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Analysis of spontaneous adverse events reports of antiepileptic drugs
Šoborová, Ivana ; Zimčíková, Eva (advisor) ; Malá, Kateřina (referee)
Analysis of spontaneous adverse events reports of antiepileptic drugs Author: Ivana Šoborová Supervisor: PharmDr. Eva Zimčíková, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction: Epilepsy is one of the most common neurological diseases, which occurs worldwide. Antiepileptic drugs (AED) suppress the onset of an epileptic seizure. Analysis of spontaneous adverse drug reactions (ADRs) analysis is important data source for generating the potential risks signals in pharmacotherapy. Objective: The aim of this work was to analyse spontaneous reports of ADRs from the Czech Central Database of ADRs of the State Institute for Drug Control (SÚKL) in the period from June 2004 to October 2017. The analyses of potential drug interactions of all medicinal products mentioned in the reports and the assessment of the reported ADRs expectability was the secondary goal. Methods: Retrospective analyses of the spontaneous ADR reports of antiepileptic drugs obtained from the SÚKL in the given period. Anonymized data was processed using the descriptive statistics in MS Excel. For example, the patient characteristics or seriousness and expectability of the ADRs were evaluated. The specific adverse drug reactions were divided according to the system...
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Analysis of pharmacotherapy in patients in the hospice
Sládek, Jakub ; Malý, Josef (advisor) ; Zimčíková, Eva (referee)
Analysis of pharmacoterapy hospice care patients Author: Jakub Sládek Tutor: doc. PharmDr. Josef Malý, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction and purpose: The therapy of hospice care patients is accompanied by many changes and pitfalls that need to be balanced when choosing appropriate therapy. In the teoretic part we can find available information about paliative therapy of hospice care patients, with emhasis on pain therapy. The aim of this thesis is the analysis of pharmacotherapy hospice care patients. Methods: The data were collected in a hospice from September 2019 to November 2019. The farmacotherapy was revised every first day of the month. Informations from personal, drug, family and occupational social history of patients were noted into an electronic database and, after revision, were classified and evaluated by frequency analysis. In four randomly selected patients was described the management of drug-related problems (DRP). Results: In total we noted medical therapy in 40 patients, women were 75 % of this number. Average patient's age was 72.4 years for men and 74.6 for women. Patients most often used drugs from group N (drugs of the nervous system) according to the ATC classification. We indentified 115...
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The Analysis of Senior's Opinions on Self-treatment by non-steroidal anti-inflamatory drugs
Kliui, Yuliia ; Doseděl, Martin (advisor) ; Zimčíková, Eva (referee)
Charles University, Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Candidate: Yuliia Kliui Consultant: PharmDr. Martin Doseděl PhD. Title of the diploma thesis: The Analysis of Senior's Opinions on Self-treatment by non- steroidal anti-inflammatory drugs Introduction: Due to their significant analgesic and antiphlogistic effects are non-steroidal anti-inflammatory drugs one of the most prescribed drugs. According to the high number of side effects and drug-drug interactions, it is important to pay attention to their presence in patient's medication. The importance of drug related problems increases in polymorbid and geriatric patients, who's medication can be altered by the presence of non-steroidal anti-inflammatory drugs, which can lead to unwanted complications. Aim of study: The principal aim of the theoretical part is to elaborate a review of the drug related problems concerning the side effects and drug-drug interactiond of NSAIDs. The practical part analyses via a question-study the senior's opinion and experiences on self- medication by analgesics focusing on ibuprofen. Methods: A cross sectional study have been conducted in the city of Kharkov in Ukraine. The data have been collected during an interview with a questionnaire. The used questionnairre has...
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Analysis of drug-related problems in a health facility IV.
