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Vasculature models to study thrombolysis
Schildová, Veronika ; Ambrožová,, Gabriela (referee) ; Víteček, Jan (advisor)
The theoretical part of diploma thesis describes the cardiovascular system and focuses on hemostasis. This is a complex of events which maintain functional blood circulation. Hemostasis includes procoagulant processes responsible for elimination of bleeding as well as anticoagulant processes maintain blood fluidity. If there is an imbalance between procoagulation and anticoagulation, thromboembolic or bleeding diseases will occur. This work is focused on one of the most fatal diseases, ischemic stroke, and its treatment by thrombolytics. These are drugs that accelerate the degradation of the blood clot and the recanalization of the blood vessel. This thesis describes the comparison of the only thrombolytic approved for ischemic stroke – alteplase and its mutant tenecteplase. The experimental part is focused on various types of in vitro models to the study of thrombolysis. These are static model, microplate model, thrombus penetration into fibrin gel and sequestration. Such models are used to compare thrombolytics.
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In vitro study of thrombolytic resistance in ischemic stroke
Hložánková, Anna ; Raptová, Petra (referee) ; Víteček, Jan (advisor)
Ischemic stroke is one of the most common causes of mortality and permanent disability worldwide. The most frequently used therapeutic approach in stroke treatment is enzymatic thrombolysis using recombinant tissue plasminogen activator – alteplase. Although alteplase is currently the only clinically approved thrombolytic for the treatment of ischemic stroke, its efficacy is limited. These limitations can be caused by several factors, including the structure and mechanical properties of the clot. The theoretical part of this bachelor thesis is focused on ischemic stroke, its enzymatic therapy, and on the study of factors affecting thrombolytic efficacy. The practical part deals with in vitro preparation of structurally variable clots and the characterization of the effect of their structure on the efficacy of thrombolytic agents and the mechanical properties of clots.
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Case Study of Physiotherapeutic Treatment of a Patient after Ischemic Stroke with Right Hemiparesis
Pacltová, Kateřina ; Stupková, Michaela (advisor) ; Nováková, Tereza (referee)
v Abstract Title: Case study of physical therapy treatment of a patient after ischemic stroke with right hemiparesis Objective: The aim of my bachelor thesis is to provide a comprehensive theoretical overview of ischemic stroke and to present a case study of physiotherapeutic care for a specific patient with this diagnosis in the special section. Method: This thesis comprises a theoretical part and a special part. The theoretical section focuses on compiling knowledge about ischemic stroke using scholarly literature and current resources. The special part addresses a case study of physiotherapeutic care for a specific patient who has suffered an ischemic stroke. It includes anamnesis, initial kinesiological analysis, short term and long term physiotherapeutic plans, daily records of therapies, and final kinesiological analysis, as well as an assessment of the therapeutic outcomes. Results: Based on theoretical foundations, physiotherapeutic care was applied, which led to an improvement in self-sufficiency, increased muscle strength, enhanced stability, greater range of motion, and reduced pain in the shoulder joint. Conclusion: The goals of the bachelor's thesis were achieved, a comprehensive overview of the aspects of ischemic strokes was provided, and a case study of physiotherapeutic care for a patient...
