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Biogenesis of plasma membrane Na+/H + antiporters of eukaryotic cells
Černá, Karolína ; Zimmermannová, Olga (advisor) ; Groušl, Tomáš (referee)
A secretory pathway is a process which serves for maturation of approximately one third of nascent polypeptides during proteosynthesis. Correct function of each membrane protein depends on their effective transport into its target membrane. An important group of proteins interacting with maturating proteins and ensuring their pass through the secretory pathway are cargo receptors. Cargo receptors help to insert nascent proteins into COPII vesicles via which they are exported from endoplasmic reticulum to Golgi apparatus. Erv14 belongs to characterized cargo receptors in yeast. Based on similarity with this cargo receptor several homologous cargo receptors were also identified in higher eukaryotes, including human. Na+ /H+ antiporters are among membrane proteins passing the secretory pathway and requiring a cargo receptor for their biogenesis. The aim of this work is to summarize knowledge of the role of Erv14 cargo receptor and its human homologs CNIH1-4 in biogenesis of monovalent cation transporters, including Na+ /H+ antiporters. Key words: Na+ /H+ antiporters, Erv14, CNIH, cargo receptors, secretory pathway
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Slums as a result of urbanization of poverty in Africa
Černá, Karolína ; Sládek, Jan (advisor) ; Duffková, Jana (referee)
This thesis deals with the issue of slums in Africa with a focus on its eastern region. First part presents information on the fundamental aspects of this issue in theory line, when primarily uses foreign publications. It specifically focuses on the influence of post- colonialism, the process of urbanization and the incidence of slums. Second part illustrates the situation on the example of slums in Nairobi and Addis Ababa. Its main purpose is to show the quality of life of local population. Analysis is performed by the three studies; one refers to Nairobi and two Addis Ababa. It also seeks to answer the research questions that are listed at the beginning of this part. Overall results suggest that local people live in very poor conditions which do not provide adequate housing, access to infrastructures and education, and the unemployment rate is very high. Keywords Urbanization, poverty, slums, inequality, capital
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Legal penalties for unfair competition
Černá, Karolína ; Patěk, Daniel (advisor) ; Liška, Petr (referee)
Legal Penalties for Unfair Competition As the unfair competition has become the part of business due to the fact that businessmen are trying to achieve the profit, it is necessary to set up legal rules and restrictions to assure the fair competition, i.e. competition without unfairness and negative effect on functionality of the economic competition. The aim of the diploma thesis is to analyse legal penalties of unfair competition especially in Czech legal order by means of interpretation of affected legal provisions together with judicature of the Supreme Court and other courts. First part of the thesis concerns theoretical scope of legal concepts concerning the unfair competition. The second chapter deals with active and passive legitimacy of subjects according to the Commercial Code. Both chapters give the theoretical framework for the whole thesis. The core of the diploma thesis is the third and fourth part, whereas the third part concerns the means of protection against unfair competition which are divided into several groups according to the law in which they are regulated (private law, public law divided into administrative and penal law, European law) and focuses on private law with using rich judicature of Czech courts. The fourth part regards specific procedural institutes that are...
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Extraordinary appeal in Common Plea
Černá, Karolína ; Winterová, Alena (advisor) ; Dvořák, Bohumil (referee)
Extraordinary appeal in common plea represents one of extraordinary remedies which should be the last possibility of judicial review of decisions issued by lower court instance provided by the general court even though such decisions are legitimate. In connection with previous it is necessary that regularization is set in such manner that the interference with the legal relations is insignificant in comparison with interest for review and reach of justice. Within the extraordinary appeal the Supreme Court fulfils its two fundamental functions, i.e. ensuring of individual rights and also consolidation of judgements and completion of law. It is this balance of two functions which have resulted in issuance of quite a lot of amendments to Civil Procedure Code related to the extraordinary appeal in past, thus it is possible to state that the actually valid legal regulation (in its basic outlines) has been de facto same as of the effectiveness of Act no. 404/2012 Coll. Most of amendments were connected with admissibility of the extraordinary appeal which sets the principles for fulfilment of the Supreme Court functions. Determination of admissibility qualification together with determination of reason for extraordinary appeal mean some of essentials of extraordinary appeal which cause difficulties to...
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Implementation of the SDGs to the Czech Republic - identification of priorities in terms of the Sustainable Development Goals
Černá, Karolína ; Kopečný, Ondřej (advisor) ; Kváča, Vladimír (referee)
The master thesis focuses on the process of implementation of global strategies to the national policy of the Czech Republic. The thesis is a case study. Its subject is global strategy the 2030 Agenda for Sustainable Development and the Czech strategic framework Czech Republic 2030. The first part of the thesis presents current knowledge of the sustainable development and dealing with global strategies in this field in the Czech Republic. The theoretical background of the own research is a theory of politics network and a theory of global governance. The aim of the thesis is not only to describe and explain the process of implementation of the 2030 Agenda for Sustainable Development to the Czech national policy, but also to define roles of groups of actors and to evaluate the participatory approach which was newly chosen for the Czech Republic 2030. The second part of the thesis is focused on the own research which was based on the analysis of relevant documents and semi-structured interviews with eleven experts (representatives of the Public administration, private sector, trade union, academic community and NGOs). One of the main contributions of this thesis is a comparison of the process of creating the Czech strategic framework for sustainable development from 2010 and the new system that was...
