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Determination of pharmaceuticaly important substances using High Performance Liquid Chromatography with Mass Spectrometry detection
Barrett, Blanka ; Jelínek, Ivan (advisor) ; Feltl, Ladislav (referee) ; Cvačka, Josef (referee)
L, L- L. l_ t__ L- INTRoDacrtoN High peďommce liquid chromatography (HPLC) is the most common method used in commercial malÍlcal laboratories. HPLC in combination with Mss speďIometry (MS) is frequmtly used for the detemination of drugs in hmm plasma md it belongs to gÍoup of methods that enable new md modem modifications. That is why following new trmds, which broadm the field of application of these methods. is so importmt. HPLC with Ms detection (HPLc-Ms) satisfy demmd for automation of detemination of smples from complex matrixes, which lead to elimination of humm enor, decreme of *penditure of maly,tical process md finally hildling potentially dmgerous smples by laboratory stďl Hrghly sensitive methods that do not require time consuming smple pre-teatment ue desired for phmacokinetic (PK) studies. Double MS (Ms/Ms) detection provides drugs identification md hgh sensitivity fol qumtitative detemination- It effectively eliminates inteďerences from endogenous impurities md guďmtees method selectivity at the sme time- Phmacokinetic (PK) studies detemine phmacokinetic chďactgistics of particulr drug that ile thm used to assess the bioequivalence of detemined drug vqsus othď chosm dÍug of the same nafurc' The PK paÍmetqs ďe calculated from the plmma concentrations of the drug detmined by a validated method'...
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Hypermedia APIs and their use for enhancing integration of IT services
Annau, Mike ; Šebesta, Michal (advisor) ; Jelínek, Ivan (referee)
This paper's aim is to design and implement a tool transforming REST Web APIs into APIs which facilitate the integration process. The improvement of integration is mainly divided into two parts: The embedding of semantic data in order to establish a common understanding of objects, properties and relations and the possibility to navigate through the API structure in an easy and automated way. The theoretical part is dealing with the fundamentals of Web APIs, today's related trends and the API's shortages and points of improvement. Another objective of this paper is to compare current data standards of output formats for so called Hypermedia APIs, whereas the most suitable components will be chosen as the output format of this paper's resulting tool. The practical part is dealing with the design and implementation of the tool being developed. Included, there is the description of test scenarios, related benefits for the tool's users as well as a final evaluation of the resulting tool and a discussion of the tool's future potential. The benefits of the tool are evaluated in a case study.
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Protection against DDoS attacks in the cloud computing
Vavroch, Zdeněk ; Karkošková, Soňa (advisor) ; Jelínek, Ivan (referee)
DDoS Attacks are nowadays huge threat on the internet. Many people and companies are dependent on accessibility of their data, services or applications. And that is what attackers try to abuse. In some cases, site or application that is not working, can make very bad name for the company in public. DDoS attacks are dangerous for people working at home, for corporate networks and mainly for huge clouds. Cloud are often targets of attacks because of how many people are affected by it. This thesis is focused on types of DDoS attacks we know and goal of the thesis is to find best defense solutions, mainly for defending the cloud computing. I will choose and describe the most common methods we know and use. In theoretical part I will describe what is cloud computing and DDoS attacks and what types of DDoS we know. In practical part I will describe the most common and efficient methods of defense.
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Analysing company's behaviour and communication on social networks
Němec, Milan ; Molnár, Zdeněk (advisor) ; Jelínek, Ivan (referee)
This thesis focuses on measuring company´s communication and behaviour on social networks. To capture the interaction between the company and its users the thesis uses web analytics tools. Therefore, the main objective of the thesis is analysis of these tools. To achieve this goal, the thesis characterizes social networks and their marketing opportunities for business promotion. Thanks to this, needs of using these tools is identified. The needs are: competitive analysis, optimizing communication, measuring achievement of objectives or detection competitive viral content. Research questions were determined and then analysis tools found answers to research questions. It was found that the tools provide various views of data and create a complete system for measuring and analysing behaviour and communication companies on social networks. The results were validated in a case study focused on the Facebook profile of the University of Economics in Prague. The study analysed the interaction profile of the school and its users and compared with others schools. In the results the analysis tools are validated and it is designed recommendation for improve engagement. This thesis revealed strengths and weaknesses of tools for measuring company´s communication and behaviour on social networks. It was found that these tools have wide range of use. They can be used for understanding the company's profile, its users, for purposes of competitive analysis, monitor corporate goals and optimize communications on social networks.
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Virtual image of Czech gaming community on social networks
Ryneš, Jakub ; Jelínek, Ivan (advisor) ; Samec, Marek (referee)
Bachelor thesis deals with analysis of gaming community in Czech Republic using social network Facebook. Thesis has 3 main goals. Find out how differ preferences of Czech video game players in comparison to the rest of the world. Secondly, chart popularity of several gaming platforms in Czech Republic. Third goal is to find out how Czech gamers perceive large competing game publishers. Thesis is divided into two main parts, theoretical and practical. There are definitions of terms related to video games and social networks in theoretical part, altogether with selection of appropriate candidates for analysis. Practical part is divided into three chapters accordingly to three main goals. To fulfill first goal there are analyzed the most favorite games, genres and websites about gaming. In next chapter is analyzed popularity of gaming platforms and the final chapter of the practical part includes popularity analysis of two large game publishers. There is analyzed so-called word-of-mouth of games fans which was collected from social network Facebook. Results are compared with each other and also with results from background research. Based on collected data, it is possible to prepare better marketing strategies for Czech market. It also can be used by game publishers because they can rethink their attitude towards their fans.
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Extensibility of open-source platforms for online shopping on Czech market
Mišenko, Jakub ; Šebesta, Michal (advisor) ; Jelínek, Ivan (referee)
The main subject of this thesis is an analysis of open source platforms and their add-ons for online shopping in Czech market. The aim is to describe various open source platforms and chart available add-ons, such as shipping and logistics, connection with accounting systems, payment methods, price comparison and similar add-ons, which extend functionality of an e-shop. This work also presents the installation of PrestaShop and its basic add-ons, which are compared to similar paid add-ons.
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ICT trends in the Far East (Japan and South Korea)
Bartošová, Katarína ; Samec, Marek (advisor) ; Jelínek, Ivan (referee)
This thesis is focused on development of ICT trends in Asian countries, specifically Japan and South Korea. The first part focuses on the description of the economic situation and the state of ICT market in both countries. Using the analytical methods of professional articles, the second part describes the selected ICT trends, the outline of their possible future developments, government intervention and dominant companies with projects in the areas concerned. The selected trends are then compared with the developments in the US and Europe. Described key trends include cloud computing, Internet of Things, artificial intelligence, 3D printing and a third platform.
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Vietnam ICT trends in the global and regional context
Le Tien, Lam ; Samec, Marek (advisor) ; Jelínek, Ivan (referee)
This thesis is focused on ICT market, its current situation analysis with Asia's countries, Vietnam as a focal point. The first part contains information about the current state of the Vietnamese economy. Following parts are dedicated to current ICT trends and comparison of the ICT market in Vietnam with trends around the world and neighbouring countries in the region. Main focus of this thesis is identification of key ICT trends and possibilities of their future development. The contribution of this paper is to evaluate current developments in the field of ICT trends in Vietnam.
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