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Detection of repetitive sequences in genomes
Puterová, Janka ; Jedlička, Pavel (referee) ; Kléma, Jiří (referee) ; Zendulka, Jaroslav (advisor)
Repetitivní sekvence mohou tvořit významnou část genomu, v některých případech více než 80%, která však bývala vědci často přehlížena. Dnes je známo, že repetice mají v genomu různé funkce a rozdělují se na dvě hlavní skupiny: rozptýlené a tandemové repetice. Cílem této práce bylo vytvoření bioinformatických nástrojů pro detekci repetic, ať už přímo ze sekvenačních dat generovaných sekvenátory, nebo ze sestavených genomů. V úvodní části práce poskytuje náhled do problematiky a přehled typů repetic vyskytujících se v genomech. Dále se práce zabývá stávajícími přístupy a nástroji zaměřenými na identifikaci repetic přímo ze sestavených sekvencí. Hlavním přínosem do této oblasti bylo vytvoření nástroje digIS, který se zaměřuje na detekci inserčních sekvencí, které přestavují nejhojněji se vyskytující rozptýlené repetice u prokaryot. digIS je založen na principu profilových skrytých Markovových modelů zkonstruovaných pro katalytické domény transpozáz, které představují nejkonzervativnější část inserčních sekvencí a zachovávají si sekundární strukturu v rámci rodiny. Následně práce poskytuje přehled sekvenačních technologií a rozebírá stávající metody pro detekci repetic přímo ze sekvenačních dat, bez nutnosti procházejícího sestavení genomu. Je představen nový přístup pro detailní analýzu tandemových repetic. Tento přístup rozšiřuje základní analýzu nástroje RepeatExplorer, který detekuje a charakterizuje repetice přímo ze sekvenačních dat. Práce dále diskutuje aplikace detekce repetic v biologickém výzkumu zejména z pohledu srovnávacích studií repeatomu a evoluce pohlavních chromozomů. V závěrečné části práce poskytuje souhrn dosažených výsledků výzkumu v podobě čtyř článků publikovaných v mezinárodních časopisech, jejichž plné znění je dostupné v přílohách, a celkové shrnutí práce a možnosti budoucího výzkumu.
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Information System Assessment and Proposal for ICT Modification
Dominik, Jan ; Fojtík, Jakub (referee) ; Koch, Miloš (advisor)
Information systems form an inseparable part of all business entities nowadays. They differ only in their size and complexity. Therefore each company should have its information system whose setting is adequate and maximally effective. The aim of this paper is to analyse the information system of NET4GAS, s.r.o., identify its weaknesses and propose changes to enhance it in order to increase the company efficiency.
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Evaluation design of civil airports effectivity indices
Novotný, Roman ; Janík, Radomír (referee) ; Veselý, Petr (advisor)
Introductory part of this thesis concludes the development of air traffic, division of airports in the Czech Republic according to the Ministry of Transport, according to the Law on Civil Aviation and according to the Coding of the airports (Requirement L 14). The aim was to realize theoretical definition and division of output and economic indicators. After that comes choice of appropriate airports from the European Union. The choice has been made on the basis of the number of check-in passengers at the airport in Prague-Ruzyně. Eight most suitable airports have been chosen from all twenty-seven member countries of the EU. The following step is comparative analysis of these chosen airports on the basis of specified output and economic indicators for the years 2005-2009. The year 2010 has not been included, because the chosen airports did not complete their annual reports, balances and statements of profit and loss. From these sources the values for calculation of individual indicators have been chosen. These indicators have been shown in charts, evaluated by means of graphs in Excel Programme and further they have been characterized in words. The aim of the thesis was also the evaluation and comparison of output and economic indicators of effectiveness and after evaluation, proposal of methods of evaluations has followed.
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Ekonomická úroveň krajín V4
Stejskalová, Charlotte
The bachelor thesis is devoted to comparing the economic level of the Visegrad Four countries using selected economic and socio-economic indicators. This thesis defines the economic level of the states based on the complex Human Development Index. In the statistical analysis of time series of the selected indicators, the reactions of individual states to changes in the external environment are compared. The events to which countries reacted to the greatest extent were the entry into the European Union, the economic crisis and the COVID-19 pandemic. Using regression analysis, countries are compared based on the size of the impact of economic and social aspects.
