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Specifics of work with children in foster care during the educational process at primary school
Mužíková, Michaela ; Komárková, Tereza (advisor) ; Sedláčková, Daniela (referee)
The Diploma Thesis focuses on the issue of children in foster care and the specifics of pedagogical work in elementary school. The theoretical part is divided into four chapters. The first chapter describes the system of substitute family care and the definition of foster care, the second chapter describes foster care in the Czech Republic, while the third chapter focuses on child in foster care and its possible specific manifestations. The fourth chapter provides an insight into the issue of education and possible specifics during the upbringing and education of children in foster care at elementary school. The practical part follows up on the theoretical part and focuses on qualitative research mapping the implementation of upbringing and education of children in foster care at elementary school. The goal of the research is to find out how the specifics of children in foster care are taken into account during the educational process at elementary schools. The research has the form of case studies. The employed data collection method was semi- structured interviews. The interviews revealed that foster care and child support can have a positive effect, among other things, on school achievements. A pupil brought up in foster care does not have to show any problematic or specific tendencies during...
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Using of genetically modified cells lines to study transport processes in in vitro kidney models.
Mužíková, Michaela ; Smutná, Lucie (advisor) ; Trejtnar, František (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Student: Michaela Mužíková Supervisor: PharmDr. Lucie Smutná, PhD. Title of diploma thesis: Using of genetically modified cells lines to study transport processes in in vitro kidney models Transport processes in renal cells are mostly secured by proximal tubule transporters. These transporters mediate excretion and reabsorption of wide variety of endogenous and exogenous substances, including xenobiotics. Within the broad spectrum of many drug-transporting proteins, we have chosen the glycoprotein megalin (LRP2), a receptor involved in the reabsorption of albumin and other endogenous substances, such as insulin or hemoglobin. Peptide and aminoglycoside antibiotics represented by e.g., gentamicin and belongs between LRP2 ligands. The diploma thesis deals with the development and utilization of the LRP2 knockout cell lines in accumulation studies. The experiments were performed using human cell lines naturally expressing LRP2, the JEG-3 and HK-2. Several genetically modified cell lines expressing unfunctional LRP2 and consequently exerting harmed ability of model ligand internalization were prepared using the CRISPR/Cas9 technique. The effect was confirmed by accumulation studies with FITC-albumin....
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Using of genetically modified cells lines to study transport processes in in vitro kidney models.
Mužíková, Michaela ; Smutná, Lucie (advisor) ; Trejtnar, František (referee)
Charles University Faculty of Pharmacy in Hradec Králové Department of Pharmacology and Toxicology Student: Michaela Mužíková Supervisor: PharmDr. Lucie Smutná, PhD. Title of diploma thesis: Using of genetically modified cells lines to study transport processes in in vitro kidney models Transport processes in renal cells are mostly secured by proximal tubule transporters. These transporters mediate excretion and reabsorption of wide variety of endogenous and exogenous substances, including xenobiotics. Within the broad spectrum of many drug-transporting proteins, we have chosen the glycoprotein megalin (LRP2), a receptor involved in the reabsorption of albumin and other endogenous substances, such as insulin or hemoglobin. Peptide and aminoglycoside antibiotics represented by e.g., gentamicin and belongs between LRP2 ligands. The diploma thesis deals with the development and utilization of the LRP2 knockout cell lines in accumulation studies. The experiments were performed using human cell lines naturally expressing LRP2, the JEG-3 and HK-2. Several genetically modified cell lines expressing unfunctional LRP2 and consequently exerting harmed ability of model ligand internalization were prepared using the CRISPR/Cas9 technique. The effect was confirmed by accumulation studies with FITC-albumin....
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The importance and responsibilities of the Curator for youth in the Capital City of Prague
Mužíková, Michaela ; Cimrmannová, Tereza (advisor) ; Stretti, Sylvie (referee)
The Diploma thesis "The importance and responsibilities of the Curator for youth in the Capital City of Prague" focuses on explaining of work of curators for youth, his responsibilities and work with institutions, which cooperate with curators. Whole topic is hugely supported by case studies of clients. This work consists of introduction which characterizes the aim of the thesis. Next part contains basic terms and describes activity of the curator for youth. Diploma thesis also focuses on institutions, responsibilities and difficulties of work of curator for youth. Next part is about cases. This part consists of case studies of clients, these case studies are from clients of department of social prevention from curators for youth of Prague 10. Next part is The Discussion, which compares differencies between theory and practise. This Diploma thesis contributes to understanding the work of curators for youth.
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The importance and responsibilities of the Curator for youth in the Capital City of Prague
Mužíková, Michaela ; Cimrmannová, Tereza (advisor) ; Stretti, Sylvie (referee)
The Diploma thesis "The importance and responsibilities of the Curator for youth in the Capital City of Prague" focuses on explaining of work of curators for youth, his responsibilities and work with institutions, which cooperate with curators. Whole topic is hugely supported by case studies of clients. This work consists of introduction which characterizes the aim of the thesis. Next part contains basic terms and describes activity of the curator for youth. Diploma thesis also focuses on institutions, responsibilities and difficulties of work of curator for youth. Next part is about cases. This part consists of case studies of clients, these case studies are from clients of department of social prevention from curators for youth of Prague 10. Next part is The Discussion, which compares differencies between theory and practise. This Diploma thesis contributes to understanding the work of curators for youth.
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Presentation of the Czech Presidency in the daily Le Monde
Mužíková, Michaela ; Jungová, Eliška (advisor) ; Klabíková Rábová, Tereza (referee)
Bachelor thesis "Presentation of the Czech presidency in the daily Le Monde" focuses on the analysis of the media picture of the Czech Republic and its representatives on the events taking place during the first part of year 2009. The qualitative and quantitative analysis of the media content was used for the treatment of data, have been categorized into four levels. The first level is concerned about the Czech euroskeptic picture, after the Czech presidency is represented by its agenda and of course by domestic political situation in the Czech republic, too. The last level of this study focuses on the evaluation by the daily Le Monde and on the next presidency which started at that moment.
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