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Case Study of Physiotherapy Treatment of Patient after liver transplantation and colon resection
Pavlíček, Jan ; Vláčilová, Ivana (advisor) ; Nováková, Tereza (referee)
v Abstract Author: Jan Pavlíček Title: A case report of physiotherapeutic treatment provided to a patient following liver transplantation and colon resection Objectives: This bachelor thesis aimed to introduce theoretical information concerning issues with a liver transplant, and large intestine resection and elaborate on a case report of a patient that underwent the above-mentioned procedures. Methods: This bachelor's thesis is divided into two parts. The liver and large intestine's anatomy, physiology, and pathophysiology are discussed in the first general section. Following chapters are devoted to the main treatment options for advanced liver diseases, i.e. liver transplantation, and indication and possibilities of colon resection. Physiotherapeutic approaches used in the mentioned procedures and further options of treatment for these patients are mentioned in the later chapters. The second specialized part describes a case report of a patient post-liver transplantation and large intestine resection. Included is a report of therapies that the patient underwent as part of ongoing professional practice in IKEM in January and the beginning of February 2023. Results: The patient was not showing any signs of improvement after the therapeutic interventions. This was due to many factors including the general...
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Case Study of Physiotherapy Treatment of an Adult Patient after a liver transplant
Mahenová, Barbora ; Stupková, Michaela (advisor) ; Nováková, Tereza (referee)
Author: Barbora Mahenová Supervisor: Mgr. Michaela Stupková Title: Case report of physiotherapeutic care of an adult patient after liver transplantation Objectives: The main aim of this bachelor thesis is to summarize the theoretical information about liver transplantation and to prepare a detailed case report of an adult patient who underwent this surgery. Methods: The theoretical part summarizes the knowledge about liver transplantation, specifically about indications and contraindications for transplantation, waiting list, organ donation, complications of the procedure, immunosuppressive therapy and quality of life of patients after liver transplantation. Furthermore, the theoretical part covers the general principles of rehabilitation after transplantation and physiotherapeutic examination and therapeutic methods and procedures. The special part includes a detailed case study of physiotherapeutic care of a patient who has undergone liver transplantation. The case report also includes a description of the therapies that took place as part of a continuous professional practice at the Institute of Clinical and Experimental Medicine in Prague between January and February 2023. Results: The patient achieved an improvement in fitness and a significant reduction in pain in the surgical wound area over...
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The ethical aspects of handeling the bodies of deceased
VIKTOROVÁ, Nikola
The diploma thesis deals with the ethical aspects we can indentify when dealing with bodies of the deceased. It describes how the deceased body is treated with respect to human dignity or human rights and also shows how the deceased's body was treated in the past and how funeral ceremonies and burials of the human remains looked like. It also deals with the evaluation of the approach to dead body these days. The procedures after death are described as well as the forms of funeral, funeral services or cemeteries. The thesis marginally deals with the funeral customs of selected ethnic minorities living in our territory. A special area is dedicated to the treatment of deceased children, the possibilities of their burial and farewell to their parents. Ethical issues in the field of organ donation are presented here also in the end.
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A Case study of Physiotherapy on a Patient after Liver Transplantation
Hettiaratchi, Lukas ; Kučerová, Ilona (advisor) ; Sárazová, Daniela (referee)
Title: A Case Study of Physiotherapy on a Patient after Liver Transplantation Author: Lukas Hettiaratchi Objectives: The purpose of this work is to review in-depth theory concerning liver transplantations along with the rehabilitation process that entails it. Moreover, create an adequate case study of a patient after liver transplantation. Methods: This work is divided into two sections, the theoretical part, and the special part. The first part consists of information gathered through scientific literature, it includes the anatomy, physiology and pathophysiology of the liver. Furthermore, it dives into the specifics of liver transplantations and recommended physiotherapy. The second section exhibits a complete case study of early post-operative physiotherapy on a patient after liver transplantation. The case study was conducted during a month of clinical practice at Institut Klinické a Experimentální Medicíny (IKEM) from the 10/01/2022 - 04/02/2022. Results: The patient significantly progressed throughout the physiotherapeutic care. Their overall physical condition improved, that led to the ability of independent verticalization and gait. Keywords: Liver, transplantation, alcohol liver disease, portal hypertension, ascites, physiotherapy
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Significance of the major histocompatibility complex for hemopoietic stem cell transplantation
Graman, Vojtěch ; Slavčev, Antonij (advisor) ; Dobeš, Jan (referee)
The genes of the major histocompatibility complex are located on the short arm of chromosome 6 and encode surface glycoproteins (HLA glycoproteins), which ensure the presentation of self and foreign peptides on the cell surface. These glycoproteins are subsequently recognized by T-lymphocytes and by other cells of the immune system. When the HLA-peptide complex is recognized as foreign, T-lymphocytes and other components of the immune system are activated, and the foreign cell is destroyed. Therefore, in hematopoietic stem cell transplantation (HSCT), HLA incompatibility between donor and recipient causes a strong immune response against the transplanted cells, and is therefore a major criterion in selecting suitable stem cell donors. This work briefly summarizes the current knowledge about the structure and function of HLA class I and class II antigens. The work focuses on HLA typing techniques to help understand the HLA system, which include serological typing methods, as well as modern molecular typing methods based on PCR and next-generation sequencing, and their relevance for HSCT. We also focus on HSCT processes and preparatory therapy, but the main emphasis is on the importance of HLA incompatibilities between stem cell recipients and donors and their effect on HSCT outcome.
