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Influence of different types and ratios of microcrystalline cellulose and lactose on physical properties of tablet blends and tablets.
Machutková, Hana ; Šklubalová, Zdeňka (advisor) ; Ondrejček, Pavel (referee)
1 Abstract Charles University in Prague, Faculty of Pharmacy in Hradci Králové Department of: Departmanet of Pharmaceutical technology Consultant: doc. PharmDr. Zdeňka Šklubalová Ph.D. Student: Hana Machutková Title of Thesis: Influence of different types and ratios of microcrystalline cellulose and lactose on physical properties of tablet blends and tablets. In this study, the properties of tablet blends prepared from five different kinds of microcrystalline cellulose (Avicel ® A-101, 102, 105, 112, 200) and three types of lactose in different proportions were evaluated. Moisture content, the bulk and tapped density and the angle of repose were compared for tablet blends. The addition of lactose to the mixtures caused the decrease in the moisture content in the tablet blends. After evaluating the flow properties, the mixtures with suitable characteristics were compacted at compression forces of 8 and 12 kN. The force required to eject the tablet, the table strength, the disintegration time and the friability of the resulting tablets were estimated. The worst compressibility was identified for mixtures with higher concentration of Avicel 105. Due to its very small and fine particles (approximately 20μm) the filling of matrix was not uniform making tablet compression unsuccessful and thus the of uniform...
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Evaluation of elastic recovery of tablets containing theophylline
Vitverová, Barbora ; Šklubalová, Zdeňka (advisor) ; Ondrejček, Pavel (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Consultant: Doc. PharmDr. Šklubalová Zdeňka, Ph.D. Student: Barbora Vitverová Title of Thesis: Evaluation of elastic recovery of tablets containing theophylline This diploma thesis deals with evaluation of elastic recovery of tablets containing theophylline. The axial and radial elastic recovery is evaluated. Used materials are characterized in a theoretical part. It concerns microcrystalline cellulose Comprecel 102, lactose SpheroLac 100, calcii hydrogenphosphas anhydrous Di- Cafos A150, calcii hydrogenphosphas dihydrate Di-Cafos D160, magnesii stearas and theophylline. Further, compression process and its evaluation are described and also the elastic recovery of tablets after compression, its calculation and factors which can influence it. The experimental part of thesis deals with the elastic recovery of tablets. The tablets were compressed by compression strength 10 kN and the height and diameter were measured after 0, 3, 6 and 24 hours after compressing. The elastic recovery of tablets was calculated from these values. The dimensions of tablets at the maximal compression strength 10 kN were used as the initial values. From results is obvious that the highest elastic recovery is...
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Measurement of stress relaxation of mixtures of microcrystalline cellulose and calcium hydrogen phosphate intended for the preparation of tablets with theophylline
Hofmanová, Markéta ; Šklubalová, Zdeňka (advisor) ; Ondrejček, Pavel (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical technology Consultant: Doc. PharmDr. Sklubalova Zdenka, Ph.D. Student: Marketa Hofmanova Title of Thesis: Measurement of stress relaxation of mixtures of microcrystalline cellulose and calcium hydrogen phosphate intended for the preparation of tablets with theophylline The powder mixtures with theophylline were studied from the aspect of viscoelastic properties of used materials and tablets tensile strength. In the theoretical part the thesis concerned with description of materials which were used in the mixtures. They are: Microcrystalline cellulose Comprecel 102, calcium hydrogen phosphate anhydrate Di-Cafos A150, calcium hydrogen phosphate dihydrate Di-Cafos D160 and lactose SpheroLac 100. The thesis also deals with the stress relaxation test. The stress relaxation test, its evaluation by several methods and its use in the pharmacy and in different fields are described. The experimental part deals with viscoelastic characteristics of the mixtures. These characteristics were evaluated by stress relaxation test with maximal compression force 10 kN and dwell time 180 s. Also the tensile strength was evaluated. The highest values of parameters of elasticity A1-3 and plasticity P1-3 were measured in...
