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A New Hollow Fiber-Based Liquid-Phase Microextraction Method for the Determination of Antihypertensive Drug Lercanidipine in Biological Samples
Labzova, O. ; Hrdlička, Vojtěch ; Navrátil, Tomáš ; Šelešovská, R.
A new hollow fiber-based liquid-phase microextraction (HF-LPME) method for the determination of antihypertensive drug lercandipine (LCN) in biological samples was developed. HF-LPME was\ncombined with optimized square wave voltammetry (SWV) on a cathodically pre-treated screenprinted boron-doped diamond electrode (SP-BDDE). Optimum HF-LPME conditions were:\nsupported liquid membrane (SLM) dodecane, 0.02 mol L-1 Britton-Robinson buffer (BRB, pH = 3) acceptor phase, BRB (pH = 7) donor phase, and time of extraction 30 min. Limits of quantification (LOQ) and detection (LOD) were 3.3 and 1.1 nmol L-1, respectively. The applicability of the developed method was verified on human urine, blood serum, and blood plasma with 20 and 100 nmol L-1 LCN addition.
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A New Approach to Determining the Drug Guaifenesin Using Voltammetric and Flow Injection Analysis
Kelíšková, P. ; Matvieiev, O. ; Sokolová, Romana ; Janíková, L. ; Behúl, M. ; Šelešovská, R.
This study presents a new method for detecting guaifenesin (GFE) in pharmaceutical samples. We employed screen-printed sensors with a boron-doped diamond electrode (BDDE) to develop and validate both voltammetric and flow amperometric methods. These approaches were effectively used to analyze model solutions, pharmaceutical preparations, and serum samples spiked with GFE, producing accurate results comparable to those obtained with HPLC/DAD analysis. The developed methods provide straightforward, sensitive, and selective means for determining GFE in various sample matrices, underscoring the potential of SP/BDDE in electrochemical analysis.
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Segmentation of Hippocampus in MRI Data
Kodym, O.
This project deals with application of graph-based methods in segmentation of low contrast image data, specifically hippocampus in MRI data. Using graph cuts for the segmentation allows the software to utilize high accuracy, robustness and an ability to interact with the user.
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Instruments for precipitation measurement from history to the present
Lipina, P. ; Procházka, J. ; Tesař, Miroslav
The precipitation amount is one of the most important meteorological elements. It is of fundamental importance for the creation of climatological characteristics, it is the basis of the water balance and the primarily monitored element in the forecasting and warning service. Precipitation measurement has been burdened with many uncertainties for a long time and is therefore consistently given due attention.\nThe first measurement of precipitation in Europe dates back to the 17th century. Regular but not complete measurements of precipitation at Prague's Klementine observatory began in 1752 (continuous series since 1804), in Brno in 1803. In 1817, M.A. David wrote the first guide for observing the weather in Bohemia, published in German, intended for volunteer observers. The activities of institutions and various associations, such as the Prague Klementinum, the Natural Research Society in Brno, the Central Institute for Meteorology and Earth Magnetism and others, had a fundamental influence on the establishment of meteorological stations and precipitation measurements. The Hydrographic Commission for the Kingdom of the Czech Republic and its hydrometric section were founded in 1875 under the leadership of F. J. Studnička E. Purkyně was responsible for the significant expansion of precipitation measurement at that time as part of the construction of a network of forest precipitation measuring stations. \nFor more than 200 years, rain gauges and precipitation measurements have been developed. The Metra 886 manual rain gauge, which has been used for a long time in the Czech lands, was developed according to the Austrian model of prof. Kostlivý. Since 1995, the automation of rainfall measurement was started, first with tipping bucket raingauges, which are gradually being replaced by weighing raingauges. Alternative methods of measuring precipitation are being tested in\nremote and forested areas. This post tries to bring the history, standards and development of precipitation measurement in our country at least as a guide.
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Temperature regime of forest soils
Dohnal, M. ; Votrubová, J. ; Mazúchová, R. ; Blunár, P. ; Tesař, Miroslav
Contribution deals with the monitoring of the temperature regime of forest soils and the soil heat flux at small mountainous basins Liz in the Šumava Mts. and Uhlířská in the Jizera Mts. Soil temperatures are measured with the help of soil moisture meters (Pt100 at Liz basin and CS107 at Uhlířská basin), the soil heat flux is measured with the use of the sensor Hukseflux HFP01. Measured results were statistically evaluated, the analysis of the consistence of the measurement was done and cumulative soil heat fluxes were calculated for the individual hydrological years.