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The Human Organ Transplantation Act - moral and ethical problems of its application
Novotná, Kateřina ; Císařová, Dagmar (advisor) ; Sovová, Olga (referee)
The Human Organ Transplantation Act - moral and ethical problems of its application This thesis deals with issues related to the applications of the Human Organ Transplantation Act. It is focused on the assessment of existing legislation regarding transplantation, the identification of problematical areas of transplantation law and the possibility of their correction. The thesis is divided into several parts. At the beginning it deals with the history and development of transplant medicine. It also contains a description of the current legislation and a brief summary of an international regulation. The main focus of the thesis is to analyze the deficiencies in Czech legislation and to emphasize the interdisciplinary nature of the transplant law. Finally, it analyzes the forthcoming amendment to The Human Organ Transplantation Act prepared by the Ministry of Health. The Human Organ Transplantation Act is a modern legislation respecting international commitments of the Czech Republic. Nature of the transplant legislation is given by its fundamental aspects the principle of presumed consent in connection with legally provided guarantee to respect disagreement expressed in accordance with law, the preference of a deceased donor prior to a living one, the principle of fairness in the allocation of...
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The role of IL-17 in kidney transplantation
Menšíková, Markéta ; Stříž, Ilja (advisor) ; Krulová, Magdaléna (referee)
The role of IL-17 in kidney transplantation - abstract Naive CD4+ T-lymphocytes (Thp) can develop into Th17 line in the presence of TGF- and IL-6. Th17 cells are characterized by expression of Ror- t and by production of interleukin-17 (IL-17). It is secreted as a glycoprotein homodimer. Binding to IL-17 receptor (IL-17R), which is present in all cell types, stimulates the production of proinflammatory cytokines and chemokines. The ratio of Th17: Treg in the graft showing signs of rejection is higher than in the graft without rejection. The presence of IL-17 in a culture of proximal tubular epithelial cells (PTEC) stimulates the production of IL-6, IL-8, MCP-1 and C3 complement component. Simultaneous action of IL-17 and CD40L synergistically increases the production of IL-6, IL-8 and RANTES. Signaling from the receptor on the surface of PTEC associated with its increased expression is effected via the src kinase and MAP kinase, and probably leads to the transcription factor NF- B. In rat models of transplantation, the IL-17 appears in allografts on the second day after surgery, the level rises until the fifth day, then decreases and disappears before the death of the animal. IL-17 is not detectable in isografts and negative controls. It appears before the IFN- , which had been considered a trigger of...
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Immunomodulatory properties of mesenchymal stem cells - use in therapy
Pavlíková, Michaela ; Krulová, Magdaléna (advisor) ; Stříž, Ilja (referee)
Mesenchymal stem cells (MSC) are extensively studied mainly due to their feasible clinical application. Therapeutic potential of MSC consists not only of the ability to differentiate into mesenchymal cells, ectodermal and endodermal cell lines, but primarily in their immunomodulatory functions. Due to their effect on immune cells, MSC promote the shift of the inflammatory immune response to antiinflammatory. The ability to suppress inflammation, together with their differentiation potential and antiapoptotic potential on the surrounding cells makes MSC a promising tool for treating serious diseases. This work discusses the effect of MSC on the individual cells of the immune system. It focuses on the description of the effect of MSC in four model cases. These are an experimental autoimmune encephalomyelitis, myocardial infarction, diabetes mellitus and skin graft transplantation. The knowledge of the mechanisms of the interactions between MSC and the cells of the immune system, together with the understanding the effect of specific conditions on MSC is essential for their use in clinical therapy. Keywords: mesenchymal stem cells, immunomodulation, autoimmune diseases, transplantation
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Transplantation and Organ Donation in the Awareness of the Non-professional Public
Sládková, Andrea ; Votroubková, Michaela (advisor) ; Vachková, Eva (referee)
This bachelor thesis offers a complete overview of the tissue of organ donation and transplantation. The theoretical part contains information on the history of transplantation of vital organs. It describes the opportunities and risks of modern transplantology - the multicultural and ethical aspect. It covers activities of transplant centre and current legislation with emphasis on the criteria determination of brain death. Finally, it outlines the care of the potential donor and his/her loved ones. Empirical part is focused on the exploration level of awareness of the general public in the possibilities of organ donation and transplantation, including attitudes on the topic. Key wards: Transplantation, organ, donor, brain death
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Formation of anti-hCMV immunity
Písková, Lucie ; Žůrková, Kamila (advisor) ; Fraiberk, Martin (referee)
The human cytomegalovirus (HCMV) is an ancient double-stranded DNA virus that belongs to subfamily β Herpesvirinae and is ubiquitous in human population. Like other herpesviruses infections, the HCMV primary infection leads to a lifelong latency and the virus reactivates from latency periodically through the whole life. The transmission of this virus depends on direct contact among people. The primary HCMV infection is usually asymptomatic in immunocompetent individuals but the reactivated virus is a major cause of diseases in immunocompromised individuals including AIDS patients and allo-graft transplant recipients. This work represents a report about HCMV and its coexistence with the host immune system. The thesis also contains information about complications caused by HCMV in patients who underwent solid-organ or hematopoietic stem cell transplantation.
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