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Xanthone-boronic acids: An insight into the synthesis of borylated xanthone derivates
Houngbedji, Priam-Amedeo ; Doležal, Martin (advisor) ; Zitko, Jan (referee)
CHARLES UNIVERSITY FACULTY OF PHARMACY IN HRADEC KRÁLOVÉ DEPARTMENT OF PHARMACEUTICAL CHEMISTRY AND PHARMACEUTICAL ANALYSIS DIPLOMA THESIS XANTHONE-BORONIC ACIDS: AN INSIGHT INTO THE SYNTHESIS OF BORYLATED XANTHONE DERIVATIVES Supervisor: prof. PharmDr. Martin Doležal, Ph.D. HRADEC KRÁLOVÉ 2021 PRIAM-AMEDEO HOUNGBEDJI Abstract - English The development of Bortezomib 5 and discovery of its potential in the treatment of multiple myeloma has sparked hope, and a close attention is paid in medicinal chemistry to the synthesis of boronic acid derivatives as well as the evaluation of their anticancer, antimicrobial, and other activities. Parallelly, xanthones and xanthone derivatives are compounds thoroughly studied for their potential in the treatment of cancer, and their good antimicrobial, anti-inflammatory, antiviral and anticonvulsant activity. It is only natural that efforts are oriented towards the synthesis of xanthone boronic derivatives. 3,6-Dihydroxyxanthone 10 was chosen as a precursor for the development of a procedure to borylate xanthones, mainly due to its easy synthesis and availability. From 10, 3,6-ditrifylxanthone 11 was easily prepared. The synthesis of 3,6- bis(pinacolatoboron)xanthone 8 from 11 was achieved using bis(pinacolatodiboron) B2pin2 as a borylation agent under Pd(dppf)Cl2 catalysis...
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Flood monitoring using satellite radar data for different land cover categories
Rauch, Tomáš ; Kolář, Jan (advisor) ; Brodský, Lukáš (referee)
The aim of this thesis is to find method for flood monitoring from radar images. The thesis deals with flood in general and with organization of flood protection. There are described principles of radar sensors. There is also summary of satellites with their parameters. Next part of the thesis describes interaction between radar beam and different types of surface. Theoretical part is closed by overview of the existing methods for flood monitoring. In the practical part there is method for flood monitoring applied to areas affected by flood. The process is based on the classification of the radar image. Using classification and digital elevation model is drawn boundary of flooded area. The result boundaries are compared with the existing maximal flooded areas.
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Pyrazine Derivatives as Potential Antituberculosis Drugs II.
Tauchman, Marek ; Doležal, Martin (advisor) ; Kopecký, Kamil (referee)
Charles Univeristy in Prague, Faculty of Pharmacy in Hradec Králové Department Department of Pharmaceutical Chemistry and Drug Control Author: Marek Tauchman Supervisor: Prof. PharmDr. Martin Doležal, Ph.D. Title of Diploma Thesis: Pyrazine Derivatives as Potential Antituberculosis Drugs II. Tuberculosis still presents serious worldwide problem of today. The situation is complicated especially by increasing proportion of strains resistant to common antituberculotics. Therefore the need of a new compound active against mycobacterial causer of the disease is very actual. Synthesis of compounds derived from pyrazinamide, very effecitve anti-mycobacterial substance, is one of the perspective way of new drugs development. Department of Pharmaceutical Chemistry and Drug Control, Faculty of Pharmacy in Hradec Králové, beside others, deals with this problem in a long term. There were synthesized hundreds of compounds containing pyrazine core and they were tested to antimycobacterial activity. The target of this thesis is join this effort and contribute to increase the number of compound that has been studied for antituberculosis activity. At the beginning of thesis, there is a summary of facts about tuberculosis, such as incidence, patogenesis and cure. Next, there are informations about newly developed...
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Using Sentinel-1 data for creating a digital terrain model by means of radar interferometry
Karvánek, Matouš ; Potůčková, Markéta (advisor) ; Hlaváčová, Ivana (referee)
Using of Sentinel-1 data for radar interferometry Abstract The diploma thesis deals with extraction of a digital surface model (DSM) using synthetic aperture radar interferometry (InSAR) and Sentinel-1 data in selected locations of the Czech Republic. The InSAR technique, the Sentinel-1 data, their parameters and possibilities of their usage are described in the theoretical part of the thesis. The specification of the model areas and used data follows. The practical part is focused on creating a methodology of deriving a digital surface model and its extracting in the three tested locations. These locations differ from each other in their geomorphological features and land cover. At the end of this part the comparison of the extracted model with the reference model DMP 1G using statistical methods is carried out. At the end of this thesis the results are evaluated and discussed. Key words: InSAR, Sentinel-1, SAR, DSM
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Air rescue service
Plná, Kateřina ; Fiala, Miloš (advisor) ; Vilášek, Josef (referee)
Title of project: Use of air ambulance service in the mountain Aim of project: The aim of this work is to introduce the history and present use air ambulance services in the mountain. Methods of project: Because this is a theoretical work, the collection method used data from available literature, Internet resources, guidelines and regulations. Results: The result will be a chronological summary of all existential Important milestones in the functioning of aviation ambulance service in the mountain. Key words: Rescue, Aviation, First Aid, Christopher, SAR
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Money Laundering and Suspicious Activity Reporting in the United States
Krouparová, Ivana ; Janský, Petr (advisor) ; Mišák, Vojtěch (referee)
Money laundering is a seriously understudied phenomenon and despite the continuous advancement of detecting technology, continues to be a serious issue today. This thesis provides a detailed definition of money laundering, lists some of the most common examples of how this illegal activity can be carried out in practice, and provides a brief historical overview of the U.S. efforts to combat it. The next segments follow up on previous research in order to evaluate the effectiveness of the U.S. suspicious activity reporting (SAR) system. The paper investigates whether an elevated prevalence of certain offenses, such as financial crime or drug trafficking, could explain the growing number of SARs or if the upward trend could be in part explained by institutions over-reporting in fear of the penalties set by the local regime. The estimates obtained by applying the random effects model on a panel of 51 U.S. states, including the District of Columbia, did not indicate a presence of excessive over-reporting. Instead, the regression results showed a negative correlation between the SAR filing rate and the prevalence of financial crime in the state. A conclusion is drawn that the increasing number of SARs cannot be viewed as a result of more financial crime, implying that systematic under-reporting may be...
