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The in vitro effects of selected fenolic substances on isolated rat vessels
Rajtmajerová, Iveta ; Pourová, Jana (advisor) ; Hrdina, Radomír (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Iveta Rajtmajerová Supervisor: PharmDr. Jana Pourová, Ph.D. Title of diploma thesis: The in vitro effects of selected fenolic substances on isolated rat vessels Silymarin flavonolignans are endowed with various aspects. Recently their hepatoprotective effect has been discussed widely as well as their positive influence on the cardiovascular system. This diploma thesis is concerned with the vasodilatory effects of silybin-A, silybin-B, silybin-A + B and isosilybin-A on rat aorta. The aim of this study was to test the vasodilatory effect of selected substances. The dependence of aortic relaxation on the increasing concentration of tested substances was measured. Isolated Wistar breed rat aorta was used. DRC curves were created and EC50 values were assessed from the obtained values of vessel tension. The results were evaluated subsequently. The vasodilator potential of silybin-A and isosilybin-A is comparable; hence the position of the substituents may be irrelevant in having any impact on relaxation of the vessels. Different vasodilatory effects of silybin-A and silybin-B have been observed thus, the relaxation could be stereoselective. The testing of the equimolar mixture of silybin-A and...
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Aspects of registration of vessels in maritime law
Mládek, Matěj ; Ondřej, Jan (advisor) ; Balaš, Vladimír (referee)
Název diplomové práce: Aspekty registrace plavidel v mezinárodním právu (oblast mezinárodního práva mořského a registrace námořních plavidel) (Aspects of the registration of vessels in the International Law) Abstrakt: Along with fishing, navigation is the oldest use of the sea, and remains one of the most important. Ships are the most important means of transporting goods on such routes: ninety-five per cent, by weight, of all international trade is seaborne. On the military side is it same important battle field. While almost all costal States and some landlocked (right now without Czech Republic) ones have a merchant navy of some description, one of the remarkable features of the international shipping industry is the degree to which ships are concentrated under the flags of relatively few States. This does not necessarily indicate a similar distribution of ownership. We are talking about "flags of convenience" and it is one of the topics of this thesis. This thesis deals transformation from customary international law to current codified regulation of the registration of vessels. The ascription of nationality to ships is one of the most important means by which public order is maintained at sea. As well as indicating what rights a ship enjoys and to what obligations it is subjects, the nationality of a...
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Quantitative vessel parameters of broadleaves as a tool for reconstruction of physical geographical processes
Tumajer, Jan
Trees adjust wood anatomical structure to environmental conditions, predisposing time series of quantitative wood anatomical parameters to be valuable source of palaeoenvironmental information. In this doctoral project we analysed the response of vessel parameters of i) floodplain Quercus robur to groundwater level fluctuation, hydroclimate variability and extreme events (droughts and floods), and of ii) Betula pendula to mechanical damage caused by various disturbances. Although climatic signal as well as pointer years stored in tree-ring width chronologies of Quercus robur largely differ between sites, quantitative vessel parameters contain spatially- homogenous positive signal of previous year summer temperature and current year winter/early spring temperature. The only between-site difference in wood anatomical chronologies is negative effect of moisture on vessel size in floodplain, which does not occur in not-flooded lowland sites. We suggest that while tree productivity benefits from high water availability, the wood anatomical structure of Quercus robur is constrained by high soil water saturation in floodplain zone. In addition, the response of tree-ring widths to moisture availability is not uniform inside single stand, but subgroups of trees with completely opposite response coexist...
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The in vitro effects of selected fenolic substances on isolated rat vessels
Rajtmajerová, Iveta ; Pourová, Jana (advisor) ; Hrdina, Radomír (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Iveta Rajtmajerová Supervisor: PharmDr. Jana Pourová, Ph.D. Title of diploma thesis: The in vitro effects of selected fenolic substances on isolated rat vessels Silymarin flavonolignans are endowed with various aspects. Recently their hepatoprotective effect has been discussed widely as well as their positive influence on the cardiovascular system. This diploma thesis is concerned with the vasodilatory effects of silybin-A, silybin-B, silybin-A + B and isosilybin-A on rat aorta. The aim of this study was to test the vasodilatory effect of selected substances. The dependence of aortic relaxation on the increasing concentration of tested substances was measured. Isolated Wistar breed rat aorta was used. DRC curves were created and EC50 values were assessed from the obtained values of vessel tension. The results were evaluated subsequently. The vasodilator potential of silybin-A and isosilybin-A is comparable; hence the position of the substituents may be irrelevant in having any impact on relaxation of the vessels. Different vasodilatory effects of silybin-A and silybin-B have been observed thus, the relaxation could be stereoselective. The testing of the equimolar mixture of silybin-A and...
