Original title: A New Hollow Fiber-Based Liquid-Phase Microextraction Method for the Determination of Antihypertensive Drug Lercanidipine in Biological Samples
Authors: Labzova, O. ; Hrdlička, Vojtěch ; Navrátil, Tomáš ; Šelešovská, R.
Document type: Papers
Conference/Event: Modern Electrochemical Methods /43./, Jetřichovice (CZ), 20240520
Year: 2024
Language: eng
Abstract: A new hollow fiber-based liquid-phase microextraction (HF-LPME) method for the determination of antihypertensive drug lercandipine (LCN) in biological samples was developed. HF-LPME was\ncombined with optimized square wave voltammetry (SWV) on a cathodically pre-treated screenprinted boron-doped diamond electrode (SP-BDDE). Optimum HF-LPME conditions were:\nsupported liquid membrane (SLM) dodecane, 0.02 mol L-1 Britton-Robinson buffer (BRB, pH = 3) acceptor phase, BRB (pH = 7) donor phase, and time of extraction 30 min. Limits of quantification (LOQ) and detection (LOD) were 3.3 and 1.1 nmol L-1, respectively. The applicability of the developed method was verified on human urine, blood serum, and blood plasma with 20 and 100 nmol L-1 LCN addition.
Keywords: Hollow fiber liquid-phase microextraction; Lercanidipine hydrochloride; Screenprinted boron-doped diamond electrode
Host item entry: Proceedings of the International Conference. 43rd Modern Electrochemical Methods, ISBN 978-80-908947-1-6

Institution: J. Heyrovsky Institute of Physical Chemistry AS ČR (web)
Document availability information: Fulltext is available on demand via the digital repository of the Academy of Sciences.
Original record: https://hdl.handle.net/11104/0353835

Permalink: http://www.nusl.cz/ntk/nusl-615867


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Research > Institutes ASCR > J. Heyrovsky Institute of Physical Chemistry
Conference materials > Papers