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Biotransformation of plant secondary metabolites and their modulatory effects on drug-metabolizing enzymes
Šadibolová, Michaela ; Boušová, Iva (advisor) ; Soukup, Ondřej (referee) ; Anzenbacherová, Eva (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Training Workplace Department of Biochemical Sciences Doctoral Degree Program Xenobiochemistry and Pathobiochemistry Candidate Mgr. Michaela Šadibolová Supervisor Assoc. Prof. PharmDr. Iva Boušová, Ph.D. Advisor Title of Doctoral Thesis Biotransformation of plant secondary metabolites and their modulatory effects on drug-metabolizing enzymes Sesquiterpenes and prenylflavonoids represent two classes of plant secondary metabolites that form an inherent part of human diet. They exert many beneficial biological activities, and accordingly, they are used as active constituents of herbal products. However, as xenobiotics, they also interact with a battery of drug-metabolizing enzymes and can in turn modulate their activity and/or expression, which may lead to herb-drug interactions. Sesquiterpenes and prenylflavonoids mentioned in this dissertation have been under-researched in this aspect. Three acyclic sesquiterpenes (farnesol, cis-nerolidol, trans-nerolidol) and three cyclic sesquiterpenes (α-humulene, β-caryophyllene, β-caryophyllene oxide) activated gene transcription mediated by pregnane X receptor; however, they did not alter the mRNA or protein expression of their downstream targets, namely cytochrome P450 (CYP) 3A4 and CYP2C, neither did...
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Video Dubbing Tool
Koňárek, Petr ; Soukup, Ondřej (referee) ; Křivka, Zbyněk (advisor)
This thesis deals with draft and implementation of a multi - platform dubbing tool . It is about video and audio processing , recording voice of separate voice actors and its subsequent editing . You can find a set of technologies that are used to solve these tasks and to ensure compatibility with various operating systems . The design is made to include all the necessary audio operations while preserving its simplicity . Finally , you will learn about the testing process of this tool in a fast - dubbing competition and the result of it .
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Project planning and management of construction of the bridge on the road II / 377
Soukup, Ondřej ; Kolečkářová, Barbara (referee) ; Kantová, Radka (advisor)
The subject of this thesis the construction and technological preparation for the construction of the bridge ev.č. 377-007 across the Býkovka river in the municipality Rájec - Jestřebí, which is part of the reconstruction of a main road II / 377 Bořitov - Rájec. The thesis is elaborated a technical report on the structural and technological project, coordinating construction situation, the situation with wider relationships routes following the stages, time and financial plan – by objects, study the implementation of major technological stages of the building SO203 project site equipment, design of the main construction machines and mechanisms, the timetable of the main building structure, workers deployment plan, plan of machines usage, a plan for securing material resources for SO 203, technological regulation for the implementation of bored piles of, inspection and test plan for pilots, budget SO 203, sequence diagram construction, control and monitoring plan and calculation of bearing capacity of the bridge foundation piles.
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Path-Controlled Grammars
Adamec, Ondřej ; Soukup, Ondřej (referee) ; Křivka, Zbyněk (advisor)
This thesis deals with path-controlled grammars, which are grammars that place restrictions on the paths in a derivation tree of a context-free grammar. The goal of this thesis is to create an algorithm for conversion between the path-controlled grammars and the state grammars, which is a di erent type of regulated grammars. Another goal is to study the generative power of path-controlled grammars based on the conversion algorithm. The conversion algorithm is implemented and tested on a number of path-controlled grammars. Also, its complexity is discussed. Finally, a parsing tool for path-controlled grammars is implemented. Complexity of this tool is analyzed as well.
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Automata with a Limited Number of Pure Pushdowns
Soukup, Ondřej ; Zemek, Petr (referee) ; Meduna, Alexandr (advisor)
Pushdown automata with limited number of pure pushdowns are specialization of pure pushdown automata. Examination of their power is mainly focused on the view of combinatorics of words. In language defined by automata we introduce term of dependence, which denotes relation between parts of strings in language. It is shown, how the defined automata proceed on processing of dependencies. Then the relation between distribution of dependencies in language and required number of pushdowns is derived. Also is defined the infinite hierarchy of languages corresponding to automata in dependence on number of their pushdowns. At the end belonging of the class of languages defined by pushdown automata with limited number of pure pushdowns to Chomsky hierarchy of languages is studied, but it is discovered, that they do not correspond to Chomsky hierarchy. Based on this result it is proposed to study possible changes of models as a future development. Then the simulating program is created to illustrate features of examined automata.
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Centre of Integrated Safety System
Soukup, Ondřej ; Sláma, Ing Ludvík (referee) ; Mohelníková, Jitka (advisor)
It is a new Centre of the Integrated Rescue System to p No. 375/2 in the cadastral Sand 720755th The project documentation is conducted only for the fire station. that consists of three dilated from buildings. Building for day stay is three-storey, two-storey garage with workshops and drying storey tower. Brick construction system based on the footings. Horizontal structure prestressed panels are at SPIROLL. The roof is flat, single-layer and desk hunter cased. Concrete floors are connected by a staircase in the building for day stay and welded steel in the drying tower.
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New Versions of Classical Automata and Grammars
Soukup, Ondřej ; Solár, Peter (referee) ; Meduna, Alexandr (advisor)
Tato diplomová práce se zabývá zkoumáním nových verzí automatů a gramatik a je proto rozdělena do dvou částí. První část definuje a studuje čisté více zásobníkové automaty a navíc zavádí úplná uspořádání nad jejich zásobníky nebo zásobníkovými symboly. Práce dokazuje, že zavedená omezení snižují vyjadřovací sílu automatů. Ve druhé části práce jsou definovány a popsány nové derivační módy gramatik s rozptýleným kontextem, které zobecňují relaci přímé derivace. Je dokázáno, že jejich použití nesnižuje vyjadřovací sílu gramatik.
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Formal Models of Distributed Computation
Soukup, Ondřej ; Horváth,, Géza (referee) ; Rogalewicz, Adam (referee) ; Meduna, Alexandr (advisor)
Tato disertační práce představuje derivační stromy několika různých typů gramatik ve zobecněné Kurodově normální formě; jmenovitě obecné a regulárně řízené gramatiky, gramatiky s rozptýleným kontextem a spolupracující distribuované gramatické systémy. Definuje jednoduché stromové rysy založené na kontextových vlastnostech jednotlivých diskutovaných gramatik a dokazuje, že pokud existuje limitující konstanta k taková, že každá věta generovaného jazyka L odpovídá řetězci listových uzlů derivačního stromu, ve kterém je výskyt definovaných stromových rysů omezen konstantou k, jazyk L je ve skutečnosti bezkontextový. Tato práce dále ukazuje, že dosažený výsledek představuje silný nástroj důkazu bezkontextovosti jazyka. Vše je doplněno příklady praktického využití nástroje.
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