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Petrol station and lighting tower for races of GT cars
Nakládal, Tomáš ; Dočkal, Aleš (referee) ; Mazůrek, Ivan (advisor)
The aim of this diploma work is an engineering design of technical set of equipment for endurance racing according with FIA regulations. Equipment of pit box should assure: refueling, lighting place of pit box and distribution of compressed air. CAD model of box equipment is designed in SolidWorks 2007 software. Construction is verified by the help of finite element method (FEM) in ANSYS WORKBENCH software. Main emphasis is attached to functionality, variability and low prize of this solution.
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Apartment house, Brno - Židenice
Šmíd, Václav ; Peterka, Tomáš (referee) ; Müller, Jan (advisor)
Within the frame of my master's thesis I processed a project documentation for a construction of an apartment house in Brno – Židenice. The building is unattached and has 7 floors. On the ground floor there are four individual garages, cellar cubicles and a utility room. There are apartments on all other floors. On the highest floor, there is situated a singular apartment with outdoor terrace and vegetation area. The building is founded on strips made of reinforced concrete, vertical load-bearing structure is made of cermic blocks, floor structure is made of hollow core slabs and staircase is also made of prefabricated elements. The house is insulated with contact thermal insulation made of mineral wool. During the process of creating the projet, I followed all the requirements of actual regulations and legal enactments, to provide sufficient mechanical endurance and stability, health safety of the inner space as well as safety of the natural environment.
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Constructive - Technological Project of Medical Center in Vizovice
Špalková, Martina ; Lukášková, Jana (referee) ; Mohapl, Martin (advisor)
The diploma thesis is based on a project of medical centre in Vizovice. The medical centre is designed as a three-floor building with a receding top floor. Building foundations are designed from foundation pads and strips from reinforced concrete, the load-bearing masonry is designed from hollow clay blocks ZELUS, a reinforced concrete ceiling is designed as a bracing element. The medical centre is roofed by a flat roof with a PVC covering. This thesis deals with the budget and time plan of the whole construction, transport accessibility of the building, building maintenance instructions and maintenance costs for 25 years, daylighting of room number 1.32, an engineering report of construction site equipment and its drawing, a design of lifting mechanism of the site equipment, a plan for transport of concrete and concreting the floor slabs. The thesis is mainly focused on roofing of the medical centre, technological regulation for the roofing and reinforced concrete floor slabs is elaborated, as well as a control and test plan for the floor slabs from the reinforced concrete and for the roof PVC foil.
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Professional diseases of locomotory and nervous system as the fundamental problem of current occupational medicine
Kotrík, Ján ; Hrnčíř, Evžen (advisor)
Professional diseases musculoskeletal system and the nervous extremities of long-term excessive unilateral preťažovania (the NPP) working in the Czech Republic were included in the list of occupational diseases in 1975. This is a diverse group of diseases neurologickej, ortopedické or reumatologickej nature which jednotiacim element should be the same Profesionální primary causal noxious substance - the excessive burden of unilateral (NPP). Will exhibit different symptoms and do not arise the same mechanism. Diseases of the NPP are as a consequence disbalancie between biological resistance of tissues of the body and physical claims, to which no specific work places an. Occur are thus to a greater or lesser extent in many professions, but also are known also as a general disease without a confirmed connection their work. Unilateral excessive and long-term zaťažovanie musculoskeletal and nervous the limbs, or even beyond their biological resistance, excessive pressure, tension, or the torzia some tissues, or a high number of the same repetitive motion carried lokálnymi muscle groups, under conditions when the raids is not fully recovery, mikrotraumatizácii lead to a gradual vznikajúcimi manifestations of damage to tendons and their úponov, knuckles and nervous. According to the Annex to the Regulation of the...
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Podíl subtypů P2 receptorů na modulaci glutamatergního přenosu v mozkové kůře
Honzová, Lenka ; Herink, Josef (advisor) ; Hrdina, Radomír (referee)
Glutamate is the major excitatory neurotransmitter in the central nervous system, and there is emerging evidence that its release is subject to presynaptic regulation by P2 receptors. Activation of P2X receptors elicited glutamate release from terminal of dorsal horn neurons of spinal cord and hippocampus whereas activation of P2Y receptors has been shown to inhibit glutamate release in the hippocampus. Glial cells express several subtypes of P2Y receptors and there is growing evidence that these cells are active elements at synapses, they release ATP upon activation of glutamate receptors and participate in the regulation of glutamatergic transmission. The aim of the present study was to investigate the role of P2Y receptors in the regulation of glutamatergic transmission in rat brain cortex; whether uptake of glutamate by glial cells is influenced by P2Y receptor-activation and to identify the subtypes of P2Y receptors involved. Primary cultures of cortical astrocytes obtained from brain hemispheres of newborn rats were used as a model to study the influence of P2Y receptors on the uptake of glutamate. We clarified the role of several P2Y agonists and we identified the subtypes of P2Y receptor involved in the regulation of synaptic concentration of glutamate which may provide the knowledge for...