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Slums as a result of urbanization of poverty in Africa
Černá, Karolína ; Sládek, Jan (advisor) ; Duffková, Jana (referee)
This thesis deals with the issue of slums in Africa with a focus on its eastern region. First part presents information on the fundamental aspects of this issue in theory line, when primarily uses foreign publications. It specifically focuses on the influence of post- colonialism, the process of urbanization and the incidence of slums. Second part illustrates the situation on the example of slums in Nairobi and Addis Ababa. Its main purpose is to show the quality of life of local population. Analysis is performed by the three studies; one refers to Nairobi and two Addis Ababa. It also seeks to answer the research questions that are listed at the beginning of this part. Overall results suggest that local people live in very poor conditions which do not provide adequate housing, access to infrastructures and education, and the unemployment rate is very high. Keywords Urbanization, poverty, slums, inequality, capital
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Legal penalties for unfair competition
Černá, Karolína ; Patěk, Daniel (advisor) ; Liška, Petr (referee)
Legal Penalties for Unfair Competition As the unfair competition has become the part of business due to the fact that businessmen are trying to achieve the profit, it is necessary to set up legal rules and restrictions to assure the fair competition, i.e. competition without unfairness and negative effect on functionality of the economic competition. The aim of the diploma thesis is to analyse legal penalties of unfair competition especially in Czech legal order by means of interpretation of affected legal provisions together with judicature of the Supreme Court and other courts. First part of the thesis concerns theoretical scope of legal concepts concerning the unfair competition. The second chapter deals with active and passive legitimacy of subjects according to the Commercial Code. Both chapters give the theoretical framework for the whole thesis. The core of the diploma thesis is the third and fourth part, whereas the third part concerns the means of protection against unfair competition which are divided into several groups according to the law in which they are regulated (private law, public law divided into administrative and penal law, European law) and focuses on private law with using rich judicature of Czech courts. The fourth part regards specific procedural institutes that are...
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Electromigration behaviour of polyelectrolyte-ionic surfactant complexes and block copolymer vesicles
Černá, Karolina ; Zusková, Iva (advisor) ; Dubský, Pavel (referee)
Capillary zone electrophoresis (CZE) is not only a widely used analytical separation method, but it is also an important technique for determining physico-chemical parameters of materials. Significant use is also in the characterization of potentially interesting macromolecular substances. In this master's thesis, CZE was applied to the study of polyelectrolyte−oppositely charged ionic surfactant complexes. For the first studied complex formed by poly(ethylene oxide)-block-poly(sodium methacrylate) and surfactant N- dodecylpyridinium chloride, the electrophoretic mobility of surfactant depending on the ratio of surfactant concentration in the sample to the concentration of polyelectrolyte present in the background electrolyte was measured. However, we did not get the significant decrease in mobility as was predicted in the literature based on measuring the ζ-potential. This can be explained by the low stability of the complex in an electric field. The second system, the polyelectrolyte−surfactant complex of cationic−neutral hydrophilic block copolymer poly[3,5-bis(trimethylammoniummethyl)-4-hydroxystyrene iodide]-block-poly(ethylene oxide) and surfactant sodium dodecyl sulfate, could not be characterized using conventional CZE experiments described. The reason was probably due to a strong interaction of...
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Environmental impact assessment of projects
Černá, Karolína ; Žákovská, Karolina (advisor) ; Sobotka, Michal (referee)
The topic of this thesis is Environmental Impact Assessment (EIA). This is a very significant cross-sectional and preventive environmental protection tool. Its purpose is to identify as soon as possible any probable averse environmental impacts of presented project proposals. The whole process is led by a competent state offices. Necessary expert participants of the procedure are so-called "authorized persons" supplying specific technical studies on which the impact assessment is made. Another important factor, public participation, helps to improve efficiency of the EIA process. The whole procedure results in so-called Statement, which should define necessary conditions for the implementation of the project in effort to minimize negative impacts. If the project proposal is unacceptable under any circumstances it can not be given a consent to implement it and the statement must reject it. Conclusions formulated in the Statement serve as a basis for administrative decisions on project approval. Given the considerable breadth of the thesis topic it is focused on several key tasks, namely to provide a comprehensive explanation of the legal development of the EIA process, to analyze its current legislation and mapping legal rules of public participation in the EIA process. The following section...
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