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A case report of physiotherapeutic care of a patient after stroke with left-sided hemiparesis
Kmochová, Natálie ; Neuwirthová, Svatava (advisor) ; Dědková, Miriama (referee)
Title: A case report of physiotherapeutic care of a patient after stroke with left-sided hemiparesis Objectives: The aim of the bachelor thesis is to elaborate the theoretical knowledge dealing with stroke and the practical part including a case study of a patient after stroke with left-sided hemiparesis Summary: The bachelor thesis was created on the basis of a four-week continuous internship at the Hospital Milosrdných sester sv. Karla Boromejského in Prague, in the rehabilitation department from 22 January 2024, to 16 February 2024. The thesis is divided into a theoretical part, dealing with cerebrovascular accident, and a practical part containing the methodology of work and a case study of a patient with this diagnosis. In the theoretical part, I focused on the characteristics of cerebrovascular accident and physiotherapeutic procedures. The patient's case study includes the initial examination, 8 therapeutic sessions, and a final follow-up examination including an overall conclusion. Keywords: CMP, stroke, ischemic stroke, ischemic stroke with left-sided hemiparesis, rehabilitation after ischemic stroke
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Case study of physiotherapy treatment of a patient after ischemic stroke in basal ganglia with right sided spastic hemiparesis
Barakat, Husam Aldin Naser ; Kočí, Gabriela (advisor) ; Vomáčková, Helena (referee)
Název: Případová studie fyzioterapeutické léčby pacienta po ischemické cévní mozkové příhodě v bazálních gangliích s postižením pravé strany těla v podobě spastické hemiparézy Cíl: Tato práce si klade za cíl zkonsolidovat teoretické poznatky o ischemické cévní mozkové příhodě a představit podrobnou kazuistiku pacienta trpícího postižením pravé strany těla v důsledku ischemické cévní mozkové příhody v bazálních gangliích. Metody: Tato bakalářská práce je rozdělena do dvou hlavních částí: obecné a specifické. Obecná část komplexně pokrývá teoretické aspekty související s cévní mozkovou příhodou, zahrnující typická fyzioterapeutická vyšetření pro diagnostiku, spolu s výběrem běžně používaných metod a postupů ve fyzioterapeutickém řízení těchto pacientů. Specifická část se zabývá kazuistikou pacienta po ischemické cévní mozkové příhodě, zaměřuje se na následné postižení pravé strany těla v podobě hemiparézy. Zahrnuje podrobné popisy počátečního a finálního kineziologického vyšetření, průběh jednotlivých terapií a komplexní shrnutí výsledků terapie. Specializovaný obsah vychází z praktických zkušeností získaných během kontinuální profesionální praxe na Oddělení pooperační rehabilitace v Oblastní nemocnici Kladno, probíhající pod vedením supervizora Bc. Tomáše Modlingera od 16. ledna do 10. února 2023....
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A case report of physiotherapeutic care of a patient after ischemic stroke
Kozerawska, Natália ; Sohrová, Jana (advisor) ; Křížková, Štěpánka (referee)
Title: A case report of physiotherapeutic care of a patient after ischemic stroke Objective: The aim of this thesis is to summarize the theoretical information on the topic of stroke and then to develop a case report of a patient after ischemic stroke with right-sided hemiparesis. Methods: This bachelor thesis deals with stroke and is divided into two parts - general and special. The general part contains the main theoretical information about stroke. In addition, the physiotherapist's examination typical of the diagnosis is described, together with a selection of methods and procedures most commonly used in the physiotherapeutic care of these patients. The special section includes a case report of a patient after ischemic stroke with subsequent right-sided hemiparesis, including the initial and final kinesiological examination, the course of individual therapies and a summary of the effect of therapy. The background for the special part was obtained during the continuous professional practice at the Department of Post- operative Rehabilitation at the Regional Hospital Kladno from 9 January to 3 February 2023 under the supervision of the supervisor Mgr. Dita Hamouzová. Results: The patient improved in several aspects, especially in overall stability and range of active motion. However, there was...
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CMP (STROKE) - ALGORITHM OF EXAMINATION METHODS
MACKOVÁ, Pavlína
The bachelor thesis on CMP (stroke) - algorithm of examination methods deals with the disease of stroke, its definition, methods of examination, possible treatment and students' knowledge about this disease. The main objective of this study was to learn about the algorithm of examination methods in stroke and to find out the awareness of the respondents about this topic. The research question was: What is the awareness of the respondents about the process of examination and diagnosis of CMP? The thesis is divided into a theoretical section and a practical section. The first part focuses on the current state. Here the vascular supply to the brain, stroke, algorithm of examination methods and treatment of stroke are covered. Overall, the thesis is divided into six main chapters. The practical part deals with the questionnaire survey. The research purpose of this thesis was fulfilled by means of a questionnaire survey among Radiology Assisting students and Public Protection students with a focus on CBRNE. The questionnaire developed was the same for both groups of students. It was a standardized questionnaire with a choice of one answer each time. The resulting answers were then evaluated in clear graphs. The results of the conducted survey can offer us students' perspectives on anatomical knowledge of the brain, basic information about stroke, selected types of stroke examinations and stroke treatment. In addition, results from Radiology Assisting students and results from Public Protection students with a CBRNE focus can be compared to each other. The results can show us where students make the most mistakes and what information they know instead. Thus, the work can serve as a study material for students of all medical disciplines.