Šubrtová, Linda ; Malý, Josef (advisor) ; Zimčíková, Eva (referee)
Analysis of drug-related problems in a health facility IV. Author: Linda Šubrtová Tutor: PharmDr. Josef Malý, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction: Increasing use of drugs leads to a growing risk of occurence of drug-related problems. These problems can often endanger patient's health and increase the economic cost of the treatment. However, many of these problems can be prevented by controls and collaboration of all health care subjects. Objective: The aim of this work was to carry out a revision of pharmacotherapy in a rehabilitation health facility and to analyse acquired drug-related problems. Methodology: The collection of data took place from 13 to 15 February 2017 in health facility in the Czech Republic. The review of pharmacotherapy was performed by a three-member team (clinical pharmacist, pharmacist, work researcher). The data obtained from the provided medical records were recorded into the database, which was prepared for the purpose of the pharmacotherapy review. Recorded were: the patient's age and sex, allergic, family, work, social and personal history, physical and laboratory examinations and complete pharmacotherapy, which included over-the-counter drugs and dietary supplements, including dosage...
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Attitudes and beliefs on HPV infection and vaccination III
Říhová, Andrea ; Zimčíková, Eva (advisor) ; Malá, Kateřina (referee)
Attitudes and beliefs on HPV infection and vaccination III Author: Andrea Říhová Consultant: PharmDr. Eva Zimčíková, Ph.D. Introduction Nearly 80% of world's population will get human papillomavirus (HPV) infection at some point of their lives. More than 99% cases of cervical cancer, which belongs to the second most common malignancy of women, is associated with HPV infection. The most reliable protection against this infection is vaccination. Aims The aim of the work was to find out knowledge of high school students about human papillomavirus and diseases caused by these viruses. In addition, find out the vaccine coverage rate against HPV and attitudes of students to this vaccination. Methods Data for this diploma thesis were obtained by survey, which took place at two high schools in the Usti Region in 2018. Overall, 291 questionnaires were used. Respondents were in age of 15-19. Data were processed by computer program Microsoft Excel. The t-test and Pearson's chi-squared test were used to statistically evaluate the data. Results Average age of the respondents was 17 years and 73.5% of respondents were women. Non- believers (93.5%) and non-smokers (92.4%) predominated among the respondents. Only one of the students did not know the concept of cervical cancer or penile cancer. More than half of...
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Analysis of the effect of pharmacotherapy on the risk of fall in inpatients III
Honsová, Tereza ; Malý, Josef (advisor) ; Zimčíková, Eva (referee)
Analysis of the effect of pharmacotherapy on the risk of falls in inpatents III Author: Tereza Honsová Tutor: PharmDr. Josef Malý, Ph.D. Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University Introduction: Falls are frequent and unwanted events happening in healthcare facilities. The falls have a multifactorial character. The prevention is the best way how to improve a quality of healthcare and a quality of the patient's life. All of the doctors, clinical pharmacists and nurses can help to realize it by cooperating with each other, working with professional information and by individual attitude to each patient. Objective: The aim of this study was to analyze the effect of the fall risk-increasing drugs to falls in hospitalized patients and to recommend the right interventions to prevent the fall. Methodology: For the analysation, classification and quantification of the fall risk-increasing drugs, drug related problems and interventions a special online database was created. All of the doctors, clinical pharmacists and nurses were collecting details about the pacients and about how the fall happened. Fall risk-increasing drugs and drug-related problems were then analyzed by clinical pharmacists. Potential interventions were suggested. Also other...
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Attitudes and beliefs on HPV infection and vaccination III
Říhová, Andrea ; Zimčíková, Eva (advisor) ; Malá, Kateřina (referee)
Attitudes and beliefs on HPV infection and vaccination III Author: Andrea Říhová Consultant: PharmDr. Eva Zimčíková, Ph.D. Introduction Nearly 80% of world's population will get human papillomavirus (HPV) infection at some point of their lives. More than 99% cases of cervical cancer, which belongs to the second most common malignancy of women, is associated with HPV infection. The most reliable protection against this infection is vaccination. Aims The aim of the work was to find out knowledge of high school students about human papillomavirus and diseases caused by these viruses. In addition, find out the vaccine coverage rate against HPV and attitudes of students to this vaccination. Methods Data for this diploma thesis were obtained by survey, which took place at two high schools in the Usti Region in 2018. Overall, 291 questionnaires were used. Respondents were in age of 15-19. Data were processed by computer program Microsoft Excel. The t-test and Pearson's chi-squared test were used to statistically evaluate the data. Results Average age of the respondents was 17 years and 73.5% of respondents were women. Non- believers (93.5%) and non-smokers (92.4%) predominated among the respondents. Only one of the students did not know the concept of cervical cancer or penile cancer. More than half of...
