to analyze the importance of coal-fired power plants on the market of electric energy, with emphasis on aspects that fundamentally affect their production. Coal-fired power plants belongs nowadays among socially unpopular source of electricity. In recent decades intensively growing interest groups that support state intervention and regulation of the energy sector. This is essentially a massive promotion of renewable energy sources at the expense of fossil fuel plants. Analysis of individual power sources shows that despite the current restrictive measures imposed on power plants burning fossil fuels, and especially coal-fired power plants, electricity produced from coal resources is still competitive, despite some drawbacks has many positive qualities. Coal-fired power plants produce higher amounts of greenhouse gases and other pollutants than other types of power plants. On the other hand, they are able to provide a stable supply of electricity to transmission network, and thus partially offset the high volatility of electricity supply from renewable energy sources. The price of electricity from coal-fired power plants could be considered as relatively low in comparison with other energy sources. The analysis shows that in terms of practical economic policy is not economically justified to reduce the proportion of coal-fired power plants in the total production of electricity.
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