Original title: Voltage clamp analysis of ajmaline-induced block of potassium currents in ventricular myocytes
Authors: Bahníková, M. ; Matějovič, P. ; Pásek, Michal ; Šimurdová, M. ; Šimurda, J.
Document type: Papers
Conference/Event: Biosignal 2002, Brno (CZ), 2002-06-26 / 2002-06-28
Year: 2002
Language: eng
Abstract: This study was aimed to analyze the effects of the antiarrhythmic drug ajmaline (a known inhibitor of the fast sodium current INa) on the potassium currents, namely the transient outward current (Ito) and the current measured at the end of a depolarizing pulse (IK) in rat ventricular myocytes. Both currents were inhibited in concentration- and voltage-dependent manner. However, the effects were frequency-independent.
Keywords: ajmaline; cardiac cell; potassium currents
Project no.: CEZ:AV0Z2076919 (CEP)
Host item entry: Analysis of biomedical signals and images, ISBN 80-214-2633-0, ISSN 1211-412X

Institution: Institute of Thermomechanics AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0107741

Permalink: http://www.nusl.cz/ntk/nusl-31447


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Research > Institutes ASCR > Institute of Thermomechanics
Conference materials > Papers