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Attitudes and beliefs on HPV infection and vaccination
Blašková, Dominika ; Zimčíková, Eva (advisor) ; Pokladníková, Jitka (referee)
ATTITUDES AND KNOWLEDGE OF HPV INFECTION AND VACCINATION Author: Dominika Blašková Supervisor: PharmDr. Eva Zimčíková, Ph.D. INTRODUCTION Human papillomavirus (HPV) is a DNA virus. The virus causes benign and malignant diseases of men and women such as laryngeal papillomatosis, genital warts, oropharyngeal carcinoma, cervical cancer, penile cancer and anus cancer. HPV can be prevented by appropriate precautionary measures. The main preventative method is vaccination against HPV. Besides vaccination, regular screening is necessary to detect premalignant changes on time. AIMS The aim of the theoretical part of the diploma thesis was to summarize the information about HPV, the diseases caused by human papillomavirus and vaccination against HPV, the main preventive measure. The primary aim of the practical part was to find out the level of HPV awareness among girls and boys and diseases caused by HPV. The secondary aim of the practical part was to find out opinions on HPV vaccination and determine the rate of vaccination against HPV among young people in Slovakia. METHODS The method of quantitative research taken in the form of a questionnaire was used in the diploma thesis. The survey was realized at two secondary schools in Svidník, Slovakia. The age range of respondents was 15-20 years. The data...
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Analysis of Anticoagulant Utilization in the Czech Republic in the period from 2007 to 2016
Hochelová, Zuzana ; Zimčíková, Eva (advisor) ; Malý, Josef (referee)
Analysis of anticoagulant utilization in the Czech republic in the period from 2007 to 2016 Author: Zuzana Hochelová1 Supervisor: PharmDr. Eva Zimčíková, Ph.D.1 Consultant: PharmDr. Kateřina Malá, Ph.D.1 1 Department of Social and Clinical Pharmacy, Faculty of Pharmacy in Hradec Králové, Charles University, Czech Republic Introduction: Anticoagulants are drugs that reduce blood clotting and prevent the formation of blood clots. In the Czech Republic - antagonists of vitamin K-warfarin, direct oral inhibitors of factor Xa-rivaroxaban, apixaban, edoxaban, direct oral inhibitors trombin - dabigatran, parenteral anticoagulants - heparin, low-molecular heparin, fondaparinux, oral and parenteral hirudin are used. Objective: The objective of this diploma thesis was to assess the consumption of oral and parenteral anticoagulants in the Czech Republic from 01. 01. 2007 to 31. 12. 2016, based on the data from the State Institute of Drug Control (SIDC). Methods: ATC/DDD methodology was applied. The research consisted of a retrospective analysis of the SIDC database. All oral and parental anticoagulants approved in the CR were included in the study. Drug utilization was calculated as number of defined daily doses per thousands of inhabitants per day (DID). The data on the number of residents was acquired from...
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Pharmacovigilance: Drug regulation development and legislation overview.
Manišová, Michaela ; Kostřiba, Jan (advisor) ; Zimčíková, Eva (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Social and Clinical Pharmacy Candidate Mgr. Michaela Manišová Consultant PharmDr. Jan Kostřiba, Ph.D. Title of Thesis Pharmacovigilance: Drug regulation development and legislation overview. Introduction: Pharmacovigilance is a scientific discipline relating to the detection and evaluation of adverse drug reactions and other risks associated with the use of the medicinal products after marketing authorisation and implementation of the risk minimisation measures. Objectives: To analyze the legislation requirements in the area of pharmacovigilance for the medicinal products for human use in the European Union and their implementation in practice. Trends in adverse drug reactions reporting in the various pharmacovigilance systems (United States, Czech Republic, European Union), evaluation of the factors affecting reporting and the main benefits of spontaneous reporting. Methods: The legal requirements of the European Union, the Czech Republic and the United States was used as the source of information, followed by the official website of the Drug Regulatory Authorities, the best practices guidelines prepared by the European Medicines Agency and by the Food and Drug Administration, the harmonization guidelines issued by...
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