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Palingenesis - the restoration of everything? (Matthew 19,28)
Dus, Jan A
In Matthew’s version of Jesus’ promise (Matthew 19:28–30), in contrast to Mark and Luke, there is no explicit mention of the present time, the restitution of all that the followers of Jesus left behind is thus pushed forward to the future, in which they will take over the reigns with the Son of Man. The promise features the rare term “palingenesis”, whose precise temporal and factual determination cannot be deduced from the sentence itself. While in Mt 19:28 palingenesis is, according to the prevailing interpretation, a synonym for the future restoration of the universe, in Tit 3:5 (the only other occurrence in the NT) the same word refers to the rebirth of some people that took place in the past (at baptism). Even non-biblical literature does not provide a clear precedent - palingenesis tends to be set both in the past and in the future, it concerns both the world and individuals or groups (Israel). – The syntax and punctuation of the Greek sentence show that both interpretations are equally possible: palingenesis can be related either (A) to the following verbal form “sitting (the Son of Man on the throne)”, i.e. to the future, or (B) to the preceding verbal form “following (disciples behind Jesus)”, i.e. into the past, in addition, there is a third, open option (C). In the 16th-century Greek, Latin, and Czech versions, all possibilities are represented: Erasmus punctuates the Vulgate differently (B), Beza first respects the Vulgate (A), but in his Annotations he considers the second solution (B), in the fourth and fifth editions he finally leaves the matter open (C), two Czech translations from the first half of the 16th century (Náměšť 1533, Melantrich 1556/57) hesitate in the dilemma between the Vulgate and Erasmus (C), most Brethren translations starting with Blahoslav (1564) deviate from the Vulgate (B), only the Six-Volume Kralice Bible from 1593/94 (“Kralická Šestidílka”) hesitates (C), in “Kralická Šestidílka” and in the Kralice New Testament from 1601 the Brethren pay equal attention to both interpretations in a rather extensive note, which, for its balance, is a nice proof of intellectual openness and tolerance. Like Beza, the Brethren add a new aspect to interpretation (B): palingenesis can mean the renewal of the whole world thanks to the Gospel and the first coming of the Messiah. – Considering the dynamic development in the 16th century, it is surprising that all ten tracked Czech translations from around the 20th century agree on only one variant (A). Option (B) seems to be in danger of unfair oblivion. Therefore, in conclusion, we allow ourselves to propose a new, somewhat looser translation or paraphrase of verse Mt 19:28 in the spirit of Kralice: “Amen, I say to you, it was you who followed me when I came to renew the world with the gospel, and when the Son of Man sits on the throne of his glory, it will be you again who will sit on twelve thrones and judge the twelve tribes of Israel.”
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Inverse-Heusler Mn2FeSi alloy prepared by powder metallurgy route
Životský, O. ; Skotnicová, K. ; Čegan, T. ; Juřica, J. ; Gembalová, L. ; Zažímal, František ; Jirásková, Yvonna ; Szurman, I.
The Mn2FeSi inverse-Heusler alloy was prepared by solid-state reactions using ball milling for 168 h in n hexane. Two milling procedures varying in the ball-to-powder ratio, namely 4:1 and 10:1, were used to follow \ntheir influence on alloy formation and its physical properties. In both cases no Heusler structure was obtained \ndirectly and therefore the subsequent annealing at 1223 K for 1.5 h in pure Ar was applied. The energy dispersive X-ray analysis resulted in the chemical composition about 49.0-49.9 at% Mn, 25.3-25.6 at% Fe, and \n24.8-25.4 at% Si, in a good agreement with nominal one. X-ray diffraction of both powders confirmed inverse Heusler XA structure of lattice parameters 0.5675 nm (4:1) and 0.5677 nm (10:1), only slightly higher as \ntheoretically obtained 0.560 nm. The presence of minor oxidation phases was also observed in the particle \nstructure of powders. Magnetic properties were analysed at low and room temperatures. Both alloys exhibit \nparamagnetic behaviour at room temperature confirmed by transmission Mössbauer spectroscopy \nmeasurements. Different magnetic behaviour of alloys is observed below 65 K.
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Kosher in lexicography. Problems of one religion term
Dvořáková, Žaneta
The Hebrew term košer (‘kosher’) came into Czech through Jewish sociolect / ethnolect. It was originally a religious term for what is ritually pure and appropriate. In addition to the adjective and adverb košer, Czech dictionaries also contain a number of other forms and derivatives, but some of them are no longer used at the moment (e.g. košerný, košerně). Our evaluation is based on an analysis of material base from the Syn2015 Corpus and from a probe into contemporary texts in Jewish magazines or on the websites of Jewish communities and organizations. In Czech dictionaries, we may see a reduction of the meaning compared to how the term is traditionally used in the Jewish community, e.g. the adjective košer is limited to meat, the verb košerovat is associated only with the ritual slaughter. The nouns mentioned in the dictionaries are also very debatable: masculine košer in the sense of ‘butcher’ and masculine košer with the meanings of ‘cut’ and ‘food appropriate for Jews to eat’, these are based on isolated documents from the works of authors apparently unfamiliar with the Jewish community. The question then is whether (and according to what criteria) such words should be included in the dictionaries.
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Digital twin skin of the drinking water treatment plant - development and use in practice
Sochorová, Helena ; Andreides, D. ; Hložanka, F. ; Prokopová, Michaela ; Stejskal, O. ; Chalupa, L. ; Šmejkalová, P. ; Dolejš, P.
The contribution presents experiences with the development of a digital twin for optimizing the control of the DWTP within the pilot project in the Železná Ruda locality. The digital twin consists of two components, i.e. digital documentation in the object architecture processed by the reverse engineering process, which is data-connected with the real physical infrastructure (virtual replica of the infrastructure) and a simulation tool based on a mathematical model or a neural network (simulation of the water treatment process). Both components are accessible to the user via a web application, in which one can choose from three operating states (monitoring of the real state - default, simulation of scenarios of operating settings and prediction of pressure loss).
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Tombstones of the Švamberks of the 15th – early 17th Century from an Art Historical Perspective
Chlíbec, Jan
Only a fragment has remained from the original collection of the Švamberk family tombstones that was still quite large at the beginning of the 18th century. Surprisingly,\neven though the Švamberks were a prominent noble family, the surviving works usually show average or below-average quality which, as far as the 15th century works are concerned, reflect the prevailing condition of sepulchral sculpture in Bohemia of the time. More factors could have been behind opting for an austere form of the tombstone. In addition to the Utraquist criticism of majestic funeral works and the lack of high-quality stonemasons after the Hussite Wars, it could be the general idea of resistance to pride and accentuation of the confirmation of Christian modesty regardless of the buried person’s confession.\n
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