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Synthesis of 5-hydroxy-3-phenyl-2H-1,3-benzoxazine-2,4(3H)-diones and their sulfur
Růžková, Barbora ; Macháček, Miloš (advisor) ; Palát, Karel (referee)
Synthesis of 5-hydroxy-3-phenyl-2H-1,3-benzoxazine-2,4(3H)-diones and their sulfur analogues Barbora Růžková The thesis is concerned with the preparation of 5-hydroxy-3-phenyl-2H-1,3-benzoxazine- 2,4(3H)-diones, 5-hydroxy-3-phenyl-4-thioxo-2H-1,3-benzoxazin-2-ones and 5-hydroxy-3- phenyl-2H-1,3-benzoxazine-2,4(3H)-dithiones, i.e. cyclic analogues of 2,6-di- hydroxybenzanilides. The starting 2,6-dihydroxybenzanilides were synthesized by the microwave-assisted reaction of 2,6-dihydroxybenzooic acid with aniline (unsubstituted or para-substituted by chlorine, methyl, butyl or methoxy groups) in the presence of phosphorus trichloride. Their treatment with ethyl-chloroformate afforded 5-hydroxy-3-phenyl-2H-1,3-benzoxazine-2,4(3H)- diones in 77 - 94 % yields. 5-Hydroxy-3-phenyl-4-thioxo-2H-1,3-benzoxazin-2-ones and 5- hydroxy-3-phenyl-2H-1,3-benzoxazine-2,4(3H)-dithiones were obtained by thionation using Lawesson's reagent in 31 - 42 and 24 - 33 % yields, respectively. All the compounds were characterized by infrared and NMR spectroscopy and by elemental analysis. No substance exerted either antimycotic activity (against Candida albicans, C. tropicalis, C. krusei, C. glabrata, Trichosporon asahii, Trichophyton mentagrophytes, Aspergillus fumigates, and Absidia corymbifera) or antimycobacterial activity...
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Risk elements contamination in Kutná Hora region and possibilities of its usage in paleoenvironmental research
Horák, Jan ; Hejcman, Michal (advisor) ; Jaromír, Jaromír (referee)
The dissertation focuses on topic of using risk elements contamination as a stratigraphic marker in palaeoenvironmental research. The contamination is not studied only as itself, but is viewed as a way to analyse and interpret the sedimentary record of historical events. The contamination carries the information about its original place, its original activity, about development of the landscape.
The Kutná Hora region (central Bohemia; 49°57'0.170"N, 15°15'59.877"E) is a region of important historic mining and smelting activity. The mining started in 13th century and lasted until half of 16th century. Then only sporadic attempts of renewal were made. Spatially limited mining was renewed in second half of the 20th century. Therefore, it is highly probable to find here the contaminants in the role of stratigraphic markers. In the research were used mainly As, Be, Cd, Co, Cr, Cu, Hg, Pb, V and Zn as these are the most analysed in contamination studies performed in the region.
The aims of the dissertation were to answer these questions:
To characterize the contamination
- Are some risk elements typical for the contamination originating from the mining and smelting?
- If so, is their environmental (spatial, sedimentary) manifestation diversified?
- Is possible diversity spatially related to particular landscape features or areas?
- Is possible diversity connected to particular activities?
To use the answers in analysis of particular sites
- Is it possible to use the risk elements contamination as stratigraphic marker in fluvial sediments?
- How is the interpretation of particular site influenced by the whole context of regional contamination?
The core of the research is the metaanalysis of contamination data coming from region (the data obtained by our research and also from other studies). The results have brought not only basic characteristics of contamination, mainly concentrations. The crucial result was the structure of studied elemental complex. Only As, Cd, Cu, Pb and Zn are connected to contamination originating in mining and smelting. Other elements - their concentrations and spatial distributions - are uninfluenced by mining and smelting activities. More, the information about connection of As and Cd to mining and Cu, Pb and Zn to smelting was revealed. Both groups recorded with different spatial distributions. Also comparison of results by different approaches has shown that some statistical processing (clr-transformation) of such dataset was much better for interpretation than analyses of only concentrations values.
We studied also the area of confluence of two rivers - Klejnárka (main river draining contaminated region), which is tributary to Labe (Elbe) river. The contamination is still recognizable here, but the diversity between contamination elements is not. The confluence of rivers strongly dilutes the contaminated material. The concentrations decrease. Also here clr-transformation of data enabled to analyse structures of contaminants spatial distribution unrecognizable by concentrations values.
