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Perspectives on the use of metabolic engineering in beta-lactam antibiotic biosyntheses
Pitkina, Anastasiya ; Kyslík, Pavel (advisor) ; Nunvář, Jaroslav (referee)
At present beta-lactams achieve leading positions among antibiotics as to the volume of sales and importance of utilization. This thesis compares selected industrially used chemical and enzymatic ways of production of beta-lactam antibiotics and further concentrates on the application of relatively novel approach of metabolic engineering in beta-lactam biosyntheses. Currently some of the described methods based on metabolic engineering are already being applied in production processes,whereas other technologies remain rather a theoretical possibility.
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Transfer of technology for production of AEH from Sphingomonas sp
Kyslíková, Eva ; Palyzová, Andrea ; Marešová, Helena ; Štěpánek, Václav ; Zahradník, Jiří ; Bečka, Stanislav ; Dobišová, Marie ; Kyslík, Pavel
Research report on construction of a recombinant production microorganism, the way of its cultivation in stirred bioreactor, overproduction and isolation of AEH and stabilization of AEH as cross linked enzyme agregate
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