Original title: Voltage and frequency dependent block of sodium current in cardiac cells. Comparison of the effect of two antiarrhythmic drugs
Authors: Matějovič, P. ; Bahníková, M. ; Pásek, Michal ; Šimurdová, M. ; Šimurda, J.
Document type: Papers
Conference/Event: Biosignal 2002, Brno (CZ), 2002-06-26 / 2002-06-28
Year: 2002
Language: eng
Abstract: Ionic currents recorded in voltage clamp experiments on enzymatically isolated rat ventricular myocytes were analyzed with the aim to study the voltage and frequency dependence of sodium current block induced by two antiarrhythmic drugs: ajmaline and propafenone. The levels of block produced by both examined agents were clearly related to membrane voltage. Interestingly, ajmaline, in contrast to propafenone, did not show frequency and use dependent effect. These differences are analyzed.
Keywords: antiarrhythmic drugs; cardiac cell; sodium current
Project no.: CEZ:AV0Z2076919 (CEP)
Host item entry: Analysis of biomedical signals and images, ISBN 80-214-2633-0, ISSN 1211-412X

Institution: Institute of Thermomechanics AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0107742

Permalink: http://www.nusl.cz/ntk/nusl-31448


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Research > Institutes ASCR > Institute of Thermomechanics
Conference materials > Papers