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Attitudes and beliefs on HPV infection and vaccination
Blašková, Dominika ; Zimčíková, Eva (advisor) ; Pokladníková, Jitka (referee)
ATTITUDES AND KNOWLEDGE OF HPV INFECTION AND VACCINATION Author: Dominika Blašková Supervisor: PharmDr. Eva Zimčíková, Ph.D. INTRODUCTION Human papillomavirus (HPV) is a DNA virus. The virus causes benign and malignant diseases of men and women such as laryngeal papillomatosis, genital warts, oropharyngeal carcinoma, cervical cancer, penile cancer and anus cancer. HPV can be prevented by appropriate precautionary measures. The main preventative method is vaccination against HPV. Besides vaccination, regular screening is necessary to detect premalignant changes on time. AIMS The aim of the theoretical part of the diploma thesis was to summarize the information about HPV, the diseases caused by human papillomavirus and vaccination against HPV, the main preventive measure. The primary aim of the practical part was to find out the level of HPV awareness among girls and boys and diseases caused by HPV. The secondary aim of the practical part was to find out opinions on HPV vaccination and determine the rate of vaccination against HPV among young people in Slovakia. METHODS The method of quantitative research taken in the form of a questionnaire was used in the diploma thesis. The survey was realized at two secondary schools in Svidník, Slovakia. The age range of respondents was 15-20 years. The data...
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Analysis of Anticoagulant Utilization in the Czech Republic in the period from 2007 to 2016
Hochelová, Zuzana ; Zimčíková, Eva (advisor) ; Malý, Josef (referee)
Analysis of anticoagulant utilization in the Czech republic in the period from 2007 to 2016 Author: Zuzana Hochelová1 Supervisor: PharmDr. Eva Zimčíková, Ph.D.1 Consultant: PharmDr. Kateřina Malá, Ph.D.1 1 Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic Introduction: Anticoagulants are drugs that reduce blood clotting and prevent the formation of blood clots. In the Czech Republic - antagonists of vitamin K-warfarin, direct oral inhibitors of factor Xa-rivaroxaban, apixaban, edoxaban, direct oral inhibitors trombin - dabigatran, parenteral anticoagulants - heparin, low-molecular heparin, fondaparinux, oral and parenteral hirudin are used. Objective: The objective of this diploma thesis was to assess the consumption of oral and parenteral anticoagulants in the Czech Republic from 01. 01. 2007 to 31. 12. 2016, based on the data from the State Institute of Drug Control (SIDC). Methods: ATC/DDD methodology was applied. The research consisted of a retrospective analysis of the SIDC database. All oral and parental anticoagulants approved in the CR were included in the study. Drug utilization was calculated as number of defined daily doses per thousands of inhabitants per day (DID). The data on the number of residents was acquired from...
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Drug Information Centre service analysis I.
Chmelíková, Barbora ; Malá, Kateřina (advisor) ; Zimčíková, Eva (referee)
Drug Information Centre service analysis I. Author: Barbora Chmelíková Supervisor: PharmDr. Kateřina Malá, Ph.D. Consultant: PharmDr. Petra Thomson Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic Introduction and aim of the thesis This study deals with the analysis of enquiries of the Drug Information Centre (DIC) of Faculty of Pharmacy in Hradec Králové, Charles University and University Hospital Hradec Králové. DIC have a unique role within provide clinical- pharmaceutical care in the provision of drug information. The aim of this study was the analysis of drug enquiries in 1994-2016 focusing on their urgency, type of enquiries and ATC groups. Methods The data analysed were collected from all recorded enquiries in the Excel database within 1994-2016. Therefore, it was necessary to transform some of the paper- recorded enquiries from 1994 to 2002 into the Excel database in which the enquiries data from 2003 to 2016 were already included. Data analysis firstly focused on the characteristics of the enquiries (quantity, healthcare professionals' characteristics such as region, position, enquiry type and urgency of the enquiries). The character of enquiries included properties and active pharmaceutical ingredient of the medicines,...
