Název:
In vitro and in vivo antimicrobial effect of lasioglossins on the Candida albicans
Autoři:
Kašperová, A. ; Turánek, J. ; Čeřovský, Václav ; Raška, M. Typ dokumentu: Příspěvky z konference Konference/Akce: Biologically Active Peptides /12./, Praha (CZ), 2011-04-27 / 2011-04-29
Rok:
2011
Jazyk:
eng
Abstrakt: Lasioglossins represent a new group of amphipathic α-helical peptides with significant antimicrobial effect on the Candida albicans. This study examines the antifungal activity of two peptides LL-III and all D-LL-III as measured by the suppression of Candida proliferation and suppression of induced morphological differentiation both in in vitro and in vivo assays. In the in vitro Candida proliferation assay, the inhibitory effect of lasioglossins LL-III and all D-LL-III was more than 70% within 24 h and more than 84% after 48 h of incubation (final concentration of either peptide was 17.5 .mu.M). Delaying of blastoconidial transition to hyphae in vitro and tendency to suppress vaginal candidiasis in experimental mice were detected.
Klíčová slova:
antimicrobial activity; Candida viability; flow cytometry analysis; vaginal candidiasis Číslo projektu: CEZ:AV0Z40550506 (CEP), GA203/08/0536 (CEP) Poskytovatel projektu: GA ČR Zdrojový dokument: Biologically Active Peptides. 12th Conference, ISBN 978-80-86241-44-9
Instituce: Ústav organické chemie a biochemie AV ČR
(web)
Informace o dostupnosti dokumentu:
Dokument je dostupný v příslušném ústavu Akademie věd ČR. Původní záznam: http://hdl.handle.net/11104/0204338