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Mechanisms of activation and modulation of the TRPV1 receptor: relationship between structure and function
Touška, Filip ; Vlachová, Viktorie (advisor) ; Teisinger, Jan (referee)
Vanilloid Receptor Subtype 1 - TRPV1 - is an important member of the TRP ion channel family. The physiological role of this ion channel is to integrate the nociceptive signals from the peripheral nervous system. TRPV1 participates in the detection of noxious stimuli on the primary afferent sensory neurons: of the chemical stimuli, such as capsaicin, resiniferatoxin, inflammatory mediators, endogenous vanilloids, and of the low pH (<6.5), and of the noxious heat stimuli (>43řC). Apart from the high expression on the dorsal root ganglion neurons and trigeminal ganglions, the functional expression of this receptor has been also found in the central nervous system, where its role remains elusive, however. Structural-functional studies which have been carried out since the receptor was first cloned, that is 13 years ago, have revealed several specific characteristics. Nonetheless, a number of questions remain to be answered, particularly those concerning cellular mechanisms and regulation of TRPV1's activation, modulation, and its complex function in the nervous system. The aim of this diploma thesis was to characterize, using electrophysiological and fluorescence techniques, the activation and desensitization kinetics of recombinant TRPV1 receptor in relation to the dynamic changes of intracellular calcium....
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Seqence circuit for radioamateur transciever
Dvořák, Pavel ; Šnajdr, Václav (referee) ; Lukeš, Zbyněk (advisor)
In this paper we will deal involving short-wave radio station and its control by the sequencer. Mostly it will be a time delay of the PA and the antenna switching relay in the transmitter (TX) to receiver (RX) side. Time delays will be controlled programmatically using ATmega 16 microprocessor, which will form part of the main control sequencer. The delay will set the total time of keying in messages, when we take into account the loss due to delayed first symbol. Keying will be done from several sources, among the main sources will be ordered from keying the radio, telegraph keys, and PC. The transmission signal is used amplitude modulation (SSB) in the CB zone.
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Approaches to computer cognition of musical recordings
Kadlec, Jan ; Majerech, Vladan (advisor) ; Obdržálek, David (referee)
In our study we deal with various stages of human cognition of real-life musical signals, create their models and discuss their implementation. The rst part compares time-frequency representations and their factorization into sinusoids and background noise. We combine various approaches to coupling sinusoids into trajectories. Next we examine methods for the estimation of note parameters from trajectories and methods for musical instrument classi cation. The nal part focuses on global music-theoretical features of recordings such as tempo, melodic phrases, chord accompaniment or key.
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ECG monitor in LabVIEW
Pavlišta, Libor ; Kolář, Radim (referee) ; Harabiš, Vratislav (advisor)
The main purpose of this work is to get know about ECG signal, its genesis and relationship between mechanical and electrical part of the heart. Furthermore about the detailed disassembly of parts, for example of QRS complex, the determination of faulty statuses, the calculation of heartbeat frequence. We will take a look into the patient's monitors. We will get know about the measuring of ECG signal and how to treat the input signal to eliminate the undesirable components of signal, for example unwanted network noise - so-called network brum. We will study the concept of simple monitoring system with th draft of necessary filter in LabView program. We will construct alarms for some cardiac abnormalities, such as premature heart contractions. We will calculate heart rate. We will retrieve of data from an external source and we will prepare the appropriate graphical user interface.
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Application versatile module LabJack\hindex{TM} in education of physics
PŘIBYL, Vojtěch
Theme of this thesis is using of universal module LabJack U3-HVTM as support for physics lessons. This thesis describes the universal module LabJack U3-HVTM and evaluation method of measured value on the computer screen using software eSimLab. To all physical tasks is described path of signal with measured string from developed sensor until evaluation of signal in the computer. In the thesis is specifically described a function of developed sensors of physical quantities, there are subscribed diagrams including PCB and parts list. The thesis is including designed physical tasks for monitoring of atmospheric pressure, temperature, wind direction, sunshine duration and the role of measurement of the signal on the optical transmitter using the developed sensors and universal module LabJack U3-HVTM.
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Human Capital and Education in Czech Republic
Houžvičková, Nela ; Chytil, Zdeněk (advisor) ; Brožová, Dagmar (referee)
This bachelor work deals with human capital and education. The first part of my work is focused on the theory of human capital, which comes from the work of the economist Gary S. Becker. In this part influences on formation of human capital are described, in more detail the theme of investments to human capital, types of investments, their rate of return and the risk rate are specified. Next this part is concerned with a connection between education and economic growth and with a theory of signals. The second part is focused on an education system in the Czech Republic, its comparison with other world education systems and last but not least on its financing.
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The molecular mechanism of CSL protein participation in oxidative stress response in Schizosaccharomyces pombe
Daněk, Petr ; Převorovský, Martin (advisor) ; Sipiczki, Matthias (referee)
Redox homeostasis maintenance is important for proper organism and cell function, for while relatively low amount of reactive oxygen (and nitrogen) species contributes to the fine tuning of signal transduction, excessive concentration of ROS (oxidative stress) has demonstrably harmful effects and is tightly connected to many pathological states. Cells therefore evolved broad palette of antioxidant mechanisms that express striking level of conservation among different species. Large, intricate stress response signaling networks have been already described; nonetheless, novel molecules employed in stress-related signaling are still being discovered. Several studies recently suggested transcription factors CSL, proteins essential for regulation of metazoan development as effectors of Notch signaling, are also involved in response to oxidative stress. The fission yeast Schizosaccharomyces pombe, well established model of response to various stresses, comprises two paralogs of CSL proteins - Cbf11 and Cbf12. We have found cells depleted of cbf11 are highly resistant to hydrogen peroxide. This resistance appears to be caused by upregulation of important stress responsive genes including ctt1, gst2, pyp2, and atf1. Cbf11 is therefore negative regulator of these genes, which suppresses their expression...
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Program for design of CATV
Sedláček, Jan ; Hála, Ondřej (referee) ; Říčný, Václav (advisor)
The main task of this master’s thesis is to create an interactive computer programme for the design of small and medium television cable circuits. The first part of this document describes main conceptions of a modification and a distribution of television signals. There are also introduced basic topologies of small and medium sized distribution networks, some passive and active elements in the circuit including their usage. There is also described an algorithm for calculation of circuit’s values. The second part contains a detailed description of created programme with all of its functions. A part of this document is made by a sample calculation of the four variants of circuit and its comparison with computer calculation. In suplement are included selected parts of source code.
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Logistics management of inventory
Jankovská, Marie ; Štůsek, Jaromír (advisor) ; Ladislav , Ladislav (referee)
This diploma thesis deals with the issue of a logistic stock management in the company STOLFIG s.r.o. (Ltd.) that focuses mainly on the construction and production of metal products. The theoretical part deals with the basic terminology such as logistics, its management and targets. Nevertheless, most of the theoretical part is focused on the stock, specifically on its characteristics, structuring, management and also risks and costs connected with it.
At the beginning of the practical part, the company is introduced with the focus on the stock characteristics and its management system. The next part analyses the present stock management, particularly the analysis of costs, turnover and liquidity, and an ABC analysis. Attention is also paid to the signal level of the stock, the process of selecting suppliers, an unnecessary stock and a warehousing system. Every part is not only analysed but it is also evaluated whether the present situation is satisfactory or not.
The third part is based on the given analysis and it contains specific recommendations for improvement, namely in the field of the minimum stock determination, evaluation criteria for supplier selection, management with material with no turnover, and also recommendation for changes within the warehouse. The final part is a clear summary of the whole thesis.
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