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Analysis of Pharmacy Economy in the Hradec Králové Region
Švorcová, Nikol ; Kostřiba, Jan (advisor) ; Zimčíková, Eva (referee)
Charles University, Faculty of Pharmacy in Hradec Kralove Department of: Social and Clinical Pharmacy Author: Nikol Švorcová Supervisor: PharmDr. Jan Kostřiba, Ph.D. Title of Diploma Thesis: Analysis of Pharmacy Economy in the Hradec Kralove Region Introduction: The economy of pharmacies in the Czech republic is currently being discussed topic mainly due to the growth pharmacies belonging to chains. Within a few years there have been many highly discussed changes that have changed the pharmacy market and its character. Large companies, which operates a lot of pharmacies was established and these companies quickly increase number of their pharmacies. This has led to the emergence of so-called virtual chains, which help many private entrepreneurs in this area to maintain competitiveness. Between 2008 and 2015 was economy of pharmacies influenced by regulatory fees. The biggest problem of last years is the closure of pharmacies in smaller municipalities, which reduces the availability of pharmaceutical care. The Ministry of Health and the Czech Chamber of Pharmacists are finding a solution to these problems. Objectives: The aim of this diploma thesis is to evaluate the total financial health of selected pharmacies of the Hradec Kralove Region using methods of financial analysis based on a calculation...
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Analysis of prevalence of vitamin D deficiency in adults
Nováková, Jana ; Zimčíková, Eva (advisor) ; Pokladníková, Jitka (referee)
ANALYSIS OF PREVALENCE OF VITAMIN D DEFICIENCY IN ADULTS Author: Jana Nováková Supervisor: PharmDr. Eva Zimčíková, PhD. INTRODUCTION Estimated vitamin D deficiency occurs in up to 1/3 of the population. Vitamin D deficiency occurs in a number of diseases and in different countries of the world. AIMS The aim of the theoretical part of the diploma thesis was to get acquainted with vitamin D and its deficit in general. The objective of the practical part was to map vitamin D levels in adults, to assess prevalence of vitamin D deficiency, to determine if vitamin D levels fluctuate over the course of the year depending on age or gender and how they are related to individual illnesses. METHODS PubMed and Embase database search was performed to find evidence on vitamin D deficiency in adults. Only studies in humans, published in English in the period from 2000 to 2016 were included. Non-systematic review was provided, the quality of the studies was not evaluated. RESULTS Overall, 84 studies were included. Most of the studies enrolled healthy adults (n = 34). Among the studies concerning various diseases, musculoskeletal disorders were the most prevalent (n = 13). The highest prevalence of vitamin D deficiency was seen in the study from USA (in healthy adults) using cut-off value for deficiency ≤ 50...
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Evaluation of potentially inappropriate drugs and drug procedures in the old age (III.)
Pohořalá, Veronika ; Fialová, Daniela (advisor) ; Zimčíková, Eva (referee)
INTRODUCTION: The percentage of seniors in the population is increasing worldwide and Europe is not an exception in this case. Geriatric patients create a very specific group of patients in which the risk of drug-related problems is increased due to many reasons. Explicit criteria of potentially inappropriate medications/drug procedures (PIMs) in the aged belong to instruments helping with the evaluation of the quality of drug prescribing to older patients and have been developed in the past decades with the aim to increase the quality of geriatric pharmacotherapy and to minimize the quantity and severity of adverse drug reactions. The aim of this thesis is to evaluate the registration rates and OTC availability of pharmaceuticals from the PIMs list created for the purposes of EU COST Action IS1402 initiative (2015-2018) in 5 countries - Czech Republic, Estonia, Croatia, Poland and Slovakia. METHODOLOGY: Based on the thesis by S. Grešáková, MS, a list of 487 potentially inappropriate medicines/drug procedures in the aged has been created and subsequently also the record table stating the individual PIMs and other requested characteristics that was later filled by research teams of participating countries in the period from December 2016 to April 2017. In each country the following attributes were monitored:...