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Determination of flow properties of mixtures for preparation of tablets containing theophylline
Brunettová, Monika ; Šklubalová, Zdeňka (advisor) ; Mužíková, Jitka (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Consultant: Doc. PharmDr. Šklubalová Zdeňka, Ph.D. Student: Brunettová Monika Title of Thesis: Determination of flow properties of mixtures for preparation of tablets containing theophylline The aim of this diploma thesis was to characterize the flow properties and moisture content of mixtures for preparation of tablets containing theophylline. Parameters were monitored depending mainly on the content of the fillers, that were dicalcium phosphate, microcrystalline cellulose and lactose. Twenty-five prepared mixtures with different ratios of these fillers were evaluated. Flowability was evaluated by three methods stated in Czech Pharmacopoeia 2009 - compressibility index and Hausner ratio, flow through an orifice and angle of repose. Moisture content was evaluated as a weight loss during drying. Mixtures containing dicalcium phosphate and lactose proved more appropriate in terms of flowability, their flow properties are passable. However, according to the moisture content, mixture with microcrystalline cellulose are more preferable.
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Gramification and its practical applications through the use of tablets in the context of school education
Manas, Adele ; Wolák, Radim (advisor) ; Švelch, Jaroslav (referee)
This thesis examines the use of gamification principles in education, specifically where tablets are being used in the classroom. Individual chapters deal with explaining the concepts related to gamification, educational games and the specifics of implementing tablets into education. Their specific usage was examined through conversations with the teachers and students of Year 2 of a primary school, with the results being recorded in the research section. Research questions examined the theoretical concepts introduced in the first part of the thesis and centred around the theme of education via tablets. The types of tablet applications used were also investigated. When possible this thesis compares the views of teachers and students on the areas examined.
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Determination of the compressibility of excipients used for formulation of tablets with theophylline.
Kousoulidou, Viktoria ; Šklubalová, Zdeňka (advisor) ; Ondrejček, Pavel (referee)
1 Abstract Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Consultant: Assoc. Prof. PharmDr. Zdenka Sklubalova, Ph.D. Student: Viktoria Kousoulidou Title of Thesis: Determination of the compressibility of excipients used for formulation of tablets with theophylline The current thesis is focused on the compressibility properties of five powders used in tablet formulation: Comprecel, Spherolac, DI-CAFOS D160, DI-CAFOS A150 as excipients and Theophylline as the active substance. The particle size, moisture content, bulk density and flowability of the powders are determined. The powders are compressed and the results are evaluated by means of the parameters of the compaction equation and the force-displacement method (compression under 5, 10, 15 kN). Then, the crushing strength of tablets prepared from each powder by the force-displacement method is measured. The average values of the crushing strength are used to calculate the tensile strength of the tablets. Best compressibility is found in Comprecel and Theophylline with tensile strength values of 1.31 MPa under 5 kN, 3.31 MPa under 10 kN, 4.75 MPa under 15 kN and 1.02 MPa under 5 kN, 2.27 MPa under 10 kN, 3.09 MPa under 15 kN, respectively.
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Evaluation of compressibility of tableting mixtures containing theophylline using a compaction equation
Matyášová, Andrea ; Šklubalová, Zdeňka (advisor) ; Svačinová, Petra (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department: Department of Pharmaceutical Technology Consultant: Doc. PharmDr. Zdeňka Šklubalová, Ph.D. Student: Andrea Matyášová Title of Thesis: Evaluation of compressibility of tableting mixtures containing theophylline using a compaction equation This thesis is aimed at the evaluation and comparison of excipients used in production of tablets. The compaction process of these excipients was evaluated using the parameters of the compaction equation. The mixtures of four fillers in various ratios were evaluated. These mixtures contained also theophylline as model drug and magnesium stearate as lubricant. The used three-exponential equation was previously developed by doc. RNDr. Milan Řehula, CSc. By using this compaction equation the volume reductions, speeds of volume reductions and consumed energies were calculated and evaluated. The results of this work showed that particular used fillers have different effect on the compaction process flow. That is caused primarily by different behavior of these materials during compaction and by formation of different types of bonds. Also the need of thorough cleaning and drying of compaction aid before compaction was confirmed.
