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Selekce potravy bobrem evropským (Castor fiber) ve čtyřech ročních obdobích
Macháčková, Kateřina
This thesis deals with the evaluation of Eurasian beaver foraging in cultural landscapes. The theoretical part is devoted to the existing knowledge concerning the selection of food by beavers and the factors influencing it. In the practical part, a total of nine stomachs of hunted or dead beaver individuals from different seasons are evaluated by means of the volumetric method. The results indicate that the ratios of the major constituents change during the seasons. As expected, the woody component is represented in the winter months, while its composition varies during the growing season. In summer, among other things, the representation of field crops is interesting. In spring and autumn there are transitions between woody and green biomass.
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Analogues of IGF-1 for the study of interactions of the hormone with the receptors for IGF-1 and insulin
Macháčková, Kateřina ; Jiráček, Jiří (advisor) ; Obšilová, Veronika (referee) ; Šulc, Miroslav (referee)
Insulin/IGF system is a complex network of three similar hormones (insulin, IGF-1 and IGF-2) and their three similar receptors (IR-A, IR-B and IGF-1R,), which play important roles in maintaining basal energy homeostasis of the organism, in growth, development, life-span but also in development of diseases such as diabetes mellitus, cancer, acromegaly or Laron dwarfism. Despite structural similarities between family members, each member have its unique role in the system. Identification of structural determinants in insulin and IGFs that trigger their specific signalling pathways is important for rational drug design for safer treatment of diabetes or for more efficient combating of cancer or growth-related disorders. In this thesis, we focused on identification of such structural determinants in IGF-1. Comparison of our data with parallel studies with IGF-2 and insulin could give a more complex picture of the problem. First of all, we developed necessary methodologies for the preparation of IGF-1 analogues. We developed a new methodology for the total chemical synthesis of IGF-1 analogues based on the solid-phase synthesis of fragments and their ligation by a CuI -catalyzed cycloaddition of azides and alkynes. In parallel, we developed a procedure for a recombinant production of IGF- 1 and its...
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Specificity of education social disadvantaged child
Macháčková, Kateřina ; Hájková, Vanda (advisor) ; Felcmanová, Lenka (referee)
TITLE: Specificity of education social disadvantaged child SUMMARY: This thesis deals with familiarity and experience of teachers and the principal of special education stream with the integration of socially disadvantaged pupils. The work deals with the reputation of so-called "Common Education" in the professional community of teachers, special education teachers and other educational staff. It also deals with experienced teachers with the integration of these pupils. It also dedicates level of awareness about who is a disciple of underprivileged knowledge and methods that can help this integration. Finally, the work deals with the familiarity of an amendment to the Education Act no. 82/2015 and knowledge of individual impacts on working with the student. Furthermore, the work deals with the degree of acceptance of compulsory attendance in the final year of nursery school and the abolition of preparatory classes. Also, the work deals with the possibilities that offers teachers plan educational support. KEYWORDS: Common education, amendment 82/2015, inclusion, special education, social disadvantage, socially disadvantaged pupils, plan educational assistance, canceling preparatory classes.
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Analogues of IGF-1 for the study of interactions of the hormone with the receptors for IGF-1 and insulin
Macháčková, Kateřina
Insulin/IGF system is a complex network of three similar hormones (insulin, IGF-1 and IGF-2) and their three similar receptors (IR-A, IR-B and IGF-1R,), which play important roles in maintaining basal energy homeostasis of the organism, in growth, development, life-span but also in development of diseases such as diabetes mellitus, cancer, acromegaly or Laron dwarfism. Despite structural similarities between family members, each member have its unique role in the system. Identification of structural determinants in insulin and IGFs that trigger their specific signalling pathways is important for rational drug design for safer treatment of diabetes or for more efficient combating of cancer or growth-related disorders. In this thesis, we focused on identification of such structural determinants in IGF-1. Comparison of our data with parallel studies with IGF-2 and insulin could give a more complex picture of the problem. First of all, we developed necessary methodologies for the preparation of IGF-1 analogues. We developed a new methodology for the total chemical synthesis of IGF-1 analogues based on the solid-phase synthesis of fragments and their ligation by a CuI -catalyzed cycloaddition of azides and alkynes. In parallel, we developed a procedure for a recombinant production of IGF- 1 and its...