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Use of inhaled drugs in obstructive pulmonary diseases
Obertová, Nikola ; Malý, Josef (advisor) ; Zimčíková, Eva (referee)
Use of inhaled drugs in obstructive pulmonary diseases Author: Nikola Obertová 1 Tutor: Josef Malý 1 1 Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and objectives: Chronic respiratory diseases are emerging health problem. The administration of the medication is mostly performed by the process of inhalation. Therefore, a proper inhalation technique plays a crucial role in symptom reduction and achievement of adequate control over the disease. The aim of the thesis was partly to assess the level of inhalation technique in elderly patients in nursing home settings, partly to evaluate the knowledge of nurses and their role in advice provision related to the proper inhalation technique. Methods: The data were collected from June to September 2016 from 18 nursing homes located in South Wales (Great Britain). The study was realized in two arms. The evaluated group (first arm) was composed of patients (residents) with having asthma bronchiale or chronic obstructive pulmonary disease diagnosed and being older than 65 years. Second arm consisted of nurses responsible for giving advices about inhalation technique to the residents. Nursing home visits were composed of three parts. First one was a controlled interview based on the...
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Adherence to treatment in patients after kidney transplantation
Vaňková, Barbora ; Malý, Josef (advisor) ; Zimčíková, Eva (referee)
Adherence to Treatment in Patients after Kidney Transplantation Author: Barbora Vaňková Tutor: PharmDr. Josef Malý, Ph.D. Consultant: PharmDr. Kateřina Ládová, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and aims: Kidney transplantation (KT) is the best treatment option for patients with end- stage renal disease. However, despite its numerous benefits it requires a lifelong medical regimen of immunosuppressive treatment (IS) with a special emphasis on a strict medication adherence (MA). The objective of our study was to analyse MA in KT outpatients. We also intended to analyse non- adherence as one of the drug-related problems. Furthemore, we focused on analysis of the main self- management tasks. Methods: The prospective cross-sectional study was undertaken in one year period from March 2016 to March 2017 at the Haemodialysis Centre in the Teaching Hospital Hradec Králové. Patients ≥ 18 years old and at least 3 weeks after KT were addressed within their regularly scheduled visit to the nephrologist. Structured interview was performed by pharmacist to determine patients' self-reported MA to IS using validated Czech version of Medication Adherence Report Scale (MARS-CZ). In addition, patients were interviewed about other...
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Analysis of care in patients at risk for arterial hypertension in pharmacy III.
Smíšková, Petra ; Malý, Josef (advisor) ; Zimčíková, Eva (referee)
Analysis of care in patients at risk for arterial hypertension in pharmacy III. Author: Petra Smíšková Tutor: PharmDr. Josef Malý, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University in Prague Introduction: Arterial hypertension belongs to the most common diseases of cardiovascular system, not only in the Czech Republic. Therefore it is very important to focus on its prevention and early diagnostics before the stage of health complications shows up. Objectives: The aim of this thesis was to realize and evaluate consulting activities in pharmacy focused on patients who have high risks of arterial hypertension or have been already diagnosed with it. Methodology: Data were collected in a public pharmacy in Prague from the end of April 2013 until the beginning of April 2014. The actual blood pressure measurement was preceded by obtaining of answers to selected questions through controlled interview. Acquired statements were written into the printed forms. It was focused on particicipant's socio-demographic characteristics, his relationship to the blood pressure measurement; occurrence of risk factors of arterial hypertension, it means atherosclerosis; disease in the anamnesis and the usage of drugs including food supplements. The results of blood...
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Analysis of drug-related problems in ward health care facility I.
Nováková, Kateřina ; Malý, Josef (advisor) ; Zimčíková, Eva (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Candidate: Kateřina Nováková1 Tutor: Josef Malý1 1 Department of Social and Clinical Pharmacy, Charles University in Prague, Faculty of Pharmacy in Hradec Králové Title of Thesis: Analysis of drug-related problems in ward health care facility I. Indroduction: Use of drugs in clinical practice is accompanied by the risk of occurence of drug-related problems. Drug-related problems can have negative influence on patients health and the economic side of the treatment. Therefore their monitoring and elimination are needed as well as indicating and efforts to preventing. Objective: The aims of this thesis were to revise medical records, identify and classify potential drug-related problems, describe management of selected drug-related problems. Methods: The revision was carried out from 10th to 13th December 2013 in rehabilitation institute in the Czech Republic. Complete medical records of randomly selected patients were used as a source of information. All data were recorded into database prepared for the needs of revision. The revealed drug-related problems were then replenished into the database and in the same time they were classified according to PCNE modified classification V5.1 and...
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