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Methods and Tools for Modelling of Multi-Comodity Markets
Janeček, Vítězslav ; Janoušek, Vladimír (referee) ; Hrubý, Martin (advisor)
This study investigates Game theory including economic theories related to agricultural production. Model creation simulating economical system is built upon theoretic starting points. Commodity production is simulated using game theory with searching for Nash equilibria. Commodity demand function is grounded on concept of Cournot game. System includes land trading based on sealed-bid auctions with second-price. This model is using external Gambit software which is freeware library for game theory computations. Model evaluation is located in Experiments section where model structure and truthfulness is tested.
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Social Networking for Questionnaire Survays
Huvar, Lukáš ; Zbořil, František (referee) ; Hrubý, Martin (advisor)
The aim of this work is to design and implement an application using an experimental library CloudKit. This application will serve as a social network for community submitters and questionnaire surveys respondents. Implemented social network is tested on a group of users who are involved in running the network. The benefit of this work is to test the Library CloudKit and its relevance for social networks.
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Modelling of Dynamic Games with Imperfect Information
Straka, Richard ; Smrčka, Aleš (referee) ; Hrubý, Martin (advisor)
This work concentrates on the study of dynamic games; in particular games with imperfect information, implementation of a model and experimentation with the model. The game DarkElf was chosen for this project. It is a strategic, turn based game with economic and military features, where the decisions made by players are simultaneously implemented at a predetermined time.
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Interactive Navigation through an User Database in Sqlite3
Vrtal, Petr ; Kočí, Radek (referee) ; Hrubý, Martin (advisor)
The aim of this thesis is to create a web application enhancing developer productivity, capable of interactive and intuitive browsing of a SQLite file database with a specified schema, representing user data. The enhancement is achieved specificaly by using a series of common views of this database and mechanisms for transition between these views. The web application is build using the Laravel PHP framework. User interface functionality is build mainly using Livewire framework by creating its interconnected components. An important part of the work was to determine by seeries of tests the level of resistence of the application against invalid user input as well as the speed analysis of the user's work with the application. The resulting web application allows a very specific group of users a clear orientation in the data of a specific production task, which is uploaded to the server by the users themselfs and the application offers them the option to view this data.
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PEGylated micelles for diagnostic and therapy against solid tumors
Hoang, Stéphane ; Hrubý, Martin (advisor) ; Frochot, Céline (referee) ; Bianco, Alberto (referee)
Title : PEGylated micelles for diagnostic and therapy against solid tumors. Keywords : micelles, ferrocene, photolysis, vectorization, nanoparticle, singlet oxygen Abstract : Nanomedicine is an emerging field that addresses the challenges faced by conventional medicine. The use of nanometric objects makes it possible to reduce side effects through targeted, specific treatment at reduced doses. Among these nanoparticles, micelles are widely exploited thanks to their small size and high modularity. As a result, their application extends to many fields, including oncology. Indeed, their size enables them to take full advantage of the characteristics of the tumor microenvironment, resulting in increased accumulation and retention of micelles in tumor tissue. Thus, the use of micelles as nanovectors offers a theranostic approach to cancer therapy. In this context, the work presented here is divided into two distinct parts. The first presents the synthesis and formulation of photodegradable PEGylated micelles capable of both generating cytotoxicity and delivering a hydrophobic molecule intracellularly. The second part focuses on the enhancement of the EPR effect by sonoporation, a method considered to be non-invasive. Results on murine models demonstrated the positive effect of this method by greatly improving...
