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Comparison of efficiency of bibliographic databases for biochemical problems
Frantíková, Dagmar ; Hodek, Petr (referee) ; Hudeček, Jiří (advisor)
The study presents a comparison between four bibliographic databases widely used in biochemistry: paid SCOPUS and Web of Science and free-accessible MEDLINE and Google Scholar. Their efficacy and suitability for solving biochemical problems was evaluated. Three model problems were chosen and entered to databases: "ellipticine", "Lowry method" and "serine racemase". The located articles in each database were then sorted by their relevance. The best results were obtained with the SCOPUS database (highest proportion of relevant results; thus database has at the same time user-friendly interface). Very good was also free MEDLINE database and if paid databases are unavailable, MEDLINE would be the right option. The best results were found with a combination of both above named databases. Also database Web of Science gave good and relevant results but was not as useful as SCOPUS or MEDLINE. The worst results in this study was given by the database Google Scholar. It would be recommended for searches of basic, not so specific problems. This database locates many articles but with questionnable proportion of relevant articles - and these have to be found manually, which would be time-consuming. Thesis in Czech.
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The Role of Reductases in Cancer.
Škarydová, Lucie ; Wsól, Vladimír (advisor) ; Hodek, Petr (referee) ; Bílková, Zuzana (referee)
Only a small attention was paid for long time to reducing enzymes, but today it is clear that these are an important part of the endogenous metabolism and also the phase I biotransformation of xenobiotics. The significant group of reducing enzymes are carbonyl reductases that belong to two superfamilies - short chain dehydrogenases/reductases (SDR) and aldo-keto reductases (AKR). Their role in cancer is now intensively studied and their functions in cancer it is possible to divide into two main sections. It is known that carbonyl reductases play a substantial role in hormone-dependent cancers as prostate, breast or endometrial cancer. Active estrogens or androgens are important growth factors for these cancers because they evoke increasing of cell proliferation so that elevated possibility of mutations of important genes and development of cancer. Carbonyl reductases along with other enzymes (e.g. aromatase) participate in formation of these active sex hormones in extragonadal tissues, so an inhibition of such enzymes may be a target of anticancer therapy of hormone-dependent cancers. It is necessary to determine which enzymes are essential for the formation of active sex hormones in particular types of cancers. Besides hormone-dependent cancers, carbonyl reductases play also role in cancers that...
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