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The Study of Order Processing in the Business Company
Tomková, Veronika ; Baštýřová, Hana (referee) ; Milichovský, František (advisor)
The bachelor's thesis deals with the study of order processing in the business company BMKco. s.r.o., which sells fasteners as a wholesaler. This work is divided into three parts, where the first part of the work is focused on a theoretical basis. The second part is analytical, where I analyze the current state of the contract, which is based on the materials provided, interviews with specific employees, and research of individual processes of the company with the help of research methods. The last part is the proposals, which contain suggestions for eliminating risks in the company.
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The Study of Order Processing in the Business Company
Tomková, Veronika ; Baštýřová, Hana (referee) ; Milichovský, František (advisor)
The bachelor's thesis deals with the study of order processing in the business company BMKco. s.r.o., which sells fasteners as a wholesaler. This work is divided into three parts, where the first part of the work is focused on a theoretical basis. The second part is analytical, where I analyze the current state of the contract, which is based on the materials provided, interviews with specific employees, and research of individual processes of the company with the help of research methods. The last part is the proposals, which contain suggestions for eliminating risks in the company.
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Molecular mechanisms of tamoxifen resistance in breast cancer
Tomková, Veronika ; Truksa, Jaroslav (advisor) ; Brábek, Jan (referee) ; Mráček, Tomáš (referee)
The resistance to tamoxifen, a drug used in the adjuvant therapy for hormone sensitive breast cancer, represents a major clinical obstacle. Although various mechanisms leading to tamoxifen resistance have been described and intensively studied, a significant number of patients still become resistant to the treatment and eventually relapse. Tamoxifen therapy has been shown to enrich tumors with cancer stem cells (CSCs), which are naturally resistant, and have self-renewal ability and the potential to form secondary tumors. Metabolic rewiring, altered iron metabolism and upregulation of ATP-binding cassette (ABC) transporters have been shown to be important in the maintenance of CSC phenotype. Therefore, we investigated these mechanisms as possible contributors to tamoxifen resistance in vitro in two tamoxifen resistant (Tam5R) cell lines that we established. We show that Tam5R cells have dramatically disassembled and less active mitochondrial supercomplexes (SCs) and higher level of mitochondrial superoxide, together with a fragmented mitochondrial network. Such dysfunction of mitochondria results in the AMP-activated protein kinase (AMPK) activation and metabolic rewiring towards glycolysis. Importantly, cells lacking functional mitochondria are significantly more resistant to tamoxifen, supporting...
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Molecular mechanisms of tamoxifen resistance in breast cancer
Tomková, Veronika ; Truksa, Jaroslav (advisor) ; Brábek, Jan (referee) ; Mráček, Tomáš (referee)
The resistance to tamoxifen, a drug used in the adjuvant therapy for hormone sensitive breast cancer, represents a major clinical obstacle. Although various mechanisms leading to tamoxifen resistance have been described and intensively studied, a significant number of patients still become resistant to the treatment and eventually relapse. Tamoxifen therapy has been shown to enrich tumors with cancer stem cells (CSCs), which are naturally resistant, and have self-renewal ability and the potential to form secondary tumors. Metabolic rewiring, altered iron metabolism and upregulation of ATP-binding cassette (ABC) transporters have been shown to be important in the maintenance of CSC phenotype. Therefore, we investigated these mechanisms as possible contributors to tamoxifen resistance in vitro in two tamoxifen resistant (Tam5R) cell lines that we established. We show that Tam5R cells have dramatically disassembled and less active mitochondrial supercomplexes (SCs) and higher level of mitochondrial superoxide, together with a fragmented mitochondrial network. Such dysfunction of mitochondria results in the AMP-activated protein kinase (AMPK) activation and metabolic rewiring towards glycolysis. Importantly, cells lacking functional mitochondria are significantly more resistant to tamoxifen, supporting...
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Expression and regulation of the ABC transporters in tumour cells
Tomková, Veronika ; Truksa, Jaroslav (advisor) ; Němcová, Vlasta (referee)
Estrogen signalling pathway plays crucial role in carcinogenesis of breast cancer. Estrogen receptor (ER) is a prototypical hormone receptor that upon binding its ligand, estradiol, translocates into the nucleus and turns on target genes related to cellular proliferation and survival. Although estrogen signalling physiologically supports normal breast tissue development, deregulations of this pathway contribute to development of breast tumours that are estrogen receptor dependent. One of the main obstacles in breast cancer treatment is acquired resistance to common anticancer drugs also known as multidrug resistance (MDR). The switch between chemotherapy responsive to chemotherapy resistant cell phenotype is usually accompanied by increased expression of ABC transporters, special membrane proteins responsible for export of various kinds of commonly used anticancer drugs from the intracellular to extracellular space and is also linked to the existence of cancer stem cells (CSCs). ABC transporters can not only export chemotherapeutic drugs but may modulate tumour microenvironment through the transport of endogenous intracellular substrates such as leukotrienes (LTs), sphingolipids and prostaglandins PGs). This function may also play important role in carcinogenesis. The aim of the thesis was to...
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The use of mood in concessive clauses in modern Spanish
Tomková, Veronika ; Čermák, Petr (advisor) ; Kratochvílová, Dana (referee)
Concessive sentences in Spanish are associated with different moods depending on the degree of certainty with respect to the speaker's testimony. Frequent types of the concessive sentences are those with the conjunction aunque and structures introduced by the preposition por. Individual types have the same general rules for the choice of indicative and subjunctive mood, but both types have different use of these moods. In this paper we first follow the standard rules of the choice of moods in the concessive sentences and then they are compared with the Spanish linguistic corpus CREA and with the parallel Spanish-Czech corpus InterCorp.
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Corporate Social Responsibility
Tomková, Veronika ; Štůsek, Jaromír (advisor) ; Kvasničková Stanislavská, Lucie (referee)
The topic of bachelor thesis is the Corporate Social Responsibility. The work is divided into two parts. The theoretical part describes the definition, basic principles of corporate social responsibility, such as Stakeholder Theory and Tripple Bottom line, and further explains the progress of the implementation cycle. In the practical part there are identified socially responsible behavior at a private college and it is proposed partial progress in the implementation of the concept of CSR in the company.
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