Název:
Lucifensin, a peptide behind the maggot therapy
Autoři:
Čeřovský, Václav Typ dokumentu: Příspěvky z konference Konference/Akce: Biologically Active Peptides /12./, Praha (CZ), 2011-04-27 / 2011-04-29
Rok:
2011
Jazyk:
eng
Abstrakt: The larvae of the green bottle fly (Lucilia sericata) are routinely used as a medication for the treatment of necrotic, non-healing and highly infected wound in many hospitals all over the world. We have identified and determined primary structure of the defensin originated from the immune system of Lucilia sericata larvae and named it lucifensin. This is 40 amino acid residues and three intramolecular disulfide bridges peptide. The synthetic lucifensin was active against Gram-positive bacteria and was not hemolytic. We studied the importance of lucifensin disulfide bridges and the N-terminal part of its molecule for the structure and for antimicrobial activity.
Klíčová slova:
antimicrobial activity; disulfide bridge; lucifensin; maggot therapy; peptide synthesis Číslo projektu: CEZ:AV0Z40550506 (CEP), GA203/08/0536 (CEP) Poskytovatel projektu: GA ČR Zdrojový dokument: Biologically Active Peptides. 12th Conference, ISBN 978-80-86241-44-9
Instituce: Ústav organické chemie a biochemie AV ČR
(web)
Informace o dostupnosti dokumentu:
Dokument je dostupný v příslušném ústavu Akademie věd ČR. Původní záznam: http://hdl.handle.net/11104/0204306