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Evaluation of tensile strength of tablets containing theophylline
Janoutová, Hana ; Šklubalová, Zdeňka (advisor) ; Ondrejček, Pavel (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Technology Consultant: Doc. PharmDr. Zdeňka Šklubalová, Ph.D. Student: Hana Janoutová Title of Thesis: Evaluation of tensile strength of tablets containing theophylline The aim of this thesis was to determine tensile strength of tablets containing theophylline. Tensile strength was studied as a function of the composition of mixtures of the used fillers and especially on their ratio. In the theoretical part, the used materials - lactose SpheroLac 100, microcrystalline cellulose Comprecel 102, dibasic calcium phosphate dihydrate Di-Cafos D160, anhydrous dibasic calcium phosphate Di-Cafos A150, theophylline and magnesium stearate are described. This work also evaluates force-displacement record, tensile strength and various factors that affect tensile strength. Parameters of force-displacement record and tensile strength of the tablets compressed with compresssion force 10 kN were evaluated in the experimental part. The measured results show that higher values of precompression energy (E1) and energy of plastic deformation (E2) were detected in mixtures A, C and E which contain Comprecel 102, and the lowest values were detected in mixtures B which contain Sphero-Lac 100 and Di-Cafos D160. Values of energy...
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Evaluation of disintegration time of tablets containing theophylline
Brtnová, Soňa ; Šklubalová, Zdeňka (advisor) ; Mužíková, Jitka (referee)
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of: Pharmaceutical Technology Thesis supervisor: Doc. PharmDr. Zdeňka Šklubalová, Ph.D. Consultant: Mgr. Pavel Ondrejček Student: Soňa Brtnová Title of Thesis: Evaluation of disintegration time of tablets containing theophylline The influence of used fillers on energetic profile of compression, especially influence on disintegration time of tablets with theophylline as a model drug, was studied in this thesis. Four tablet fillers were studied - microcrystalline cellulose Comprecel 102, lactose SpheroLac 100, calcium hydrogen phosphate anhydrous Di- Cafos A150 and calcium hydrogen phosphate dihydrate Di-Cafos D160. Tablets contained different proportion of two fillers, theophylline as a model drug and lubricant magnesium stearate. Tablets were compressed by the same compaction force 10 kN. The force- displacement record was evaluated using the particular energies of compaction process. Parameters of compaction process were influenced mostly by Comprecel 102. According to results there is no possibility to replace Di-Cafos D160 with Di-Cafos A150 in the mixtures. It was also found that SpheroLac 100 and Di-Cafos D160 shows similar behavior. Time of disintegration of tablets is mostly dependent on the used fillers. Tablets...
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Effect of paracetamol on the parameters of compression equation
Mařanová, Lucie ; Řehula, Milan (advisor) ; Ondrejček, Pavel (referee)
Evaluation of the tableting mixtures containing the paracetamolum by the parameters of the equation of compression The diploma thesis deals with effect of paracetamol on the parameters of compression equation. These parameters characterize compression process in the individual phases of compression: precompression phase, phase of elastic deformation and phase of plastic deformation. Paracetamolum was studied in the five mixtures, where it occurred in different ratio with microcrystalline cellulose. Looseness, Carr's index and Hausner ratio were evaluated for each mixture. The sizes of reductions ai, sizes of energies Ei and Ri, "half-pressures" pHi and the velocity constants 1/ti were calculated using three-exponential equation of compression for the individual phases of pressing. The results showed poor flow properties of tableting mixtures and thus its unsuitability for direct compression. The results of the study have revealed that increasing amounts of paracetamolum in the mixture increase reduction of volume a1 and velocity of volume change 1/t1 in dependence on the amount of the extruded air and decrease the required energy due to the smooth surface and less friction during the precompression phase. Reduction of volume a2 decrease with the increase of content of paracetamol due to...
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