Original title: Srovnávací analýza markovských stavových modelů pro dynamiku proteinu APOE pomocí neuronových sítí
Translated title: Comparative Markov state analysis of APOE protein dynamics by neural networks
Authors: Kopko, Jakub ; Sedlář, Jiří (advisor) ; Holeňa, Martin (referee)
Document type: Master’s theses
Year: 2023
Language: eng
Abstract: This thesis leverages the CoVAMPnet neural network architecture to analyze the dy- namics of apolipoprotein E (APOE), a protein involved in the development of Alzheimer's disease. CoVAMPnet offers a versatile machine learning framework for extracting mean- ingful features from high-dimensional molecular dynamics data and constructing Markov state models to characterize protein conformational dynamics. By applying CoVAMPnet to APOE simulations, the thesis successfully captures the protein behavior by reveal- ing its key conformational states and structural transitions. These findings provide new insights into the dynamics of APOE and its potential role in Alzheimer's disease. The thesis also investigates the influence of a small molecule drug candidate 3SPA on APOE's conformational behavior, shedding further light on its therapeutic possibilities. Overall, this work demonstrates CoVAMPnet's effectiveness in analyzing and comparing the dy- namics of larger proteins in an interpretable manner, reinforcing its potential application for complex biomolecular studies. 1
Keywords: Machine learning for molecular dynamics|Neural networks|Variational approach to Markov processes|Markov state models|APOE protein; Strojové učení pro molekulární dynamiku|Neuronové sítě|Variační přístup k Markovským procesům|Modely Markovských stavů|APOE protein

Institution: Charles University Faculties (theses) (web)
Document availability information: Available in the Charles University Digital Repository.
Original record: http://hdl.handle.net/20.500.11956/183994

Permalink: http://www.nusl.cz/ntk/nusl-534291


The record appears in these collections:
Universities and colleges > Public universities > Charles University > Charles University Faculties (theses)
Academic theses (ETDs) > Master’s theses