Název: Design and synthesis of specific colevelin derivatives for in vitro and in vivo studies
Autoři: Kostomoiri, M. ; Zikos, C. ; Benaki, D. ; Slaninová, Jiřina ; Pirmettis, I. ; Papadopoulos, M. ; Pelecanou, M. ; Livaniou, E.
Typ dokumentu: Příspěvky z konference
Konference/Akce: Biologically Active Peptides /12./, Praha (CZ), 2011-04-27 / 2011-04-29
Rok: 2011
Jazyk: eng
Abstrakt: Colivelin is the most potent member of the humanin family of neuroprotective peptides with in vitro and in vivo action against insults associated with Alzeimer’s Disease. The mechanism of action of colivelin is not yet elucidated. The objective of the present study is the design and synthesis of specific colivelin derivatives that can be used as molecular probes in in vitro and in vivo biological experiments. In the frame of the study three colivelin derivatives bearing suitable tags, i.e the fluorescent moiety FITC, the 99mTc-radiometal chelating unit dimethylGly-Ser-Cys, and the streptavidin-counterpart biotinyl-group, were designed and synthesized. These derivatives will be used in in vitro cell component binding and in vivo biodistribution experiments, in order to gain better insight on the mode of the neuroprotective action of colivelin.
Klíčová slova: Alzheimer's disease; colivelin; humanin; neuroprotective peptides
Číslo projektu: CEZ:AV0Z40550506 (CEP)
Zdrojový dokument: Biologically Active Peptides. 12th Conference, ISBN 978-80-86241-44-9

Instituce: Ústav organické chemie a biochemie AV ČR (web)
Informace o dostupnosti dokumentu: Dokument je dostupný v příslušném ústavu Akademie věd ČR.
Původní záznam: http://hdl.handle.net/11104/0204339

Trvalý odkaz NUŠL: http://www.nusl.cz/ntk/nusl-81014


Záznam je zařazen do těchto sbírek:
Věda a výzkum > AV ČR > Ústav organické chemie a biochemie
Konferenční materiály > Příspěvky z konference