We performed also two vertical profiles analyses. It was shown, that it is highly risky to interpret data of such origin without the complex information about regional contamination context. It was revealed by contextual interpretation of data from one of the profiles, that there is a mixing of geochemical data coming from different statistical populations. The contamination works there as only one of the factors influencing sedimentary record. The site is therefore suitable for statistical testing of two populations mixing, outliers` detection and the like.
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The Influence of Soil Amendments on the Uptake of Toxic Elements and Nutrients by Plants
Vondráčková, Stanislava ; Tlustoš, Pavel (advisor) ; Radim, Radim (referee)
Plant cultivation in soils heavily contaminated by risk elements is a challenging issue due to phytotoxic effects that restrict plant growth. Liming and phosphate additives application reduce the mobility of some risk elements in contaminated soils and can be a suitable measure for contaminated soils but can also affect availability of nutrients for plants. Therefore, it is necessary to test response of tolerant plants (trees and herbs) on soils heavily contaminated by risk elements and look for the most suitable combination of soil additives and tolerant plants.
Experimental part of PhD thesis was divided into the incubation experiments and the vegetation pot experiments. The incubation experiments: The efficiency of liming and phosphate additives at three application rates was tested for micro- and toxic elements immobilisation in weakly acid and alkaline soils heavily contaminated by As, Cd, Pb, and Zn within period of 42 days. The vegetation pot experiments: The two tolerant plants Salix × smithiana Willd. (three-year experiment) and Rumex obtusifolius L. (one-year experiment) were planted in the same contaminated soils as in the incubation experiments. Both soils were untreated and treated with two doses of lime and dolomite (S. smithiana) or treated with lime and superphosphate (R. obtusifolius). For both plants, we evaluated the initial plant growth, plant mortality, biomass production or content of macro-, micro- and toxic elements in the biomass. We evaluated also the content of organic acids in the biomass of R. obtusifolius.
Higher immobilisation effects on acid-extractable Cd, Zn, Pb, and Mn was observed for fast soluble additives (lime, superphosphate) compare to slow soluble additives (dolomite, rock phosphate) only in weakly acid soil. Lime application irrespective of dose with foliar Fe application and planting willows in the second year after the application of lime seemed to be the most suitable measure for increasing biomass production and decreasing toxic elements, especially Cd and Zn, without decreasing the macro- and micronutrients in the aboveground organs of willows in weakly acid soil. Seedlings of R. obtusifolius are sensitive to high availability of Ca, Cd, Pb, and Zn in soil. Biomass production was negatively related to the mobility of micro- and toxic elements. Elevated transport of micro- and toxic elements from belowground organs into leaves was recorded in both lime-treated soils and in superphosphate-treated alkaline soil as a result of sufficient amount of Ca available from soil solution as well as from superphosphate that can probably modify distribution of micro- and toxic elements in R. obtusifolius as a representative of oxalate plants. Rumex obtusifolius is an As-, Cd-, Pb-, and Zn-excluder and is sensitive to high availability of micro- and toxic elements in the soil. Soil chemical properties affect the distribution of essential elements within the plant greatly. In alkaline soil, R. obtusifolius is an Al-hyperaccumulator with the highest concentrations of oxalate in leaves, of malate in stems, and of citrate in belowground organs. These organic acids form strong complexes with Al that can play a key role in internal Al tolerance.
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Corporate Governance
Kupčiková, Eva ; Pirožek, Petr (advisor) ; Král, Pavel (referee)
The diploma thesis deals with issues of administration and control of a company, so-called corporate governance. It deals with relationships and links between the owners and management that need to be regulated because the ownership is separated from the management and control. The aim of this work is a thorough examination of the current state of corporate governance at a particular company. The primary object of the examination is the ownership and organizational structure, individual elements, their relationships and competencies and subsequent evaluation of the effectiveness and efficiency of the applied system.
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New building of sports centre, Jemnice
Procházka, Pavel ; Čtvrtníčková, Kateřina (referee) ; Kolář, Radim (advisor)
An elaborated project documentation for a construction realisation of a sports centre in Jemnice is the core of this diploma thesis. During the elaboration of this proposal a special attention was given to meeting of all active norms and regulations, and also meeting of all requirements of an investor. The main requirement was a multifunctionality of the whole building which consists of a restaurant, bigger and smaller gyms, a fitness room and utility space for a fluent working of all the building. The proposed sport centre is a two-storey building where the main part, sports hall, measures 24 x 50 meters. It is suggested to use a skeletal system from prefabricated concrete elements together with a roof from wooden trusses for this building.
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