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Developing of bussiness activities of GEOPEN company
Kašpar, Karel ; Sedlář, Jiří (referee) ; Koleňák, Jiří (advisor)
This bachelor’s thesis focuses on the analysis of the GEOPEN Ltd. company. The thesis contains an analysis and a consequent proposal for the development of the company’s business activities. The proposal contains the expansion of company activities by establishing an online shop which should contribute not only to the improvement of the company’s status on the market, but also to raising the saleability and the renown of the company.
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The suspension types of passenger Cars
Sedlář, Jiří ; Blaťák, Ondřej (referee) ; Porteš, Petr (advisor)
In this thesis there is mentioned the overview of types of axles, which are used by the current cars.Their working principle is described for each type of axle and it is also mentioned an example of usage for concrete car. In the thesis are listed marks and types of cars, which use this types of axles.
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Cutting tools for deep drilling and their use in practice
Sedlář, Jiří ; Kalivoda, Milan (referee) ; Jaroš, Aleš (advisor)
This bachelor thesis deals with tools for drilling deep holes. The first part is focused on the basic description of the drilling process, sorting the tools according to their construction and last but not least, sorting of the systems used for deep drilling. In the theses is further elaborated an overview of materials for the production of cutting tools and ways of coating, which are used the most nowadays. There is a constant development in coating, because of the better mechanical, physical and chemical properties in this field. The last part is dedicated to the definition of the tools for deep drilling and their use in practice.
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Design of a two-axis multi-spindle lathe carriage
Sedlář, Jiří ; Štěpánek, Vojtěch (referee) ; Hadraba, Petr (advisor)
This diploma thesis deals with the design of a two-axis multi-spindle lathe carriage. In the first part, there is made a research, and its aim is to find possible variants of design solutions. After the best rated variant was selected, the thesis further continues with the necessary technical calculations of the main design nodes such as a synchronous servomotor, ball screw, linear guide and bearing. The design itself was carried out with regard to calculations and the resulting model was examined in terms of dynamic stability. The subject of examination was to find the natural frequencies of the assembly and to determine the amplitudes of the oscillations which arise from the harmonic excitation force. Finally, Lobe diagrams for grooving and longitudinal turning operations were drawn.
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FPGA programmer
Sedlář, Jan ; Pristach, Marián (referee) ; Bohrn, Marek (advisor)
The work deals with the analysis of the realization of FPGA programmers. Its aim is to create a functional programmer. The proposal aims to minimize the components, their cost and area. The programmer should support chips from manufacturers Altera, Lattice and Xilinx. The programmer should enable support functions such as data transfer, virtual switches and the programming button.
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Race Car Roll Cage
Sedlář, Jiří ; Hejtmánek, Petr (referee) ; Blaťák, Ondřej (advisor)
Master thesis is about increasing of protection the crew in race car with changes in its roll-over protective structure according to current safety rules. For examination was used the Finite Element Method. The products of this thesis are different variation of roll cages, which are tasked to increasing the safety of existent race car.
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Comparative Markov state analysis of APOE protein dynamics by neural networks
Kopko, Jakub ; Sedlář, Jiří (advisor) ; Holeňa, Martin (referee)
This thesis leverages the CoVAMPnet neural network architecture to analyze the dy- namics of apolipoprotein E (APOE), a protein involved in the development of Alzheimer's disease. CoVAMPnet offers a versatile machine learning framework for extracting mean- ingful features from high-dimensional molecular dynamics data and constructing Markov state models to characterize protein conformational dynamics. By applying CoVAMPnet to APOE simulations, the thesis successfully captures the protein behavior by reveal- ing its key conformational states and structural transitions. These findings provide new insights into the dynamics of APOE and its potential role in Alzheimer's disease. The thesis also investigates the influence of a small molecule drug candidate 3SPA on APOE's conformational behavior, shedding further light on its therapeutic possibilities. Overall, this work demonstrates CoVAMPnet's effectiveness in analyzing and comparing the dy- namics of larger proteins in an interpretable manner, reinforcing its potential application for complex biomolecular studies. 1
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