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Perfluorinated and polyfluorinated substances in ski waxes
Hrubý, Martin ; Cajthaml, Tomáš (advisor) ; Semerád, Jaroslav (referee)
Perfluorinated and polyfluorinated compounds (PFAS) represent a group of thousands of anthropogenically produced substances. The strong bonding of carbon and fluorine gives these compounds unique properties, which have been used in ski waxes, among other applications. There is limited data on the specific PFAS used in wax production. This is due not only to the difficulty of analysis but also to the reluctance of manufacturers to disclose this information. The application of ski waxes has been associated with increased PFAS concentrations in the blood and some lung problems. Because of their persistence in ski areas, PFAS can be found in snow, soil, animals and plants. Although there is a gradual ban on the production and use of these substances, the issue of PFAS in ski waxes continues. This paper focuses on particular aspects of the issue. Key words: perfluorinated and polyfluorinated substances, PFAS, PFOA, ski waxes
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Synthesis of chelators for use in diagnostic imaging
Kretschmer, Jan ; Polášek, Miloslav (advisor) ; Kubíček, Vojtěch (referee) ; Hrubý, Martin (referee)
Metals play a crucial role in medicine as a part of therapeutic or diagnostic preparations. However, in the majority of cases, their properties cannot be utilized entirely in free ionic form. Organic molecules capable of chelation are used to open the full potential of the metal. The molecules are called chelators and are the core theme of this thesis. The most important function of these molecules is the chelation and coordination of the metal, but chelators can provide other important functionalities. This work, therefore, focuses on the design, synthesis, and application of such polyfunctional chelators and is divided into two parts: DO3A-Hyp This part of the thesis deals with chelators that can be used as amino acids to incorporate lanthanides into peptides. The developed chelators provide a short and rigid connection of the metal to the peptide chain. Tripeptides containing two units of such chelators with a central amino acid bearing a CF3 group were synthesized to demonstrate the capability of DO3A-Hyp building blocks. Two paramagnetic metals were combined within this tripeptide, and it was shown that such a rigid and locked system could be used for combining their magnetic susceptibility tensors. These magnetic susceptibility tensors were used for manipulation of the 19 F NMR shift of the CF3...
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Self-Assembled Polymer Systems Based on Poly[(N-2,2-difluoroethyl)acrylamide] as Diagnostic and Theranostic Tracers for 19F Magnetic Resonance Imaging
Kolouchová, Kristýna ; Hrubý, Martin (advisor) ; Matějíček, Pavel (referee) ; Poučková, Pavla (referee)
In this doctoral thesis we describe a series of stimuli-responsive polymers which could be used as diagnostic tools or as smart drug delivery systems with simultaneous diagnosis (theranostics). All hereby mentioned polymers are thermoresponsive copolymers of (N-2,2-difluoroethyl)acrylamide exhibiting lower critical solution temperature in aqueous milieu. This means that they are water-soluble at low temperature while when heated above a certain temperature, they self-assemble into nano- or macro- sized assemblies. Because of the high concentration of fluorine atoms, all these polymers could be used as 19 F MRI tracers. We designed multiple different thermoresponsive, thermo- and pH-responsive, thermo-and reactive-oxygen-species-responsive polymers that could find numerous discussed applications in human medicine. We investigated their physico-chemical properties with 1 H and 19 F nuclear magnetic resonance (NMR), size exclusion chromatography (SEC), elemental analysis, dynamic light scattering (DLS), static light scattering (SLS), small angle neutron scattering (SANS), small-angle X-ray scattering (SAXS), and turbidimetry. After the physicochemical optimization of the parameters for the selected applications, their biocompatibility was tested in vitro. Several promising polymers were tested in vivo...
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Lipid-based nanoparticles for the delivery of naphthoquinone derivatives for the treatment of psoriasis
Ulrichová, Tereza ; Hrubý, Martin (advisor) ; Poučková, Pavla (referee)
Psoriasis is an autoimmune chronic skin disease with a global prevalence of around 2-4%. Pharmacological treatment currently serves mainly to suppress the symptoms of the disease. However, many drugs have major side effects and therapy must often be discontinued. On the other hand, advances in understanding the pathophysiology of psoriasis have pointed out several molecular targets to be considered for future treatment. Traditional Chinese medicine has been using herbal extracts containing various types of 1,4-naphthoquinones for psoriasis treatment. These naphthoquinones have attracted much attention from the pharmaceutical industry for their structural diversity and wide range of pharmacological effects. Colored 1,4-naphthoquinones shikonin, juglon and their derivatives have already been tested on a numerous cell lines and animal models. The problem is their limited solubility in water, thermolability and susceptibility to oxidation and polymerization. Topical application is complicated by their strong binding to the upper layer of the skin, which causes skin discoloration that is difficult to wash off and reduces their penetration into the deeper layers of the skin, where their therapeutic effect is needed. To solve these problems, we developed within this thesis colorless prodrugs based on...
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iOS Client Interface for Production Scheduling System
Tomala, Tomáš ; Kočí, Radek (referee) ; Hrubý, Martin (advisor)
The aim of this bachelor thesis is to create mobile application for iOS operating system, which will serve as an interface to access PlannerLoop service. The PlannerLoop production scheduling system targets mainly smaller manufacturing companies that cannot afford to invest large sums in automated production scheduling tools. The client application of this service ensures the acquisition of the necessary user data, which it processes and sends to the computing server provided by the service. The user entered operations are scheduled by the service and placed by the client application on a timeline in the schedule, where it is possible to manipulate the operations.
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