Original title: Fmoc deprotection by tert-butylamine and its comparison in solution and solid phase synthesis
Authors: Flegel, Martin ; Flegelová, Z. ; Maloň, Petr ; Klenerová, V. ; Hynie, S.
Document type: Papers
Conference/Event: Biologically Active Peptides /12./, Praha (CZ), 2011-04-27 / 2011-04-29
Year: 2011
Language: eng
Abstract: tert-Butylamine was employed as the alternative to piperidine for Fmoc deprotection in liquid and solid phase peptide synthesis. Basic kinetic parameters of deprotecting reaction were checked in chosen Fmoc amino acid derivatives. Solid phase synthesis of cyclic part of oxytocin (tocinamide) was worked out and used for CD spectra measurement.
Keywords: CD spectra; Fmoc deprotection; oxytocin cycle; tert-Butylamine (TBA)
Project no.: CEZ:AV0Z40550506 (CEP), KAN200520703 (CEP), KAN200100801 (CEP)
Funding provider: GA AV ČR, GA AV ČR
Host item entry: Biologically Active Peptides. 12th Conference, ISBN 978-80-86241-44-9

Institution: Institute of Organic Chemistry and Biochemistry AS ČR (web)
Document availability information: Fulltext is available at the institute of the Academy of Sciences.
Original record: http://hdl.handle.net/11104/0204314

Permalink: http://www.nusl.cz/ntk/nusl-81010


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Research > Institutes ASCR > Institute of Organic Chemistry and Biochemistry
Conference materials > Papers