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Analysis of drug administration by nurses in health facility IX
Novotná, Michaela ; Malý, Josef (advisor) ; Kolmanová, Eliška (referee)
Analysis of drug administration by nurses in health care facility IX Author: Michaela Novotná Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: Mgr. Ondřej Tesař Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Kralové, Charles University Introduction and objective: In drug administration, the safety or efficacy of pharmacotherapy can be affected by medication errors that can occur at any time in the drug handling process and are due to human factor errors. The aim of the practical part of thesis was to identify and analyze the administration of drugs by nurses to patients in a healthcare facility. Methodology: In both the 1st (pilot) phase and the 2nd phase of data collection, the direct observation method was used. An observer (the study investigator) monitored morning, midday and evening oral drug administration during 30 working days in December 2023 and in January 2024 in four wards of one hospital. The following parameters associated with drug administration were observed and recorded: patient information, patient identification, hygiene rules, drugs prescribed and administered, triple checking of the originality of drug, generic substitution, time interval between drug administration and meal, control of the use of the drug, beverage with which drug was washed down,...
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Analysis of drug administration by nurses in health facility XVI.
Straková, Daniela ; Malý, Josef (advisor) ; Doseděl, Martin (referee)
Charles University Faculty of Pharmacy in Hradec Kralove Department of Social and Clinical Pharmacy Author: Daniela Strakova Thesis supervisor: doc. PharmDr. Josef Maly, Ph.D. Consultant: Mgr. Ondrej Tesar Title of thesis: Analysis of drug administration by nurses in health facility XVI. Introduction Medication errors are a very common problem that can arise at different levels and can lead to disruptions in the safety and effectiveness of the provided healthcare. The analysis of medication errors can help to improve the quality of patient care. Objective The aim of the practical part of this thesis was to describe and analyse the observed errors in the administration of medicines by a nurse in a healthcare facility. Methodology For the thesis, the method of direct observation by a trained team (pharmacist, nurse) was chosen and errors in the administration of drugs by the nurse to hospitalized patients were recorded. The observation took place in three departments of the hospital during January 2023. These departments were surgery, internal medicine and the aftercare unit. The collection took place on three consecutive days during morning, midday and evening drug administration to the patients. Parameters monitored were: patient information (e.g. age, medications used), nurse information (e.g....
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Analysis of drug administration by nurses in health facility VIII
Vaclaviková, Iveta ; Malý, Josef (advisor) ; Šorf, Aleš (referee)
Author: Iveta Vaclaviková Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: Mgr. Ondřej Tesař Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Medication errors contribute significantly to the occurrence of adverse events that can impact patient health. The aim of this thesis was to analyze the administration of drugs to patients hospitalized by nurses in one of four studied health facilities in the South Bohemia region in the surgical, internal medicine and aftercare wards. Methods: This diploma thesis is part of an observational-interventional study, in years 2020- 2023. Observations took place in internal medicine, surgery and aftercare wards. Collection of data was held from 23th May to 26th May 2022 by a multidisciplinary team made up of a pharmacist and a nurse by direct observation method. These following data were collected: information about pacient (e.g., gender, age, and any medications taken), information about the nurse by whom the medications were administered (e.g., age, years of experience, highest educational attainment), and information recorded during the actual administration of the medications (e.g. nurse compliance with hygiene requirements; patient identification; checking originality of the drug; whether the...