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The in vitro effects of selected fenolic substances on isolated rat vessels
Rajtmajerová, Iveta ; Pourová, Jana (advisor) ; Hrdina, Radomír (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology & Toxicology Student: Iveta Rajtmajerová Supervisor: PharmDr. Jana Pourová, Ph.D. Title of diploma thesis: The in vitro effects of selected fenolic substances on isolated rat vessels Silymarin flavonolignans are endowed with various aspects. Recently their hepatoprotective effect has been discussed widely as well as their positive influence on the cardiovascular system. This diploma thesis is concerned with the vasodilatory effects of silybin-A, silybin-B, silybin-A + B and isosilybin-A on rat aorta. The aim of this study was to test the vasodilatory effect of selected substances. The dependence of aortic relaxation on the increasing concentration of tested substances was measured. Isolated Wistar breed rat aorta was used. DRC curves were created and EC50 values were assessed from the obtained values of vessel tension. The results were evaluated subsequently. The vasodilator potential of silybin-A and isosilybin-A is comparable; hence the position of the substituents may be irrelevant in having any impact on relaxation of the vessels. Different vasodilatory effects of silybin-A and silybin-B have been observed thus, the relaxation could be stereoselective. The testing of the equimolar mixture of silybin-A and...
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Quantitative vessel parameters of broadleaves as a tool for reconstruction of physical geographical processes
Tumajer, Jan
Trees adjust wood anatomical structure to environmental conditions, predisposing time series of quantitative wood anatomical parameters to be valuable source of palaeoenvironmental information. In this doctoral project we analysed the response of vessel parameters of i) floodplain Quercus robur to groundwater level fluctuation, hydroclimate variability and extreme events (droughts and floods), and of ii) Betula pendula to mechanical damage caused by various disturbances. Although climatic signal as well as pointer years stored in tree-ring width chronologies of Quercus robur largely differ between sites, quantitative vessel parameters contain spatially- homogenous positive signal of previous year summer temperature and current year winter/early spring temperature. The only between-site difference in wood anatomical chronologies is negative effect of moisture on vessel size in floodplain, which does not occur in not-flooded lowland sites. We suggest that while tree productivity benefits from high water availability, the wood anatomical structure of Quercus robur is constrained by high soil water saturation in floodplain zone. In addition, the response of tree-ring widths to moisture availability is not uniform inside single stand, but subgroups of trees with completely opposite response coexist...
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Quantitative vessel parameters of broadleaves as a tool for reconstruction of physical geographical processes
Tumajer, Jan ; Treml, Václav (advisor) ; Kolář, Tomáš (referee) ; van der Maaten, Ernst (referee)
Trees adjust wood anatomical structure to environmental conditions, predisposing time series of quantitative wood anatomical parameters to be valuable source of palaeoenvironmental information. In this doctoral project we analysed the response of vessel parameters of i) floodplain Quercus robur to groundwater level fluctuation, hydroclimate variability and extreme events (droughts and floods), and of ii) Betula pendula to mechanical damage caused by various disturbances. Although climatic signal as well as pointer years stored in tree-ring width chronologies of Quercus robur largely differ between sites, quantitative vessel parameters contain spatially- homogenous positive signal of previous year summer temperature and current year winter/early spring temperature. The only between-site difference in wood anatomical chronologies is negative effect of moisture on vessel size in floodplain, which does not occur in not-flooded lowland sites. We suggest that while tree productivity benefits from high water availability, the wood anatomical structure of Quercus robur is constrained by high soil water saturation in floodplain zone. In addition, the response of tree-ring widths to moisture availability is not uniform inside single stand, but subgroups of trees with completely opposite response coexist...
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Aspects of registration of vessels in maritime law
Mládek, Matěj ; Ondřej, Jan (advisor) ; Balaš, Vladimír (referee)
Název diplomové práce: Aspekty registrace plavidel v mezinárodním právu (oblast mezinárodního práva mořského a registrace námořních plavidel) (Aspects of the registration of vessels in the International Law) Abstrakt: Along with fishing, navigation is the oldest use of the sea, and remains one of the most important. Ships are the most important means of transporting goods on such routes: ninety-five per cent, by weight, of all international trade is seaborne. On the military side is it same important battle field. While almost all costal States and some landlocked (right now without Czech Republic) ones have a merchant navy of some description, one of the remarkable features of the international shipping industry is the degree to which ships are concentrated under the flags of relatively few States. This does not necessarily indicate a similar distribution of ownership. We are talking about "flags of convenience" and it is one of the topics of this thesis. This thesis deals transformation from customary international law to current codified regulation of the registration of vessels. The ascription of nationality to ships is one of the most important means by which public order is maintained at sea. As well as indicating what rights a ship enjoys and to what obligations it is subjects, the nationality of a...
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Design of Sailing Boat
Křížová, Barbora ; Řezníček, Svatopluk (referee) ; Křenek, Ladislav (advisor)
The topic of this master‘s thesis is design and analysis of a sailing boat in accordance with ergonomic and technological requirements. The goal is to create a sailing boat, which will be modern, visually interesting and which and which will take future development of both design and technology into account.
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Hydrodynamic mixing of water-ask mixture in vessel
Holub, Přemysl ; Franc, Zdeněk (referee) ; Habán, Vladimír (advisor)
Master´s thesis Hydrodynamic mixing of water-ash mixture in vessel is interested in describing fluid and solid particles flow in a vessel. The mixing was conducted in cylindrical vessel by a radial nozzle. The goal of the thesis is to describe flow field and places where the most of the particles are descending according to position, depth, flow rate and nozzle orientation in the vessel. An experiment was conducted in order to investigate and document 8 different positions and orientation of the nozzle. Significant changes in flow fields and mixing time were observed. A mathematical model of the vessel with the nozzle was created in Fluent program. Places with the lowest velocities according to the model were in good agreement with places where the most of the solid particles were descending.
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