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The Legacy of Antiquity, and Jewellery Historical and Contemporary(Glyptic Patterns; Ways of Rendering a Theme)
Matějovič, Petja ; Konečný, Lubomír (advisor) ; Cogan, Miroslav (referee) ; Nováková, Kateřina Nora (referee)
1 PhDr. Petra Matějovičová Thesis The Legacy of Antiquity, and Jewellery Historical and Contemporary (glyptic patterns; ways of rendering a theme) Abstract This thesis examines historical and contemporary jewellery, and specifically the ways in which jewellery bears meanings. To demonstrate these ways it uses formal patterns, motifs and themes in jewellery that are part of the legacy of antiquity. The thesis attempts to devise strategies for presenting jewellery's potential to an audience that has not previously been addressed by work of this kind, or has focused on a specific segment of jewellery. Inspiration from antiquity can be considered an attractive prism that is appropriate for the task in hand. The thesis avoids any categorising of jewellery according to the degree of its creators' input or any kind of ambitions (primarily it does not follow any definitions such as artist jewellery, studio jewellery, unique jewellery or conventional jewellery). It includes jewellery as a material object or objects and jewellery that does not possess this characteristic. The thesis considers and classifies jewellery according to a number of keys, although chronology is not one of them. Characteristics of Jewellery, an introductory chapter outlining as many factors as possible that are responsible for jewellery's...
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Blokáda sodíkového a přechodného draslíkového proudu perfenazinem: experimentální a simulační studie
Bébarová, M. ; Matejovič, P. ; Pásek, Michal ; Jansová, D. ; Šimurdová, M. ; Nováková, M. ; Šimurda, J.
The effect of a neuroleptic drug perphenazine on sodium current INa and transient outward potassium current Ito was studied in rat ventricular myocytes at room temperature. Perphenazine reversibly blocked INa (reducing its amplitude; IC50 = 1.24 +/- 0.10 μmol/l, nH =0.99 +/- 0.08) and Ito (accelerating its apparent inactivation with a slight decrease of its amplitude; IC50 = 38.2 +/- 3.5 μmol/l, nH = 0.75 +/- 0.07, evaluated from the changes of time integral). Both INa- and Ito-block was use- and frequency-dependent (20%-increase of INablock and 10%-increase of Ito-block under 0.3 and 10 μmol/l perphenazine, respectively, at the stimulation frequency of 3.3 Hz applied after a 15-s rest). The results of quantitative modelling suggest that perphenazine interacts with INa-channels in inactivated states, and with Ito-channels in both open and open-inactivated states.
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Účinek perphenazinu na přechodný draslíkový proud u komorových buněk potkana
Bébarová, M. ; Matejovič, P. ; Pásek, Michal ; Račkauskas, G. ; Šimurdová, M. ; Šimurda, J. ; Nováková, M.
The aim of this study was to explore the effect of a phenothiazine neuroleptic drug perphenazine on transient outward potassium current Ito in rat ventricular myocytes. Perphenazine reversibly decreased the amplitude and accelerated the apparent inactivation of Ito in a concentration-dependent manner with EC50 = 26.4 +/- 3.5 µmol/l and Hill coefficient n = 0.84 +/- 0.10 (evaluated from changes of time integral of Ito). Time course of Ito-inactivation was well fitted by a double exponential function; the fast time constant was significantly decreased under the effect of perphenazine and its concentration dependence was comparable with the concentration dependence of Ito-block represented by time integrals (EC50 = 26.8 +/- 8.2 µmol/l, n = 0.88 +/- 0.28). It is suggested that perphenazine-induced block via open channel is very likely involved in the mechanism of drug-channel interaction.
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