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Prognosis in Ischemic Stroke Patients and Related Prognostic Faktors
Kielbergerová, Lenka ; Rohan, Vladimír (advisor) ; Holečková, Irena (referee) ; Petrák, Ondřej (referee)
Stroke is a significant cause of morbidity and mortality in the developed world. In the theoretical part of the thesis, we try to summarize the overall knowledge of stroke, the definitions and the general approach to the diagnosis and treatment, with a focus on ischemic stroke. Furthermore, the issue of acute phase treatment and secondary preventive treatment of ischemic stroke is reviewed and the modalities of the subsequent neurological deficit evaluation, the occurrence of mood disorders and the assessment of the quality of life of individuals after stroke are discussed. Our research aimed to assess the perspective of ischemic stroke patients admitted to the hospital. The first part is focusing on the mortality of patients with ischemic stroke in the period 2003-2019 in the Westbohemian region and its relation to secondary prevention. The second part aims to identify the main clinical and psychosocial factors affecting the quality of life of chronic stable post-stroke patients after their first in-life episode of stroke. The relation of poor quality of life indicators, mortality and conventional cardiovascular risk factors is prospectively assessed. The mortality of patients after first-in-life ischemic stroke hospitalization the years 2003- 2019 is higher compared to worldwide trends. In the...
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Case study of physiotherapeutic treatment of a patient after ischemic stroke
Stupková, Petra ; Reckziegelová, Petra (advisor) ; Nováková, Tereza (referee)
Title: Case study of physiotherapeutic treatment of a patient after ischemic stroke Aims: The aim of this bachelor thesis is to characterize the disease of stroke in the theoretical part and in the practical part to elaborate a case report of a patient with this diagnosis. Methods: The processed case report consists of anamnesis, initial kinesiological analysis, short-term and long-term therapeutic plan, daily therapy record of ten therapeutic units, final kinesiological analysis and evaluation of the effect of therapy. Results: The evaluation of the effect of therapy shows that there has been a significant improvement or overall elimination of most of the patient's functional and motor deficits. Keywords: Stroke, ischemic stroke, left hemiparesis, rehabilitation, physiotherapeutic treatment of a patient after ischemic stroke
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Case study of physiotherapy treatment in a patient after an ischemic stroke with left spastic hemiparesis
Pakandlová, Kateřina ; Chroustová, Kristina (advisor) ; Hořejší, Jan (referee)
Author: Kateřina Pakandlová Title: Case study of physiotherapy treatment in a patient after an ischemic stroke with left spastic hemiparesis. Objectives: The purpose of this bachelor thesis is to find out theoretical information about stroke and to process a case study about physiotherapeutic care in a patient after an ischemic stroke. Methods: The thesis is divided into two parts, including a theoretical part and a special part. The theoretical part is specialized in obtaining and processing information about stroke - its clinical symptoms, risk factors, diagnosis, medical treatment, and physiotherapeutic care. The special part involves a case study of physiotherapeutic care in the chosen patient who suffered an ischemic stroke. It consists of an initial and a final examination, therapeutic plan, therapy sessions, and evaluation of the effect of therapy. The case study comes from my practical experience at the Vršovická Zdravotní a.s. during January and February 2022. Results: The patient's strength and range of motion in the left limbs had increased, and self- support had improved. The patient returned home. Keywords: stroke, ischemic stroke, left-sided hemiparesis, rehabilitation
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