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Analysis of the possibilities of influencing antibiotic prophylaxis in orthopedics on the basis of inflammatory markers
Preiss, Přemysl ; Malý, Josef (advisor) ; Doseděl, Martin (referee)
Analysis of the possibilities of influencing antibiotic prophylaxis in orthopedics on the basis of inflammatory markers Author: Přemysl Preiss Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: PharmDr. Petr Domecký Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aim: Endoprosthetic surgeries are demanding orthopedic surgeries rarely associated with complications, that can be fatal. One is periprosthetic joint infection (PJI), whose risk can be decreased by antibiotic prophylaxis (AP). The aim of this effort was to describe trends in endoprosthetic surgeries of the knee and the hip, their complications and options of diagnostics in the theoretical part. The aim of the practical part was to analyze prognostic features of chosen laboratory parameters on postoperative infections, respectively on postoperative complications. Methods: This prospective study started in March 2020 and data gathering took place until 28. 3. 2022 at the Ortopedic Clinic of the University Hospital Hradec Králové. Patients, who were included in the study, fulfilled the preliminary criteria, e.g. age ≥ 18 years, patient undergoing total hip or knee arthroplasty at the time of the study and giving the informed consent to the study. Data were gathered from...
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Measuring adherence in patients with oral targeted therapy in chronic lymphocytic leukaemia
Hanusová, Barbora ; Malý, Josef (advisor) ; Kolmanová, Eliška (referee)
Measuring adherence in patients with oral targeted therapy in chronic lymphocytic leukaemia Author: Barbora Hanusová Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: PharmDr. Petra Rozsívalová Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Chronic lymphocytic leukaemia (CLL) is a hematological disorder characterized by clonal proliferation of mature B-cells. New oral targeted drugs have been used in clinical practice to treat CLL. The aim of this thesis was to measure adherence to oral targeted drugs, analyze pharmacotherapy and identify drug-related problems (DRP) and their management. Methods: The cross-sectional pilot study ran from September 2022 to March 2023 in University Hospital Hradec Králové. Patients ≥ 18 years old, with CLL diagnosis treated with ibrutinib, acalabrutinib or venetoclax were included. Medical data and pharmacotherapy were obtained using electronic medical records and patients' medication records. Guided interviews were performed to measure patients' adherence to oral targeted oncolytics using Czech version of The Basel Assessment of Adherence to Immunosuppressive Medications Scale (BAASIS-CZ) and determine their opinions about medicine using Czech translation of The Beliefs about Medicines...
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Analysis of drug administration by nurses in health facility II
Bančíková, Natalie ; Malý, Josef (advisor) ; Horký, Pavel (referee)
Analysis of drug administration by nurses in a health facility II Author: Natalie Blizňáková Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: Mgr. Ondřej Tesař Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aim: Medication errors are one of the main causes of adverse events that can lead to damage to health or death of the patient. The aim of this work was to analyze the administration of drugs by nurses to patients hospitalized in one health facility providing inpatient care in the South Bohemian region with emphasis on medication errors and their prevention. Methodology: This diploma thesis is part of a long-term observation-intervention project, which takes place in the years 2020-2023. The surgical, internal medicine and aftercare departments were observed. Data collection for this work took place in the form of direct observation by a trained team of pharmacists and nurses, from June 28 to July 1 and from August 23 to August 26, 2021, for three consecutive days. The following data were collected: patient data (e.g., age; gender; all drugs used), data on the nurse administering the drugs (e.g., length of practice and education) and data on the actual administration of drugs (e.g., method of patient identification; nurse...
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Analysis of drug-drug interactions in patients admitted to hospital (II.)
Mašková, Daniela ; Vlček, Jiří (advisor) ; Malý, Josef (referee)
Candidate: Daniela Mašková1 Supervisor: prof. RNDr. Jiří Vlček, CSc.1 Consultant: PharmDr. Zuzana Očovská1 Title of the master thesis: Analysis of drug-drug interactions in patients admitted to hospital (II.) 1 Department Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Drug-drug interactions (DDIs) are part of drug-related problems. Drug-related problems can be either potential (possibly leading to real problems for the patient) or manifest (the problem already impacts the patient). This study aims to identify potential DDIs in the medication history of patients acutely admitted to University Hospital Hradec Králové via the department of emergency medicine. The objectives are to determine the prevalence of hospital admissions with at least one potential DDI in the medication history and characterize the identified potential DDIs with respect to their mechanism, severity rating, level of documentation, and potential consequences. Another objectives was to identify medication classes involved in potential DDI. The design of this study is an observational cross-sectional study. The data were obtained from the previous study examining the drug-relatedness of 1252 hospital admissions. For the purpose of my master's thesis, a sample of 378 hospital admissions was...