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Evolution of silica structures in SAR protists
Čížková, Natálie ; Čertnerová, Dora (advisor) ; Kulichová, Jana (referee)
Silicon is an important element in the earth's crust. In nature it mainly occurs in the form of silicic acid. This element is used by marine and freshwater organisms to form their siliceous structures. The organisms that make up these structures are located throughout the phylogenetic tree and are not limited just to protist groups. The SAR line includes Stramenopila, Alveolata and Rhizaria. The main protist taxa forming the mentioned siliceous structures are in these groups. These are mainly diatoms, silicoflagellates, radiolarians and the group chrysophyceae. The formation of siliceous structures usually provides evolutionary benefits to organisms, such as protection of the cell from actions of biotic and abiotic factors. The availability of dissolved silicon changed during evolution, thus affecting the appearance and functionality of the structures of individual species. Structural changes were manifested by thinning of the shells, change of cell size, enlargement or decrease of pores, increase of the number of thorns or, conversely, their loss. The individual lines thus had to choose the best possible strategies in response to the decreasing availability of silicic acid. Therefore, there was frequent competition between the groups for the remaining dissolved silicon. The current diversity of...
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Grassland management monitoring based on Sentinel-1 data
Doležal, Jan ; Potůčková, Markéta (advisor) ; Brodský, Lukáš (referee)
The main goal of this diploma thesis was to find and quantify the connection between coherence, entropy, polarimetric angle alpha obtained from Sentinel-1 radar data and grass cutting/pastures. The research was carried out in the area of the Krkonoše national park. To assemble and validate applied methodology, field data was collected 5 times. Hourly rainfall data from Czech hydrometeorological institute was available, but it did not have to be used - no rainfalls were recorded at the time of data acquisitions. Dependence between mowing and the value of coherence has been confirmed. After mowing, median coherence was higher than before mowing. The results were similar to VH as well as VV polarization. Coherence on polygons remained higher after 12-24 days. In total, two different data acquisition geometries (ascending and descending) were examined. The results in both cases were similar. For polarimetric parameters, no correlation between polarimetric parameters and grass mowing or pasture has been confirmed. Keywords: radar, SAR, Sentinel-1, coherence, polarimetry, grass mowing
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Elektromagnetic field mapping in tissue
Port, Martin ; Čížek, Martin (referee) ; Rozman, Jiří (advisor)
This thesis is an introduction to the modeling of electromagnetic fields in the tissue and is focused on the knowledge of electromagnetic field theory. Maxwell's equations and their solutions are described the spread of plane waves in the environment. It also discusses the exposure limit values of specific absorbed power and hygienic limits based on the standards in force in the Czech Republic on health protection against nonionizing radiation in accordance with Government Regulation No. 106/2010 Coll. It also deals with the software interface in COMSOL Multiphysics 4.2 for solving physical modeling and simulation. There is mention of the RF module, which is used for modeling. Work mentions in detail about the menu of the program and the most important part - the Model Builder.
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Soil moisture estimation using Sentinel-1 radar data
Outrata, David ; Štych, Přemysl (advisor) ; Potůčková, Markéta (referee)
Soil moisture estimation using Sentinel-1 radar data The main aim of this diploma thesis was to find and quantify the relationship between the intensity of backscatter from the Sentinel-1 radar data and the volume soil moisture at the level of agricultural fields. The research was conducted in three areas, in the first part there were two vegetation-free fields near the Thessaloniki (Greece), and information about soil moisture was obtained from own measurements using a thermogravimetric method. The second part drew data from the freely available ISMN database and the research was carried out on agricultural fields during the vegetation season in northwest Germany. The third part used soil moisture data from the Czech Hydrometeorological Institute (ČHMÚ) and the area of interest was two grassed areas of the airport and one agricultural field. Correlation was measured by calculating the determination coefficient and by using the linear regression an equation for calculating the soil moisture from the radar backscatter was compiled. High dependence has been confirmed when VV polarization with constant surface roughness were examined. In the case of surfaces with varying roughness and vegetation cover, only low correlation was found, similarly with using VH polarization. Key words: radar, SAR, Sentinel-1, soil...
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