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The Decline of Terrorism in European soil: Comparative Political Analysis
Pinto Guzman, Isaac David ; Střítecký, Vít (advisor) ; Myftari, Kledian (referee)
1 Master Thesis : The Decline of Terrorism in European Soil: Comparative Political Analysis Written by Isaac David Pinto Guzmán Date: 31.07.2023 Charles University Department: Security Studies Supervisor: doc. PhDr. Vít Střítecký Student ID: 47544203 University of Konstanz Department: Politics and Public Administration Supervisor: Prof. Dr. Michael Dobbins Student ID: 1252046 2 Abstract: This paper focuses on the effectiveness of counterterrorism policies and strategies implemented by European Union (EU) member nations. The study examines the types of policies and measures put in place, the effectiveness of intelligence gathering and sharing, and the level of funding provided for security efforts. The research question guiding this study is: Which policies, security strategies, and measures implemented by European Union member nations have most effectively reduced the frequency or success rate of terrorist attacks on their territory, including completed, failed, and foiled attacks? The study aims to provide valuable insights for policymakers and security experts to develop evidence-based strategies to prevent and combat terrorism in the EU. The literature review critically examines the securitization of terrorism in Europe and its implications for civil liberties and democratic governance. The theoretical...
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Comparative analysis of climate change conference coverage in India and UK newspapers: framing difference
Devaraj, Yoheswari ; Miessler, Jan (advisor) ; Nečas, Vlastimil (referee)
Newspapers from India, a developing nation, and the UK, a developed one, are the focus of the investigation. These nations stand for a variety of social, political, and cultural situations that will undoubtedly have an impact on how the climate change conference is depicted. The thesis adds to an improved comprehension of the role played by the media in shaping climate change rhetoric and communications in various cultural and socioeconomic settings via this comparative examination. Considering the cultural differences between the two countries (developed vs. developing), there were similarities in the framing choices, which highlights the influence of the dominant global media narratives on how climate change is covered. It is acknowledged that this dominant position is essentially the result of fundamental historical inequalities that have led to an accumulation of political and economic power in the West. this was accomplished by examining five distinct frameworks to comprehend how they were used in the four newspapers' coverage of COP27.
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Comparison of the communication of the Czech government's anti-pandemic measures in the Czech Television and the daily Blesk
Dušková, Lucie ; Klabíková Rábová, Tereza (advisor) ; Miessler, Jan (referee)
This thesis analyses the communication of two major Czech media during the health crisis - the covid-19 pandemic. The thesis focuses on the first wave of the pandemic and through a comparative analysis examines the content of the public television broadcaster- Czech Television and the tabloid Blesk. The aim of the thesis is to find out how these two different media outlets presented key messages concerning anti-pandemic measures, and especially how they framed the messages. The theoretical part draws on the literature on media communication and briefly defines related concepts such as media function, construction of reality in the media, agenda setting and framing, then describes the differences between tabloid and news coverage and introduces the media studied. The thematic focus of the research follows the communication of the media in an unprecedented situation; therefore, the thesis further focuses on the role of the media in times of crisis, focusing on the extraordinary situation of the covid- 19 pandemic. The thesis then describes the research methodology in which I will present the methods used and the aim of the research. The methodology is followed by the analytical part, which is based on a content analysis of media messages related to anti-pandemic measures. The thesis then tries to...
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Comparison of the Czech and French Law of Succession and analysis of the relevant French Legal terminology with a glossary
ZÍKOVÁ, Tereza
The main aim of this bachelor thesis is a comparative analysis of the Czech and French legislation on inheritance law. The secondary objective is the analysis of the relevant legal terms. The thesis is divided into four main chapters, which are subsequently divided into subchapters. The first chapter deals with the Czech legal regulation of inheritance law. The second chapter deals with the regulation of inheritance law in France and the third chapter compares the Czech and French regulation of inheritance law. The last chapter contains an analysis of specific French legal terminology and includes a French-Czech glossary. The thesis ends with a conclusion and a summary in French.
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Financial Performance of State Owned Enterprises
FÁBEROVÁ, Anna
The aim of the diploma thesis is to present a comparative analysis of the financial performance of state-owned enterprises in the European Union aimed at finding the factors that affect this performance. First, the thesis deals with the definition of these enterprises, specifics and purport for society. For comparison, the thesis contains an overview of empirical studies that deal with the question of whether state-owned enterprises are efficient and effective. The financial performance of an enterprise is valued using traditional financial indicators such as: total indebtedness, liquidity, labour productivity, return on assets and investment rate. Comparative analysis and descriptive statistics will be used to find the factors that affect the performance of the enterprise. Then, the ANOVA test will be employed to verify whether there is a dependence of indicators on these factors.
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