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Analysis of consultations provided to patients in a pharmacy I.
Feřtová, Lada ; Malý, Josef (advisor) ; Kolmanová, Eliška (referee)
Analysis of consultations provided to pacients in pharmacy I. Author: Mgr. Lada Feřtová Supervizor: doc. PharmDr. Josef Malý, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aim: Providing of individual consulting activities (ICA) to pharmacy clients (CL) is one of the options how to improve understanding of their health condition. The objective of this thesis was to analyze ICA focused on blood pressure (BP) measuring in given pharmacies and management of drug-related problems (DRP) associated with used pharmacotherapy. Methodology: The data was collected in community pharmacies in Poděbrady, Česká Lípa, Praha, Moravská Třebová and Kralovice in 2012-2016 period. Data colectlion consisted of 4 parts. First part was structured interview between CL and the researcher. During this interview, CL was asked for socio- demographic variables, risk factors (RF) for arterial hypertension (AH) or atherosclerosis, presence of other illness in anamnesis, medicines taken and also personal experience with BP measuring and CL's opinion on health problems related to BP. Then, the BP was measured based on valid recommended procedure defined by Czech Chamber of Pharmacists with calibrated tonometr. When measuring was finished, researcher's...
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Analysis of the Drug Related Problems in Facilities for Seniors I.
Duchoňová, Veronika ; Malý, Josef (advisor) ; Horký, Pavel (referee)
Analysis of the Drug Related Problems in Facilities for Seniors I. Author: Veronika Duchoňová1 Tutor: Josef Malý1 1 Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aim: The aim of the thesis was to revise the medical documentation in the aftercare health facility, to classify the identified drug related problems (DRP) and to describe the chosen DRP by the SAZE principals. Methodology: The data collection for this thesis took place in ONLP in the time period from the 27th of August to the 30th of August 2019. The aim of the auditors was a revision of phamacotherapy of all 76 patients. A complete electronic and printed medical documentation was provided. The DRP were identified based on the information about a patient and described by the SAZE principals. The DRP were reported in the electronic database according to the modified PCNE classification V5.01. All obtained data was exported to the Microsoft Office Excel in the form of tables and processed by freqency analysis. Six case studies with the detailed description of the patient and the pharmacist's analysis by the SAZE principals were demonstrated. The conclusion of the audit was presented to doctors and the DRP were discussed at educational seminar. Results: From total of 76...
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Analysis of patient adherence to treatment by DOAC I
Rezáková, Katarína ; Malý, Josef (advisor) ; Smejkalová, Lenka (referee)
Analysis of patient adherence to treatment by DOAC I Author: Katarína Rezáková Tutor: doc. PharmDr. Josef Malý, Ph.D. Consultant: PharmDr. Kateřina Malá, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Atrial fibrillation (AF) is the most common supraventricular tachyarrhythmia associated with increased morbidity and mortality. In clinical practice, direct oral anticoagulants (DOAC) are used as an alternative to warfarin to prevent thromboembolic events in patients with AF. The study aimed to analyse the statements of patients with FiP along with data from medical records focusing on aspects related to the use and management of DOAC, including devices and tools to improve adherence to treatment, patients' level of awareness of DOAC and other therapeutic agents used. Methods: The prospective study was conducted from 2020 to 2022 at the University Hospital Brno. Patients aged ≥ 18 years with AF on DOAC therapy (dabigatran, rivaroxaban and apixaban) were included in the study. Data about pharmacotherapy and patients' health status were obtained from medical records and structured interview with the patient. Patients' interviews were performed at time 0, three and six months after patient has entred the study....
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