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Analogues of IGF-1 for the study of interactions of the hormone with the receptors for IGF-1 and insulin
Macháčková, Kateřina
Insulin/IGF system is a complex network of three similar hormones (insulin, IGF-1 and IGF-2) and their three similar receptors (IR-A, IR-B and IGF-1R,), which play important roles in maintaining basal energy homeostasis of the organism, in growth, development, life-span but also in development of diseases such as diabetes mellitus, cancer, acromegaly or Laron dwarfism. Despite structural similarities between family members, each member have its unique role in the system. Identification of structural determinants in insulin and IGFs that trigger their specific signalling pathways is important for rational drug design for safer treatment of diabetes or for more efficient combating of cancer or growth-related disorders. In this thesis, we focused on identification of such structural determinants in IGF-1. Comparison of our data with parallel studies with IGF-2 and insulin could give a more complex picture of the problem. First of all, we developed necessary methodologies for the preparation of IGF-1 analogues. We developed a new methodology for the total chemical synthesis of IGF-1 analogues based on the solid-phase synthesis of fragments and their ligation by a CuI -catalyzed cycloaddition of azides and alkynes. In parallel, we developed a procedure for a recombinant production of IGF- 1 and its...
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Analogues of IGF-1 for the study of interactions of the hormone with the receptors for IGF-1 and insulin
Macháčková, Kateřina ; Jiráček, Jiří (advisor) ; Obšilová, Veronika (referee) ; Šulc, Miroslav (referee)
Insulin/IGF system is a complex network of three similar hormones (insulin, IGF-1 and IGF-2) and their three similar receptors (IR-A, IR-B and IGF-1R,), which play important roles in maintaining basal energy homeostasis of the organism, in growth, development, life-span but also in development of diseases such as diabetes mellitus, cancer, acromegaly or Laron dwarfism. Despite structural similarities between family members, each member have its unique role in the system. Identification of structural determinants in insulin and IGFs that trigger their specific signalling pathways is important for rational drug design for safer treatment of diabetes or for more efficient combating of cancer or growth-related disorders. In this thesis, we focused on identification of such structural determinants in IGF-1. Comparison of our data with parallel studies with IGF-2 and insulin could give a more complex picture of the problem. First of all, we developed necessary methodologies for the preparation of IGF-1 analogues. We developed a new methodology for the total chemical synthesis of IGF-1 analogues based on the solid-phase synthesis of fragments and their ligation by a CuI -catalyzed cycloaddition of azides and alkynes. In parallel, we developed a procedure for a recombinant production of IGF- 1 and its...
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Specificity of education social disadvantaged child
Macháčková, Kateřina ; Hájková, Vanda (advisor) ; Felcmanová, Lenka (referee)
TITLE: Specificity of education social disadvantaged child SUMMARY: This thesis deals with familiarity and experience of teachers and the principal of special education stream with the integration of socially disadvantaged pupils. The work deals with the reputation of so-called "Common Education" in the professional community of teachers, special education teachers and other educational staff. It also deals with experienced teachers with the integration of these pupils. It also dedicates level of awareness about who is a disciple of underprivileged knowledge and methods that can help this integration. Finally, the work deals with the familiarity of an amendment to the Education Act no. 82/2015 and knowledge of individual impacts on working with the student. Furthermore, the work deals with the degree of acceptance of compulsory attendance in the final year of nursery school and the abolition of preparatory classes. Also, the work deals with the possibilities that offers teachers plan educational support. KEYWORDS: Common education, amendment 82/2015, inclusion, special education, social disadvantage, socially disadvantaged pupils, plan educational assistance, canceling preparatory classes.
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Methodology of snowboarding - Digital processing
Macháčková, Kateřina ; Turčová, Ivana (referee) ; Gnad, Tomáš (advisor)
Title of work: Methodology of snowboarding - Digital processing Object of thesis: The point of this thesis is to make a model of DVD presentation, which should present complete methodical series that could be used for teaching sport called snowboarding. Methods: Analyse of printed or non-printed (electronic) documents. Production of texts for DVD presentation Production of video records. Creation of scenarios Selection of camcoder Editing video records Option of terrain Production of model DVD presentation. Creation of program interface Creation of computer graphics Results: Snowboarding is sport with huge complex of skills which we need to train continuously with constant repeating alias these skills are good to practice. The DVD can be used by beginners as an introduction to snowboarding, or the more advanced snowboarders for making their techniques more perfect or to enlarge their knowledge of this nice sport. Key words: Snowboarding, methodology 3
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